Protein: SIPA1
Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1)

Gene: SIPA1
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q96FS4

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1390852

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.698

High

244600

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

9

High-throughput

0.691

High

968404

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.691

High

1390855

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

8

High-throughput

0.691

High

691327

1433T
14-3-3 protein theta

3

20

High-throughput

0.643

High

730139

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.643

High

159391

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

14

High-throughput

0.621

High

389473

FINC
Fibronectin

1

3

High-throughput

0.618

High

962371

RHOA
Transforming protein RhoA

1

17

High-throughput

0.618

High

988604

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.618

High

966730

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

990595

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.601

High

1049657

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

708864

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

4

High-throughput

0.575

High

808142

CDN1A
Cyclin-dependent kinase inhibitor 1

1

3

High-throughput

0.552

High

567218

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.546

High

260292

BRD4
Bromodomain-containing protein 4

1

0

Small-scale

0.537

High

123800

MYO1C
Unconventional myosin-Ic

1

3

High-throughput

0.536

High

396697

ESR1
Estrogen receptor

1

8

High-throughput

0.536

High

772955

MYH9
Myosin-9

1

1

High-throughput

0.536

High

862933

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.536

High

866780

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

1160720

DREB
Drebrin

1

1

High-throughput

0.536

High

1390850

MYO19
Unconventional myosin-XIX

1

6

High-throughput

0.536

High

1390851

LZTS2
Leucine zipper putative tumor suppressor 2

1

18

High-throughput

0.536

High

1390853

ANLN
Anillin

1

3

High-throughput

0.536

High

1390856

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

331229

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

337606

FMNL1
Formin-like protein 1

1

1

Small-scale

0.479

High

639796

TAF1
Transcription initiation factor TFIID subunit 1

1

2

High-throughput

0.479

High

1113978

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1227242

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1390857

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

623483

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

869946

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

1385821

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1199641

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

1258539

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.445

High

942820

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

1390854

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025