Protein: BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)

Gene: BIG3, ARFGEF3
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q5TH69

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0030658 - transport vesicle membrane
GO:0032012 - regulation of ARF protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1216523

PHB2
Prohibitin-2

4

2

Small-scale

0.626

High

1216529

PACC1
Proton-activated chloride channel

3

1

High-throughput

0.604

High

587348

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

1

High-throughput

0.574

High

732997

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

2

High-throughput

0.574

High

879792

NPY2R
Neuropeptide Y receptor type 2

2

3

High-throughput

0.574

High

1216517

SIGL1
SIGLEC family-like protein 1

2

2

High-throughput

0.574

High

1216524

LPAR4
Lysophosphatidic acid receptor 4

2

10

High-throughput

0.574

High

1216537

CLC2D
C-type lectin domain family 2 member D

2

5

High-throughput

0.574

High

1216515

PNKD
Probable thioesterase PNKD

2

1

High-throughput

0.558

High

975080

ARF6
ADP-ribosylation factor 6

1

16

High-throughput

0.553

High

1216533

ARL8B
ADP-ribosylation factor-like protein 8B

1

20

High-throughput

0.553

High

1101509

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

11

High-throughput

0.549

High

967794

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

2

Small-scale

0.543

High

901861

RAB9A
Ras-related protein Rab-9A

2

19

High-throughput

0.533

High

605713

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.512

High

133261

P2Y10
Putative P2Y purinoceptor 10

1

14

High-throughput

0.489

High

182571

GP182
G-protein coupled receptor 182

1

14

High-throughput

0.489

High

638438

FPR1
fMet-Leu-Phe receptor

1

9

High-throughput

0.489

High

683254

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

High-throughput

0.489

High

711556

NK3R
Neuromedin-K receptor

1

3

High-throughput

0.489

High

1216518

ARRD4
Arrestin domain-containing protein 4

1

13

High-throughput

0.489

High

1216526

KLK15
Kallikrein-15

1

4

High-throughput

0.489

High

1216542

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.489

High

1216543

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.489

High

1216544

NPTN
Neuroplastin

1

9

High-throughput

0.489

High

1216513

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1006466

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.457

High

106087

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

189619

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

286216

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.437

High

324146

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.437

High

363402

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.437

High

465544

IGF1R
Insulin-like growth factor 1 receptor

1

7

Small-scale

0.437

High

562114

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.437

High

601323

RHOQ
Rho-related GTP-binding protein RhoQ

1

15

High-throughput

0.437

High

603291

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.437

High

631274

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.437

High

695669

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

765609

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.437

High

891193

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.437

High

891607

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.437

High

896552

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.437

High

900859

RAB5C
Ras-related protein Rab-5C

1

9

High-throughput

0.437

High

901296

RAB7A
Ras-related protein Rab-7a

1

16

High-throughput

0.437

High

955274

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.437

High

956335

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.437

High

1015510

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.437

High

1049392

1433F
14-3-3 protein eta

1

20

High-throughput

0.437

High

1096713

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.437

High

1107811

SQSTM
Sequestosome-1

1

2

High-throughput

0.437

High

1113339

CUL3
Cullin-3

1

4

High-throughput

0.437

High

1144948

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.437

High

1216506

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

1216507

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.437

High

1216510

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

1216512

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1216516

NIN
Ninein

1

3

High-throughput

0.437

High

1216519

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1216520

GOGA1
Golgin subfamily A member 1

1

4

High-throughput

0.437

High

1216522

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.437

High

1216525

VP33B
Vacuolar protein sorting-associated protein 33B

1

4

High-throughput

0.437

High

1216527

RHOJ
Rho-related GTP-binding protein RhoJ

1

15

High-throughput

0.437

High

1216528

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1216530

SACA1
Sperm acrosome membrane-associated protein 1

1

2

High-throughput

0.437

High

1216534

ANFY1
Rabankyrin-5

1

4

High-throughput

0.437

High

1216535

ZO2
Tight junction protein 2

1

7

High-throughput

0.437

High

1216536

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1216540

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.437

High

50576

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.407

High

139230

UPK2
Uroplakin-2

1

3

High-throughput

0.407

High

166316

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

7

High-throughput

0.407

High

171476

S27A2
Long-chain fatty acid transport protein 2

1

5

High-throughput

0.407

High

934726

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.407

High

956898

CXCR4
C-X-C chemokine receptor type 4

1

8

High-throughput

0.407

High

1010924

BAT1
b(0,+)-type amino acid transporter 1

1

4

High-throughput

0.407

High

1216508

ZNT6
Zinc transporter 6

1

7

High-throughput

0.407

High

1216511

S27A1
Long-chain fatty acid transport protein 1

1

5

High-throughput

0.407

High

1216514

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.407

High

1216521

S67A1
Solute carrier family 67 member A1

1

2

High-throughput

0.407

High

1216531

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

4

High-throughput

0.407

High

1216532

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

486569

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

553427

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

0

High-throughput

0.279

Low

1216539

AP4E1
AP-4 complex subunit epsilon-1

1

0

High-throughput

0.279

Low

1216541

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.279

Low

341958

CEP43
Centrosomal protein 43

1

0

High-throughput

0.249

Low

377270

PTHY
Parathyroid hormone

1

0

Small-scale

0.249

Low

560420

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.249

Low

1216509

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

946639

S26A5
Prestin

1

0

High-throughput

0.232

Low

1216538

FZD10
Frizzled-10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025