Protein: HOMEZ
Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor)

Gene: HOMEZ
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q8IX15

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1311784

DEFI6
Differentially expressed in FDCP 6 homolog

5

3

High-throughput

0.723

High

1311750

SMYD1
Histone-lysine N-methyltransferase SMYD1

4

1

High-throughput

0.700

High

967844

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

1

High-throughput

0.667

High

1311773

MED18
Mediator of RNA polymerase II transcription subunit 18

3

0

High-throughput

0.639

High

222139

NCK2
Cytoplasmic protein NCK2

2

10

High-throughput

0.633

High

302577

RNF8
E3 ubiquitin-protein ligase RNF8

2

7

High-throughput

0.633

High

471882

RU2B
U2 small nuclear ribonucleoprotein B''

2

7

High-throughput

0.633

High

749070

RL9
Large ribosomal subunit protein uL6

2

1

High-throughput

0.633

High

930748

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

2

High-throughput

0.633

High

964357

SUMO2
Small ubiquitin-related modifier 2

2

8

High-throughput

0.633

High

1061768

TLE5
TLE family member 5

2

20

High-throughput

0.633

High

1109316

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.633

High

1124363

ELOA1
Elongin-A

2

2

High-throughput

0.633

High

1311758

AEN
Apoptosis-enhancing nuclease

2

2

High-throughput

0.633

High

1311775

TRAF4
TNF receptor-associated factor 4

2

6

High-throughput

0.633

High

1311783

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

2

3

High-throughput

0.633

High

1150205

TEAD4
Transcriptional enhancer factor TEF-3

2

4

High-throughput

0.613

High

1311754

LNX1
E3 ubiquitin-protein ligase LNX

3

1

High-throughput

0.609

High

140345

SDCB1
Syntenin-1

2

0

High-throughput

0.606

High

1136745

MD2BP
MAD2L1-binding protein

2

0

High-throughput

0.606

High

1311747

CENPS
Centromere protein S

2

0

High-throughput

0.606

High

1311794

COE1
Transcription factor COE1

2

0

High-throughput

0.606

High

691225

1433T
14-3-3 protein theta

2

8

High-throughput

0.601

High

730038

1433B
14-3-3 protein beta/alpha

2

8

High-throughput

0.601

High

966587

1433G
14-3-3 protein gamma

2

8

High-throughput

0.601

High

990469

1433Z
14-3-3 protein zeta/delta

2

8

High-throughput

0.601

High

1049532

1433F
14-3-3 protein eta

2

8

High-throughput

0.601

High

1165466

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

2

4

High-throughput

0.601

High

474115

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

1311757

SH3R2
E3 ubiquitin-protein ligase SH3RF2

2

2

High-throughput

0.584

High

1311769

LRRC7
Leucine-rich repeat-containing protein 7

2

1

High-throughput

0.584

High

1311800

RM11
Large ribosomal subunit protein uL11m

2

1

High-throughput

0.578

High

334569

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

2

High-throughput

0.573

High

910978

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.573

High

987757

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.573

High

1095406

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.573

High

1126991

RBM39
RNA-binding protein 39

1

5

High-throughput

0.573

High

252110

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.549

High

1086628

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

907657

KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

1

0

High-throughput

0.513

High

1146246

ZMY11
Zinc finger MYND domain-containing protein 11

1

15

High-throughput

0.501

High

66376

ZSA5B
Zinc finger and SCAN domain-containing protein 5B

1

9

High-throughput

0.481

High

132493

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.481

High

181141

AXIN1
Axin-1

1

2

High-throughput

0.481

High

193346

MAFG
Transcription factor MafG

1

5

High-throughput

0.481

High

210309

PHF1
PHD finger protein 1

1

5

High-throughput

0.481

High

238917

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

1

High-throughput

0.481

High

297009

CCNK
Cyclin-K

1

1

High-throughput

0.481

High

505736

ZN688
Zinc finger protein 688

1

5

High-throughput

0.481

High

567179

ZNF35
Zinc finger protein 35

1

3

High-throughput

0.481

High

570491

GFAP
Glial fibrillary acidic protein

1

9

High-throughput

0.481

High

594041

NCK1
SH2/SH3 adapter protein NCK1

1

10

High-throughput

0.481

High

648370

USF1
Upstream stimulatory factor 1

1

7

High-throughput

0.481

High

664387

ZBT25
Zinc finger and BTB domain-containing protein 25

1

10

High-throughput

0.481

High

680940

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.481

High

682061

RBTN1
Rhombotin-1

1

19

High-throughput

0.481

High

703641

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.481

High

783723

ZNF76
Zinc finger protein 76

1

4

High-throughput

0.481

High

840918

TXK
Tyrosine-protein kinase TXK

1

7

High-throughput

0.481

High

892409

ZN165
Zinc finger protein 165

1

8

High-throughput

0.481

High

939208

SUMO3
Small ubiquitin-related modifier 3

1

8

High-throughput

0.481

High

940786

LEG4
Galectin-4

1

1

High-throughput

0.481

High

982992

RS25
Small ribosomal subunit protein eS25

1

1

High-throughput

0.481

High

1119753

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

2

High-throughput

0.481

High

1120680

VEZF1
Vascular endothelial zinc finger 1

1

4

High-throughput

0.481

High

1136812

MO4L2
Mortality factor 4-like protein 2

1

1

High-throughput

0.481

High

1150121

TCEA2
Transcription elongation factor A protein 2

1

3

High-throughput

0.481

High

1213567

PHF19
PHD finger protein 19

1

5

High-throughput

0.481

High

1234856

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.481

High

1247946

ANR11
Ankyrin repeat domain-containing protein 11

1

9

High-throughput

0.481

High

1311749

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

1

