HitPredict

Interactor 1: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Interactor 2: AAK1 (Q2M2I8)
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
Gene: AAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27173435, 36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 4684 Hs			1 961
+	Hs
		1068680 PLEC_HUMAN (1-4684): 0: 1783: 100.00		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		623875 PLEC_HUMAN (1-4684): 0: 1783: 100.00		KPCL_HUMAN (1-390): 1.79e-116: 374: 18.47
+	Mm
		949310 Q68FG2_MOUSE (1390-3166): 7.42e-23: 111: 11.85		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		963449 SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53		TNIK_HUMAN (24-770): 5.75e-117: 391: 15.27
+	Mm
		949304 SPTB2_MOUSE (1531-3013): 1.72e-17: 93.1: 9.54		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Dm
		1182583 Q7KV69_DROME (995-2857): 1.68e-21: 106: 13.16		Q9VJ30_DROME (1-634): 1.29e-110: 375: 36.12
+	Rn
		1144340 SPTN2_RAT (1390-3173): 3.99e-23: 112: 11.92		AKT3_RAT (8-386): 1.49e-116: 367: 17.81
+	Hs
		974168 DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51		TNIK_HUMAN (24-770): 5.75e-117: 391: 15.27
+	Hs
		1356411 MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92		TNIK_HUMAN (24-770): 5.75e-117: 391: 15.27
+	Mm
		949420 MACF1_MOUSE (4303-4628): 3.44e-09: 66.2: 16.56		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Mm
		949395 DYST_MOUSE (4325-4624): 7.75e-09: 65: 17.00		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		647985 MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92		MARK3_HUMAN (2-692): 2.26e-119: 383: 14.89
+	Mm
		251106 DYST_MOUSE (4325-4624): 7.75e-09: 65: 17.00		CSKP_MOUSE (43-677): 4.34e-116: 379: 16.03
+	Hs
		551616 DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Hs
		161658 GOGB1_HUMAN (2666-3718): 4.33e-13: 78.9: 11.65		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Hs
		851355 SPTN4_HUMAN (1394-3173): 6.68e-13: 78.1: 10.95		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41