Protein: RRP4
Exosome complex component rrp4 (Ribosomal RNA-processing protein 4)

Gene: RRP4
Organism: Schizosaccharomyces pombe 972h-
Interactions: 229
UniProt ID: Q09704

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000785 - chromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1068422

RRP43
Exosome complex component rrp43

2

20

Small-scale

0.754

High

789292

DIS3
Exosome complex exonuclease dis3

3

5

Small-scale

0.640

High

149415

DED1
ATP-dependent RNA helicase ded1

1

1

High-throughput

0.618

High

150457

MS116
ATP-dependent RNA helicase mss116, mitochondrial

1

4

High-throughput

0.618

High

151565

YE02
Uncharacterized helicase C17H9.02

1

6

High-throughput

0.618

High

151943

RRP40
Exosome complex component rrp40

1

5

High-throughput

0.618

High

153553

MTR4
ATP-dependent RNA helicase mtr4

1

6

High-throughput

0.618

High

206877

RRP41
Exosome complex component ski6

1

20

High-throughput

0.618

High

206903

RRP46
Exosome complex component rrp46

1

17

High-throughput

0.618

High

237816

CSL4
Exosome complex component csl4

1

3

High-throughput

0.618

High

237958

DBP9
ATP-dependent RNA helicase dbp9

1

1

High-throughput

0.618

High

238044

RRP42
Exosome complex component rrp42

1

20

High-throughput

0.618

High

238263

DBP7
ATP-dependent RNA helicase dbp7

1

3

High-throughput

0.618

High

267565

MAK5
ATP-dependent RNA helicase mak5

1

2

High-throughput

0.618

High

268301

RRP5
rRNA biogenesis protein rrp5

1

1

High-throughput

0.618

High

268495

RRP45
Exosome complex component rrp45

1

20

High-throughput

0.618

High

510990

TLH1
ATP-dependent DNA helicase tlh1

1

5

High-throughput

0.618

High

1068404

DBP10
ATP-dependent RNA helicase dbp10

1

1

High-throughput

0.618

High

1068409

ROK1
ATP-dependent RNA helicase rok1

1

2

High-throughput

0.618

High

1068416

HAS1
ATP-dependent RNA helicase has1

1

2

High-throughput

0.618

High

1068429

CDC28
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28

1

1

High-throughput

0.618

High

1068455

MTR3
Exosome complex component mtr3

1

20

High-throughput

0.618

High

152715

MPP6
M-phase phosphoprotein 6 homolog

1

0

High-throughput

0.586

High

666387

DBP2
ATP-dependent RNA helicase dbp2

1

0

High-throughput

0.586

High

940514

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.586

High

1068471

RED1
NURS complex subunit red1

2

1

High-throughput

0.584

High

153732

YFPE
Uncharacterized protein C7D4.14c

2

0

High-throughput

0.559

High

1042333

PRH1
Probable ATP-dependent RNA helicase prh1

1

1

High-throughput

0.553

High

150434

PRP46
Pre-mRNA-splicing factor prp5

1

3

High-throughput

0.479

High

151745

IMP4
U3 small nucleolar ribonucleoprotein protein imp4

1

1

High-throughput

0.479

High

151955

MPP10
U3 small nucleolar ribonucleoprotein protein mpp10

1

1

High-throughput

0.479

High

152399

SGD1
Suppressor of glycerol defect protein 1

1

3

High-throughput

0.479

High

152488

CBF5
H/ACA ribonucleoprotein complex subunit cbf5

1

1

High-throughput

0.479

High

152683

UTP21
U3 small nucleolar RNA-associated protein 21 homolog

1

5

High-throughput

0.479

High

153848

YB7A
Uncharacterized AAA domain-containing protein C16E9.10c

1

2

High-throughput

0.479

High

153925

RM07
Large ribosomal subunit protein uL5m

1

1

High-throughput

0.479

High

153930

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

154019

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.479

High

154269

EF2
Elongation factor 2

1

1

High-throughput

0.479

High

206122

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

206888

FCF2
rRNA-processing protein fcf2

1

1

High-throughput

0.479

High

207108

RL16B
Large ribosomal subunit protein uL13B

1

1

High-throughput

0.479

High

207210

NOP14
Probable nucleolar complex protein 14

1

1

High-throughput

0.479

High

237764

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.479

High

237860

HSP72
Probable heat shock protein ssa2

1

2

High-throughput

0.479

High

237911

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

237947

YBB9
Uncharacterized protein C13G1.09

1

1

High-throughput

0.479

High

238061

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

238188

RL7C
Large ribosomal subunit protein uL30C

1

2

High-throughput

0.479

High

267398

RL5B
Large ribosomal subunit protein uL18B

1

1

High-throughput

0.479

High

267485

DCA13
Protein sof1

1

5

High-throughput

0.479

High

267639

UBP16
Probable ubiquitin carboxyl-terminal hydrolase 16

1

1

High-throughput

0.479

High

267722

YQC7
Exosome complex protein C1739.07

1

1

High-throughput

0.479

High

267851

RL27B
Large ribosomal subunit protein eL27B

1

1

High-throughput

0.479

High

267962

CFT1
Protein cft1

1

1

High-throughput

0.479

High

268090

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.479

High

268382

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.479

High

268408

NOL10
Ribosome biogenesis protein enp2 homolog

1

1

High-throughput

0.479

High

268437

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

313597

NOP2
25S rRNA

1

1

High-throughput

0.479

High

313947

UTP15
U3 small nucleolar RNA-associated protein 15

1

4

High-throughput

0.479

High

314127

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.479

High

314300

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

314660

BMS1
Ribosome biogenesis protein bms1

1

1

High-throughput

0.479

High

314668

NOG1
Probable nucleolar GTP-binding protein 1

1

1

High-throughput

0.479

High

314693

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

314707

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

314802

RS15A
Small ribosomal subunit protein uS19A

1

2

High-throughput

0.479

High

480424

H4
Histone H4

1

1

High-throughput

0.479

High

505927

RS27B
Ubiquitin-ribosomal protein eS31B fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31B