4

High-throughput

0.481

High

1311751

Z280C
Zinc finger protein 280C

1

5

High-throughput

0.481

High

1311752

LMO3
LIM domain only protein 3

1

18

High-throughput

0.481

High

1311755

CCHCR
Coiled-coil alpha-helical rod protein 1

1

5

High-throughput

0.481

High

1311759

PIBF1
Progesterone-induced-blocking factor 1

1

2

High-throughput

0.481

High

1311760

RSLAA
Ras-like protein family member 10A

1

3

High-throughput

0.481

High

1311767

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

9

High-throughput

0.481

High

1311772

RHG09
Rho GTPase-activating protein 9

1

3

High-throughput

0.481

High

1311780

IN80B
INO80 complex subunit B

1

1

High-throughput

0.481

High

1311781

ANKR2
Ankyrin repeat domain-containing protein 2

1

6

High-throughput

0.481

High

1311786

CBX8
Chromobox protein homolog 8

1

5

High-throughput

0.481

High

1311787

NEK6
Serine/threonine-protein kinase Nek6

1

3

High-throughput

0.481

High

1311789

ASB6
Ankyrin repeat and SOCS box protein 6

1

3

High-throughput

0.481

High

1311790

ARP10
Actin-related protein 10

1

3

High-throughput

0.481

High

1311797

ZN580
Zinc finger protein 580

1

8

High-throughput

0.481

High

1311799

TBC30
TBC1 domain family member 30

1

1

High-throughput

0.481

High

143106

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

181534

TBXT
T-box transcription factor T

1

16

High-throughput

0.479

High

210048

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

225058

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

538434

EGR2
E3 SUMO-protein ligase EGR2

1

6

High-throughput

0.479

High

685259

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

725284

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

872508

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

887012

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.479

High

895751

LHX2
LIM/homeobox protein Lhx2

1

19

High-throughput

0.479

High

938475

PAX9
Paired box protein Pax-9

1

19

High-throughput

0.479

High

979951

H4
Histone H4

1

3

High-throughput

0.479

High

1017007

H33
Histone H3.3

1

6

High-throughput

0.479

High

1087858

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1133519

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1311748

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.479

High

1311756

SP7
Transcription factor Sp7

1

14

High-throughput

0.479

High

1311762

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

2

Small-scale

0.479

High

1311770

FEV
Protein FEV

1

17

High-throughput

0.479

High

1311792

ZMYM2
Zinc finger MYM-type protein 2

1

6

High-throughput

0.479

High

50952

A1L1C6
LRRC7 protein

1

3

High-throughput

0.470

High

1066050

Q08AM8
E3 ubiquitin-protein ligase SH3RF2

1

2

High-throughput

0.470

High

269273

HSF2B
Heat shock factor 2-binding protein

1

0

High-throughput

0.460

High

353710

DRC4
Dynein regulatory complex subunit 4

1

0

High-throughput

0.460

High

585066

ZN250
Zinc finger protein 250

1

0

High-throughput

0.460

High

1118910

BYST
Bystin

1

0

High-throughput

0.460

High

1120863

DGCR6
Protein DGCR6

1

0

High-throughput

0.460

High

1148909

SC23A
Protein transport protein Sec23A

1

0

High-throughput

0.460

High

1288061

BIVM
Basic immunoglobulin-like variable motif-containing protein

1

0

High-throughput

0.460

High

1311753

ZN417
Zinc finger protein 417

1

0

High-throughput

0.460

High

1311763

NEIL2
Endonuclease 8-like 2

1

0

High-throughput

0.460

High

1311765

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.460

High

1311771

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.460

High

1311774

RPP25
Ribonuclease P protein subunit p25

1

0

High-throughput

0.460

High

1311778

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.460

High

1311779

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.460

High

1311788

CB042
Uncharacterized protein C2orf42

1

0

High-throughput

0.460

High

1311791

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.460

High

1311793

ZN629
Zinc finger protein 629

1

0

High-throughput

0.460

High

1311798

VP9D1
VPS9 domain-containing protein 1

1

0

High-throughput

0.460

High

1311801

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.460

High

1277178

POGZ
Pogo transposable element with ZNF domain

1

5

High-throughput

0.445

High

1311768

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

20

High-throughput

0.445

High

350481

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

2

High-throughput

0.439

High

1295059

F90A1
Protein FAM90A1

1

1

High-throughput

0.439

High

1311745

CCD13
Coiled-coil domain-containing protein 13

1

5

High-throughput

0.439

High

1311764

JKIP2
Janus kinase and microtubule-interacting protein 2

1

4

High-throughput

0.439

High

1311776

KIFC3
Kinesin-like protein KIFC3

1

1

High-throughput

0.439

High

1311777

SYTM
Threonine--tRNA ligase, mitochondrial

1

1

High-throughput

0.439

High

1311785

PARVG
Gamma-parvin

1

8

High-throughput

0.439

High

1311795

CTNA3
Catenin alpha-3

1

2

High-throughput

0.439

High

1311761

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

0

High-throughput

0.282

High

334437

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.251

Low

364158

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

0

High-throughput

0.251

Low

1187651

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.251

Low

1309191

Q8IVT4
Hypothetical MGC50722

1

0

High-throughput

0.251

Low

1311746

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.251

Low

1311766

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.251

Low

1311782

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.251

Low

1311796

OSGI1
Oxidative stress-induced growth inhibitor 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025