HitPredict

Interactor 1: CDK10 (Q15131)
Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE)
Gene: CDK10

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 376
+	Hs
		625278 CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		625338 CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43		ACTG_HUMAN (3-376): 0: 595: 91.44
+	Hs
		625343 CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43		ACTS_HUMAN (2-376): 0: 590: 87.47
+	Hs
		891779 CDK10_HUMAN (1-360): 4.23e-136: 393: 100.00		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		915388 CDK10_HUMAN (1-360): 4.23e-136: 393: 100.00		ACTA_HUMAN (1-376): 0: 588: 87.80
+	Hs
		841152 CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91		ACTG_HUMAN (3-376): 0: 595: 91.44
+	Hs
		841154 CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91		ACTC_HUMAN (2-376): 0: 590: 88.27
+	Hs
		841156 CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91		ACTS_HUMAN (2-376): 0: 590: 87.47