1

1

High-throughput

0.479

High

583982

RPA1
DNA-directed RNA polymerase I subunit rpa1

1

2

High-throughput

0.479

High

609896

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.479

High

675368

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.479

High

701388

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

775792

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

785630

RPB1
DNA-directed RNA polymerase II subunit rpb1

1

2

High-throughput

0.479

High

944939

RL28B
Large ribosomal subunit protein uL15B

1

1

High-throughput

0.479

High

1008992

ACAC
Acetyl-CoA carboxylase

1

1

High-throughput

0.479

High

1009042

RL26
Large ribosomal subunit protein uL24

1

1

High-throughput

0.479

High

1009056

IF4E1
Eukaryotic translation initiation factor 4E-1

1

1

High-throughput

0.479

High

1017967

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

1018038

YDM6
Uncharacterized protein C57A7.06

1

1

High-throughput

0.479

High

1067045

MLO3
mRNA export protein mlo3

1

2

High-throughput

0.479

High

1068410

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

1068417

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

1068418

NEP1
Ribosomal RNA small subunit methyltransferase mra1

1

1

High-throughput

0.479

High

1068419

RRP6
Exosome complex exonuclease rrp6

1

5

High-throughput

0.479

High

1068420

RL18A
Large ribosomal subunit protein eL18A

1

1

High-throughput

0.479

High

1068421

NDC80
Kinetochore protein ndc80

1

1

High-throughput

0.479

High

1068423

RT05
Small ribosomal subunit protein uS5m

1

2

High-throughput

0.479

High

1068424

SSB1
Ribosome-associated molecular chaperone sks2

1

3

High-throughput

0.479

High

1068426

RL25A
Large ribosomal subunit protein uL23A

1

2

High-throughput

0.479

High

1068428

IF4G
Eukaryotic translation initiation factor 4 gamma

1

2

High-throughput

0.479

High

1068431

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

1068432

NOP9
Nucleolar protein 9

1

1

High-throughput

0.479

High

1068439

BRX1
Ribosome biogenesis protein brx1

1

3

High-throughput

0.479

High

1068442

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.479

High

1068445

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.479

High

1068449

RS8B
Small ribosomal subunit protein eS8B

1

1

High-throughput

0.479

High

1068450

YKU5
Uncharacterized WD repeat-containing protein C2E1P5.05

1

5

High-throughput

0.479

High

1068452

FLP1
Tyrosine-protein phosphatase CDC14 homolog

1

1

High-throughput

0.479

High

1068456

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

1068460

BFR2
Protein bfr2

1

1

High-throughput

0.479

High

1068465

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.479

High

1068470

RS15B
Small ribosomal subunit protein uS19B

1

2

High-throughput

0.479

High

267688

SFC4
Transcription factor tau subunit sfc4

1

0

High-throughput

0.460

High

149241

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.458

High

150451

MRD1
Multiple RNA-binding domain-containing protein 1

1

0

High-throughput

0.458

High

150694

SFI1
Protein sfi1

1

0

High-throughput

0.458

High

150700

FAR11
Factor arrest protein 11

1

0

High-throughput

0.458

High

150714

RL8
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

151157

NOP12
Nucleolar protein 12

1

0

High-throughput

0.458

High

152447

YEG5
Ankyrin and IPT/TIG repeat-containing protein C26H5.05

1

0

High-throughput

0.458

High

152659

PNO1
Pre-rRNA-processing protein pno1

1

0

High-throughput

0.458

High

152736

RPA49
DNA-directed RNA polymerase I subunit rpa49

1

0

High-throughput

0.458

High

152812

PSD3
Phosphatidylserine decarboxylase proenzyme 3

1

0

High-throughput

0.458

High

205796

YEK9
Uncharacterized protein C4F10.09c

1

0

High-throughput

0.458

High

206114

RL34A
Large ribosomal subunit protein eL34A

1

