HitPredict

Interactor 1: NH114 (G5EEM0)
Nuclear hormone receptor 114
Gene: nhr-114

Interactor 2: H2L0B0 (H2L0B0)
NR LBD domain-containing protein
Gene: nhr-104

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 418 Ce			1 395
+	Ce
		106915 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		G5EEL3_CAEEL (5-363): 1.46e-104: 315: 41.16
+	Ce
		106951 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		NHR49_CAEEL (4-375): 5.28e-92: 287: 19.66
+	Ce
		106935 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		H2KZA1_CAEEL (3-366): 1.04e-86: 276: 19.70
+	Hs
		587112 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RXRA_HUMAN (4-362): 9.32e-107: 323: 19.50
+	Hs
		587136 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RXRG_HUMAN (1-362): 2.5e-104: 317: 18.23
+	Dm
		558425 ECR_DROME (2-416): 2.73e-92: 298: 20.29		7UP1_DROME (5-367): 1.84e-101: 312: 17.91
+	Hs
		368969 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		ESR1_HUMAN (6-393): 1.09e-95: 299: 18.89
+	Hs
		368869 COT1_HUMAN (2-413): 4.92e-100: 306: 18.93		ESR1_HUMAN (6-393): 1.09e-95: 299: 18.89
+	Bt
		836372 COT1_BOVIN (2-413): 1.22e-99: 305: 18.93		ESR1_BOVIN (6-393): 3.84e-96: 300: 18.16
+	Hs
		500354 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RARB_HUMAN (3-380): 2.86e-96: 296: 17.22
+	Ce
		785440 NHR10_CAEEL (2-411): 1.62e-108: 326: 55.23		NHR10_CAEEL (4-366): 1.53e-86: 269: 22.67
+	Hs
		490049 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		NR2F6_HUMAN (6-367): 1.68e-92: 285: 20.60
+	Mm
		509288 RXRA_MOUSE (3-409): 1.65e-101: 311: 22.30		RARA_MOUSE (3-364): 8.43e-89: 277: 17.68
+	Hs
		487899 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RARA_HUMAN (3-364): 1e-88: 277: 17.40
+	Hs
		530782 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RARG_HUMAN (3-386): 1.66e-88: 276: 16.75
+	Ce
		220326 NHR19_CAEEL (2-409): 5.89e-95: 294: 23.81		NHR49_CAEEL (4-375): 5.28e-92: 287: 19.66
+	Hs
		587117 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		NR4A1_HUMAN (6-361): 1.31e-85: 273: 18.38
+	Ce
		106987 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		Q8MXK0_CAEEL (6-82): 3.21e-18: 87.8: 47.44
+	Ce
		106933 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		NH114_CAEEL (2-107): 4e-18: 87.4: 38.02