Protein: DEN4C
DENN domain-containing protein 4C

Gene: DEN4C, DENND4C
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q5VZ89

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

976328

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

729930

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.735

High

966451

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

990339

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

1049403

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

971631

1433E
14-3-3 protein epsilon

4

5

High-throughput

0.694

High

691112

1433T
14-3-3 protein theta

4

20

High-throughput

0.690

High

126646

RHOD
Rho-related GTP-binding protein RhoD

1

18

High-throughput

0.618

High

630837

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.618

High

631278

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.618

High

901302

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.618

High

901867

RAB9A
Ras-related protein Rab-9A

1

19

High-throughput

0.618

High

956338

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.618

High

988436

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.618

High

1144954

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.618

High

1219594

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.618

High

1219603

DEN1A
DENN domain-containing protein 1A

1

5

High-throughput

0.618

High

1219621

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.618

High

1219642

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.618

High

540494

LAMP1
Lysosome-associated membrane glycoprotein 1

2

6

High-throughput

0.584

High

1219637

FBW1B
F-box/WD repeat-containing protein 11

2

4

High-throughput

0.584

High

290033

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

930929

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.536

High

1219598

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1219610

VPS35
Vacuolar protein sorting-associated protein 35

1

1

High-throughput

0.536

High

642563

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1219618

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1219626

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.513

High

881541

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.489

High

122507

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

2

High-throughput

0.479

High

172926

XPO1
Exportin-1

1

5

High-throughput

0.479

High

176837

DCLK1
Serine/threonine-protein kinase DCLK1

1

3

High-throughput

0.479

High

189626

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

208679

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

3

High-throughput

0.479

High

218305

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

226068

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

230538

KIF1C
Kinesin-like protein KIF1C

1

6

High-throughput

0.479

High

252080

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

269562

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.479

High

281337

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.479

High

339083

NADK
NAD kinase

1

1

High-throughput

0.479

High

463580

LYN
Tyrosine-protein kinase Lyn

1

9

High-throughput

0.479

High

537322

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

541546

FGFR1
Fibroblast growth factor receptor 1

1

12

High-throughput

0.479

High

556145

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

562119

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

604031

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

637909

NF1
Neurofibromin

1

5

High-throughput

0.479

High

648552

FGFR4
Fibroblast growth factor receptor 4

1

12

High-throughput

0.479

High

719231

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

719337

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

730662

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731387

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

891197

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.479

High

891613

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

940992

HDAC4
Histone deacetylase 4

1

6

High-throughput

0.479

High

975086

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

1025557

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1041114

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1065714

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

2

High-throughput

0.479

High

1090143

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

6

High-throughput

0.479

High

1092444

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.479

High

1109809

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.479

High

1129954

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.479

High

1133980

ZN638
Zinc finger protein 638

1

2

High-throughput

0.479

High

1156971

NTRK3
NT-3 growth factor receptor

1

9

High-throughput

0.479

High

1216056

SPD2A
SH3 and PX domain-containing protein 2A

1

7

High-throughput

0.479

High

1219586

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1219588

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1219589

PKHA7
Pleckstrin homology domain-containing family A member 7

1

6

High-throughput

0.479

High

1219590

GGYF2
GRB10-interacting GYF protein 2

1

7

High-throughput

0.479

High

1219595

PHLB2
Pleckstrin homology-like domain family B member 2

1

4

High-throughput

0.479

High

1219596

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.479

High

1219597

KSR1
Kinase suppressor of Ras 1

1

7

High-throughput

0.479

High

1219599

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

1219602

F110B
Protein FAM110B

1

3

High-throughput

0.479

High

1219606

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1219608

GOGA1
Golgin subfamily A member 1

1

3

High-throughput

0.479

High

1219611

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.479

High

1219613

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1219614

F110A
Protein FAM110A

1

3

High-throughput

0.479

High

1219615

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.479

High

1219616

RTKN
Rhotekin

1

2

High-throughput

0.479

High

1219619

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.479

High

1219620

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1219625

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

3

High-throughput

0.479

High

1219628

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.479

High

1219629

CING
Cingulin

1

4

High-throughput

0.479

High

1219632

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1219633

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1219635

NGAP
Ras GTPase-activating protein nGAP

1

5

High-throughput

0.479

High

1219636

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1219639

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1219641

ALK
ALK tyrosine kinase receptor

1

8

High-throughput

0.479

High

1219643

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.479

High

1219644

LAMP3
Lysosome-associated membrane glycoprotein 3

1

6

High-throughput

0.479

High

1219646

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1219647

STA13
StAR-related lipid transfer protein 13

1

5

High-throughput

0.479

High

1219648

KCTD3
BTB/POZ domain-containing protein KCTD3

1

5

High-throughput

0.479

High

247352

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

390613

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

402378

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.458

High

459630

PROF1
Profilin-1

1

0

High-throughput

0.458

High

642927

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

876892

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

1208540

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

58834

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

5

High-throughput

0.445

High

516346

CALM1
Calmodulin-1

1

6

High-throughput

0.445

High

516421

CALM2
Calmodulin-2

1

6

High-throughput

0.445

High

516533

CALM3
Calmodulin-3

1

6

High-throughput

0.445

High

245237

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

5

High-throughput

0.437

High

588901

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

719021

WEE1
Wee1-like protein kinase

1

2

High-throughput

0.437

High

1151993

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

High-throughput

0.437

High

1215998

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.437

High

1219587

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.437

High

1219591

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1219592

SYDE1
Rho GTPase-activating protein SYDE1

1

7

High-throughput

0.437

High

1219601

NAV1
Neuron navigator 1

1

2

High-throughput

0.437

High

1219604

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

9

High-throughput

0.437

High

1219605

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.437

High

1219607

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.437

High

1219612

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.437

High

1219617

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.437

High

1219622

TANC2
Protein TANC2

1

2

High-throughput

0.437

High

1219624

KI13B
Kinesin-like protein KIF13B

1

6

High-throughput

0.437

High

1219627

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1219634

XPO7
Exportin-7

1

5

High-throughput

0.437

High

1219638

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

1219640

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.437

High

563894

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1219630

VGLU2
Vesicular glutamate transporter 2

1

0

High-throughput

0.426

High

1219631

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.426

High

1219645

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

0

High-throughput

0.426

High

1219593

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.407

High

139895

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

246667

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

1219609

PF21A
PHD finger protein 21A

1

0

High-throughput

0.249

Low

1219623

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

1219600

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025