HitPredict

Interactor 1: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Interactor 2: VSX1 (Q9NZR4)
Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1)
Gene: VSX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35140242
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1291 Hs			1 365
+	Hs
		1065721 SETB1_HUMAN (1-1291): 0: 1373: 100.00		LHX5_HUMAN (104-365): 5.06e-30: 120: 19.79
+	Hs
		1334136 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		VSX1_HUMAN (1-365): 4.39e-58: 194: 100.00
+	Hs
		1296426 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		VSX1_HUMAN (1-365): 4.39e-58: 194: 100.00
+	Hs
		839827 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		LHX2_HUMAN (78-301): 8.5e-35: 133: 24.11
+	Hs
		641566 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		PAX6_HUMAN (116-362): 8.15e-30: 120: 24.22
+	Hs
		822681 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		LHX1_HUMAN (101-362): 3.26e-29: 118: 17.61
+	Hs
		839806 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		LHX2_HUMAN (78-301): 8.5e-35: 133: 24.11
+	Mm
		453079 EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11		HXA9_MOUSE (73-230): 1.68e-31: 121: 28.75
+	Hs
		641528 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		PAX6_HUMAN (116-362): 8.15e-30: 120: 24.22
+	Hs
		822665 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		LHX1_HUMAN (101-362): 3.26e-29: 118: 17.61
+	Hs
		839785 KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27		LHX2_HUMAN (78-301): 8.5e-35: 133: 24.11
+	Hs
		882142 KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27		GSC_HUMAN (1-261): 4.39e-33: 125: 26.05
+	Hs
		620175 KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27		PAX7_HUMAN (147-358): 9.14e-30: 121: 26.99
+	Hs
		641482 KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27		PAX6_HUMAN (116-362): 8.15e-30: 120: 24.22
+	Hs
		822650 KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27		LHX1_HUMAN (101-362): 3.26e-29: 118: 17.61
+	Hs
		873091 EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13		PRRX1_HUMAN (115-249): 3.59e-36: 133: 33.10
+	Hs
		1300555 SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00		ARX_HUMAN (159-224): 1.47e-18: 89: 69.70