Protein: P5CS
Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]

Gene: P5CS, ALDH18A1
Organism: Homo sapiens
Interactions: 173
UniProt ID: P54886

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004349 - glutamate 5-kinase activity
GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873393

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

15

High-throughput

0.618

High

841110

CDK7
Cyclin-dependent kinase 7

2

2

High-throughput

0.611

High

346328

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.599

High

226973

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

377207

GCR
Glucocorticoid receptor

2

5

Small-scale

0.584

High

258424

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

0

High-throughput

0.580

High

873437

SYDM
Aspartate--tRNA ligase, mitochondrial

2

0

High-throughput

0.580

High

506446

RALB
Ras-related protein Ral-B

2

4

High-throughput

0.574

High

322376

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

873411

CUL3
Cullin-3

2

4

High-throughput

0.558

High

873495

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.549

High

873402

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

873414

ICT1
Large ribosomal subunit protein mL62

1

3

High-throughput

0.536

High

873424

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

873448

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

873459

CERK1
Ceramide kinase

1

1

High-throughput

0.536

High

873500

TAOK2
Serine/threonine-protein kinase TAO2

1

2

High-throughput

0.536

High

779092

CCNF
Cyclin-F

2

8

High-throughput

0.533

High

873487

ANLN
Anillin

2

2

High-throughput

0.533

High

369250

ESR1
Estrogen receptor

2

5

High-throughput

0.521

High

873403

SOS2
Son of sevenless homolog 2

2

2

High-throughput

0.521

High

873454

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

873460

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

2

4

High-throughput

0.521

High

873462

ARH40
Rho guanine nucleotide exchange factor 40

2

2

High-throughput

0.521

High

609777

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

873436

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

873498

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

873503

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

121462

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

5

High-throughput

0.489

High

257963

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.489

High

451403

CLCA
Clathrin light chain A

1

3

High-throughput

0.489

High

451656

CLCB
Clathrin light chain B

1

2

High-throughput

0.489

High

873434

L2GL2
LLGL scribble cell polarity complex component 2

1

5

High-throughput

0.489

High

873470

GCP5
Gamma-tubulin complex component 5

1

1

High-throughput

0.489

High

148577

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

262767

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

294581

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

373936

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

384560

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.479

High

440435

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

499648

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

503757

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

513976

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

572607

VGFR1
Vascular endothelial growth factor receptor 1

1

6

High-throughput

0.479

High

625266

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

738182

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.479

High

822446

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.479

High

873394

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

873397

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

873400

VIGLN
Vigilin

1

1

High-throughput

0.479

High

873401

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

873408

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

873412

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

873419

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

873420

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

873421

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

873432

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

873439

KAT3
Kynurenine--oxoglutarate transaminase 3

1

4

High-throughput

0.479

High

873449

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

4

High-throughput

0.479

High

873463

FBXW7
F-box/WD repeat-containing protein 7

1

7

High-throughput

0.479

High

873472

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

873474

TR61B
tRNA

1

1

High-throughput

0.479

High

873491

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

9

Small-scale

0.479

High

873493

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

873505

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

4

Small-scale

0.479

High

329539

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.470

High

873499

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.470

High

62908

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

165429

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.458

High

386381

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

584911

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

713482

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

873405

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

873415

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

873423

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

873446

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

873465

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

873489

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.458

High

873496

TES
Testin

1

0

High-throughput

0.458

High

873395

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.457

High

401700

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

873399

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.445

High

873418

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

Small-scale

0.445

High

873430

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

873506

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

9

High-throughput

0.445

High

233308

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

298317

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

303046

HEXI1
Protein HEXIM1

1

1

High-throughput

0.437

High

548077

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.437

High

552334

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

650779

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720067

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

787148

RHG25
Rho GTPase-activating protein 25

1

2

High-throughput

0.437

High

792946

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

6

High-throughput

0.437

High

873398

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

8

High-throughput

0.437

High

873404

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

873406

DPYD
Dihydropyrimidine dehydrogenase [NADP(+)]

1

1

High-throughput

0.437

High

873407

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

3

High-throughput

0.437

High

873409

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.437

High

873410

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.437

High

873413

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

873425

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.437

High

873427

SMU1
WD40 repeat-containing protein SMU1

1

7

High-throughput

0.437

High

873428

ANR55
Ankyrin repeat domain-containing protein 55

1

4

High-throughput

0.437

High

873431

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

873441

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

873442

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

873444

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

873447

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

873452

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

873453

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.437

High

873455

ARL10
ADP-ribosylation factor-like protein 10

1

3

High-throughput

0.437

High

873458

COP1
E3 ubiquitin-protein ligase COP1

1

9

High-throughput

0.437

High

873461

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

873466

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.437

High

873469

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

873471

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.437

High

873475

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.437

High

873476

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

873479

RHG39
Rho GTPase-activating protein 39

1

4

High-throughput

0.437

High

873482

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.437

High

873483

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.437

High

873484

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

873485

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

873488

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.437

High

873492

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.437

High

873497

UBQL2
Ubiquilin-2

1

4

High-throughput

0.437

High

873501

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

873502

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.437

High

275393

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

873417

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

239880

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

371384

ANGI
Angiogenin

1

1

High-throughput

0.407

High

873478

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.407

High

873438

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

873467

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.299

High

873457

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.298

High

63920

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.279

Low

813270

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

873422

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

0

High-throughput

0.279

Low

873426

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.279

Low

873435

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.279

Low

873440

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

873443

HAKAI
E3 ubiquitin-protein ligase Hakai

1

0

Small-scale

0.279

Low

873445

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

0

High-throughput

0.279

Low

873468

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.279

Low

873477

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

873480

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.279

Low

873481

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.279

Low

873486

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.279

Low

873494

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.279

Low

873504

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

67694

SYC1L
Synaptonemal complex central element protein 1-like

1

0

High-throughput

0.251

Low

119281

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

122586

MEN1
Menin

1

0

High-throughput

0.249

Low

278003

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.249

Low

351320

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.249

Low

428985

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

551488

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.249

Low

823755

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

830853

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

873396

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.249

Low

873416

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

873429

AKIR2
Akirin-2

1

0

Small-scale

0.249

Low

873433

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

873450

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

Small-scale

0.249

Low

873451

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

873456

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

873464

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.249

Low

873473

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

873490

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

581575

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024