0

High-throughput

0.458

High

207054

PAT1
Deadenylation-dependent mRNA-decapping factor pdc2

1

0

High-throughput

0.458

High

207080

NRDE2
Protein NRDE2 homolog

1

0

High-throughput

0.458

High

237552

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.458

High

237874

RS24B
Small ribosomal subunit protein eS24B

1

0

High-throughput

0.458

High

238010

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

238249

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

238285

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.458

High

267343

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

267373

FKBP4
FK506-binding protein 39 kDa

1

0

High-throughput

0.458

High

267469

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

267581

YOCE
Uncharacterized RNA-binding protein C4F6.14

1

0

High-throughput

0.458

High

267586

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

268115

GRN1
GTPase grn1

1

0

High-throughput

0.458

High

268203

YBJC
Zinc finger CCCH domain-containing protein C337.12

1

0

High-throughput

0.458

High

268463

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

268738

MMI1
RNA binding exosome specificity factor Mmi1

1

0

High-throughput

0.458

High

313527

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

313555

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

313795

PIR2
NURS complex subunit pir2

1

0

High-throughput

0.458

High

314023

REXO4
RNA exonuclease 4

1

0

High-throughput

0.458

High

314066

YQFB
Uncharacterized RNA-binding protein C126.11c

1

0

High-throughput

0.458

High

314345

ALP14
Spindle pole body component alp14

1

0

High-throughput

0.458

High

419308

H2A2
Histone H2A-beta

1

0

High-throughput

0.458

High

419931

H2B1
Histone H2B-alpha

1

0

High-throughput

0.458

High

432426

RL19A
Large ribosomal subunit protein eL19A

1

0

High-throughput

0.458

High

605536

RYH1
GTP-binding protein ryh1

1

0

High-throughput

0.458

High

772234

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

823534

RL3A
Large ribosomal subunit protein uL3A

1

0

High-throughput

0.458

High

836493

GAR2
Protein gar2

1

0

High-throughput

0.458

High

896096

SSP1
Serine/threonine-protein kinase ssp1

1

0

High-throughput

0.458

High

914566

RL30A
Large ribosomal subunit protein eL30A

1

0

High-throughput

0.458

High

1009050

BUD4
Anillin-related medial ring protein mid1

1

0

High-throughput

0.458

High

1009063

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

0

High-throughput

0.458

High

1009123

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

1018228

HIR3
Histone transcription regulator 3 homolog

1

0

High-throughput

0.458

High

1066861

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.458

High

1068348

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

1068407

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

1068408

GEF1
Rho guanine nucleotide exchange factor gef1

1

0

High-throughput

0.458

High

1068411

KRI1
Protein kri1

1

0

High-throughput

0.458

High

1068413

EFG1P
rRNA-processing protein efg1

1

0

High-throughput

0.458

High

1068425

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.458

High

1068427

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.458

High

1068430

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.458

High

1068434

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

1068438

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit Tra1

1

0

High-throughput

0.458

High

1068440

RL43A
Large ribosomal subunit protein eL43A

1

0

High-throughput

0.458

High

1068447

AIR1
Protein air1

1

0

High-throughput

0.458

High

1068448

YN84
Uncharacterized protein P35G2.04c

1

0

High-throughput

0.458

High

1068451

ACON2
Aconitase-ribosomal protein bL21m fusion protein [Includes: Homocitrate dehydratase, mitochondrial

