Protein: SI1L3
Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)

Gene: SI1L3, SIPA1L3
Organism: Homo sapiens
Interactions: 110
UniProt ID: O60292

Gene Ontology (top 5):
GO:0001654 - eye development
GO:0001725 - stress fiber
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0003382 - epithelial cell morphogenesis
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

244562

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

244565

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.712

High

244538

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.709

High

244536

1433T
14-3-3 protein theta

5

20

Small-scale

0.703

High

208600

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

11

High-throughput

0.691

High

244560

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

12

High-throughput

0.691

High

244596

MY18A
Unconventional myosin-XVIIIa

1

3

High-throughput

0.691

High

244600

SIPA1
Signal-induced proliferation-associated protein 1

1

9

High-throughput

0.691

High

244612

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

10

High-throughput

0.691

High

244561

1433E
14-3-3 protein epsilon

3

13

High-throughput

0.667

High

244604

LZTS2
Leucine zipper putative tumor suppressor 2

3

20

High-throughput

0.667

High

244559

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

244569

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

244556

AFAD
Afadin

1

20

High-throughput

0.618

High

244563

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

244571

ZO1
Tight junction protein 1

1

15

High-throughput

0.618

High

244595

PARD3
Partitioning defective 3 homolog

1

19

High-throughput

0.618

High

244608

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

244613

ZO2
Tight junction protein 2

1

12

High-throughput

0.618

High

244605

WDR83
WD repeat domain-containing protein 83

3

7

High-throughput

0.609

High

244539

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

244583

CP135
Centrosomal protein of 135 kDa

3

5

High-throughput

0.599

High

167543

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.586

High

244576

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

High-throughput

0.586

High

244541

CTNB1
Catenin beta-1

2

7

High-throughput

0.584

High

244523

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

123518

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.536

High

244515

LZTS3
Leucine zipper putative tumor suppressor 3

1

19

High-throughput

0.536

High

244521

CHK2
Serine/threonine-protein kinase Chk2

1

2

High-throughput

0.536

High

244534

ITA6
Integrin alpha-6

1

1

High-throughput

0.536

High

244542

MYH9
Myosin-9

1

2

High-throughput

0.536

High

244547

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.536

High

244549

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

244570

CALD1
Caldesmon

1

8

High-throughput

0.536

High

244590

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

244602

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

244607

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

244621

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

14

High-throughput

0.536

High

244620

NINL
Ninein-like protein

2

12

High-throughput

0.533

High

244543

GRIK1
Glutamate receptor ionotropic, kainate 1

1

0

High-throughput

0.518

High

244592

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

244603

SPI2A
Spindlin-2A

1

0

High-throughput

0.513

High

244567

SRPK2
SRSF protein kinase 2

1

8

High-throughput

0.501

High

244548

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.489

High

244516

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

244517

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.479

High

244518

CE152
Centrosomal protein of 152 kDa

1

5

High-throughput

0.479

High

244519

FMNL1
Formin-like protein 1

1

1

Small-scale

0.479

High

244520

LATS1
Serine/threonine-protein kinase LATS1

1

7

High-throughput

0.479

High

244524

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

244525

K1C18
Keratin, type I cytoskeletal 18

1

3

High-throughput

0.479

High

244526

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

244527

VIME
Vimentin

1

12

High-throughput

0.479

High

244529

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

244531

GFAP
Glial fibrillary acidic protein

1

12

High-throughput

0.479

High

244533

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

244535

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

244537

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

244540

CTNA1
Catenin alpha-1

1

4

High-throughput

0.479

High

244544

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

244545

PERI
Peripherin

1

12

High-throughput

0.479

High

244546

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

244550

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

244551

PAXI
Paxillin

1

8

High-throughput

0.479

High

244552

GSK3A
Glycogen synthase kinase-3 alpha

1

12

High-throughput

0.479

High

244553

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.479

High

244554

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

244555

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

244557

ACTB
Actin, cytoplasmic 1

1

7

High-throughput

0.479

High

244558

ARP3
Actin-related protein 3

1

10

High-throughput

0.479

High

244564

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.479

High

244566

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.479

High

244568

VIGLN
Vigilin

1

4

High-throughput

0.479

High

244572

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

244573

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.479

High

244574

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

244575

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

244577

STIL
SCL-interrupting locus protein

1

2

High-throughput

0.479

High

244578

ZYX
Zyxin

1

7

High-throughput

0.479

High

244579

OCLN
Occludin

1

5

High-throughput

0.479

High

244580

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

244581

AMOT
Angiomotin

1

7

High-throughput

0.479

High

244584

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

244585

FTM
Protein fantom

1

12

High-throughput

0.479

High

244586

SAS6
Spindle assembly abnormal protein 6 homolog

1

6

High-throughput

0.479

High

244587

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

244589

HOOK3
Protein Hook homolog 3

1

10

High-throughput

0.479

High

244591

NIN
Ninein

1

11

High-throughput

0.479

High

244593

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

244594

BICD2
Protein bicaudal D homolog 2

1

10

High-throughput

0.479

High

244597

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

244601

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

244609

ANLN
Anillin

1

5

High-throughput

0.479

High

244610

LATS2
Serine/threonine-protein kinase LATS2

1

10

High-throughput

0.479

High

244614

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

244615

XPO7
Exportin-7

1

2

High-throughput

0.479

High

244616

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.479

High

244617

ANC2
Anaphase-promoting complex subunit 2

1

11

High-throughput

0.479

High

244618

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

244619

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.479

High

244606

RNF41
E3 ubiquitin-protein ligase NRDP1

1

3

Small-scale

0.470

High

244528

CLCA
Clathrin light chain A

1

0

High-throughput

0.458

High

244611

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

244522

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.445

High

244530

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

244588

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.445

High

244532

ENPL
Endoplasmin

1

5

High-throughput

0.437

High

244582

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.437

High

244598

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

244599

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High


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Last updated: 11Aug2025