HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: RHOJ (Q9H4E5)
Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein)
Gene: RHOJ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 214
+	Hs
		894026 ARHG6_HUMAN (1-776): 0: 621: 100.00		CDC42_HUMAN (20-204): 2.24e-92: 270: 63.78
+	Hs
		925289 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC1_HUMAN (22-214): 4.7e-82: 243: 57.51
+	Hs
		545388 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC2_HUMAN (22-214): 1.98e-78: 235: 57.51
+	Hs
		564535 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOQ_HUMAN (22-213): 5.09e-77: 231: 79.49
+	Hs
		892381 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC3_HUMAN (22-195): 2.97e-77: 231: 62.64
+	Gg
		1141019 ARHG6_CHICK (1-775): 0: 589: 73.55		Q6LC82_CHICK (22-214): 4.7e-82: 243: 57.51
+	Hs
		893997 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		CDC42_HUMAN (20-204): 2.24e-92: 270: 63.78
+	Hs
		1049733 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOJ_HUMAN (1-214): 2.19e-84: 250: 100.00
+	Hs
		925271 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC1_HUMAN (22-214): 4.7e-82: 243: 57.51
+	Hs
		545368 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC2_HUMAN (22-214): 1.98e-78: 235: 57.51
+	Hs
		564524 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOQ_HUMAN (22-213): 5.09e-77: 231: 79.49
+	Hs
		892365 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC3_HUMAN (22-195): 2.97e-77: 231: 62.64
+	Hs
		548671 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		CDC42_HUMAN (20-204): 2.24e-92: 270: 63.78
+	Hs
		925718 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RAC1_HUMAN (22-214): 4.7e-82: 243: 57.51
+	Hs
		901037 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RHOA_HUMAN (23-214): 1.09e-80: 240: 47.92
+	Hs
		951449 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RHOG_HUMAN (20-214): 1.44e-78: 235: 50.26
+	Hs
		855778 VAV2_HUMAN (1-746): 1.37e-111: 361: 15.14		CDC42_HUMAN (20-204): 2.24e-92: 270: 63.78
+	Hs
		548678 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		RAC1_HUMAN (22-214): 4.7e-82: 243: 57.51
+	Hs
		548672 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		RHOA_HUMAN (23-214): 1.09e-80: 240: 47.92
+	Hs
		855779 VAV2_HUMAN (1-746): 1.37e-111: 361: 15.14		RHOA_HUMAN (23-214): 1.09e-80: 240: 47.92