1

0

High-throughput

0.458

High

1068453

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.458

High

1068457

SIB1
Hydroxamate-type ferrichrome siderophore peptide synthetase

1

0

High-throughput

0.458

High

1068459

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1068462

YHP4
Uncharacterized RNA-binding protein C902.04

1

0

High-throughput

0.458

High

1068463

RL38A
Large ribosomal subunit protein eL38A

1

0

High-throughput

0.458

High

1068464

ATH1
Ataxin-2 homolog

1

0

High-throughput

0.458

High

1068466

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.458

High

1068469

CID14
Poly(A) RNA polymerase cid14

1

0

High-throughput

0.458

High

1068472

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.458

High

1068473

PIF1
ATP-dependent DNA helicase pfh1

1

0

High-throughput

0.458

High

1068474

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.458

High

1068475

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.458

High

1068478

RML2
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.458

High

238279

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

267561

RL25B
Large ribosomal subunit protein uL23B

1

2

High-throughput

0.437

High

267664

SCW1
Cell wall integrity protein scw1

1

1

High-throughput

0.437

High

313950

YG06
Uncharacterized protein C1604.06c

1

2

High-throughput

0.437

High

785598

RL28A
Large ribosomal subunit protein uL15A

1

1

High-throughput

0.437

High

1008952

UTP18
Probable U3 small nucleolar RNA-associated protein 18

1

3

High-throughput

0.437

High

1068414

RCL1
rRNA processing protein rcl1

1

1

High-throughput

0.437

High

1068435

YHU2
Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02

1

1

High-throughput

0.437

High

1068441

UTP7
Probable U3 small nucleolar RNA-associated protein 7

1

6

High-throughput

0.437

High

1068443

RM09
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.437

High

1068461

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.437

High

1068467

IMG1
Large ribosomal subunit protein bL19m

1

1

High-throughput

0.437

High

1068468

CO111
Rsm22-cox11 tandem protein 1, mitochondrial [Cleaved into: Ribosome assembly protein Rsm22-1; Cytochrome c oxidase assembly protein cox11-1]

1

1

High-throughput

0.437

High

91444

RM49
Large ribosomal subunit protein mL61

1

0

High-throughput

0.249

Low

107769

TAM12
Uncharacterized protein tam12

1

0

High-throughput

0.249

Low

150408

RT28
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.249

Low

150918

YDYB
PH and SEC7 domain-containing protein C11E3.11c

1

0

High-throughput

0.249

Low

152396

RT04
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.249

Low

153377

RM28
Large ribosomal subunit protein mL40

1

0

High-throughput

0.249

Low

153379

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.249

Low

153572

RAX2
Polarized growth protein rax2

1

0

High-throughput

0.249

Low

205782

LIPB
Probable octanoyltransferase

1

0

High-throughput

0.249

Low

237869

RM33
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.249

Low

237967

RT35
Small ribosomal subunit protein mS45

1

0

High-throughput

0.249

Low

267554

YNV8
Uncharacterized protein C3H7.08c

1

0

High-throughput

0.249

Low

268094

MMB1
Microtubule-associated protein mmb1

1

0

High-throughput

0.249

Low

314062

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.249

Low

314235

MBO1
Gamma tubulin complex adapter mto1

1

0

High-throughput

0.249

Low

358434

ADH
Alcohol dehydrogenase

1

0

High-throughput

0.249

Low

484809

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.249

Low

654007

KIN1
Protein kinase kin1

1

0

High-throughput

0.249

Low

785766

ILVB
Acetolactate synthase, mitochondrial

1

0

High-throughput

0.249

Low

785769

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.249

Low

1018102

DIMI
Mitosis protein dim1

1

0

High-throughput

0.249

Low

1068403

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

1068405

MRP20
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

1068406

CP51
Lanosterol 14-alpha demethylase erg11

1

0

High-throughput

0.249

Low

1068412

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.249

Low

1068415

ATCX
Phospholipid-transporting ATPase dnf2

1

0

High-throughput

0.249

Low

1068433

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.249

Low

1068436

YOM2
Uncharacterized protein PB7E8.02

1

0

High-throughput

0.249

Low

1068437

YKP9
CRAL-TRIO domain-containing protein C589.09, mitochondrial

1

0

High-throughput

0.249

Low

1068444

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

1068446

YNY5
LisH domain-containing protein C1711.05

1

0

High-throughput

0.249

Low

1068454

NOP10
H/ACA ribonucleoprotein complex subunit nop10

1

0

High-throughput

0.249

Low

1068458

RPA2
Probable DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.249

Low

1068476

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.249

Low

1068477

MOK12
Cell wall alpha-1,3-glucan synthase mok12

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025