Protein: PSD3
PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3)

Gene: PSD3
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q9NYI0

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0014069 - postsynaptic density
GO:0032012 - regulation of ARF protein signal transduction
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1049838

1433F
14-3-3 protein eta

3

20

High-throughput

0.609

High

990798

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.580

High

1009900

NUCB2
Nucleobindin-2

1

1

High-throughput

0.575

High

1399429

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

7

Small-scale

0.555

High

975280

ARF6
ADP-ribosylation factor 6

1

14

High-throughput

0.553

High

1015142

ARF5
ADP-ribosylation factor 5

1

13

High-throughput

0.514

High

1145702

RCN1
Reticulocalbin-1

1

1

High-throughput

0.514

High

966946

1433G
14-3-3 protein gamma

1

20

High-throughput

0.506

High

691482

1433T
14-3-3 protein theta

1

20

High-throughput

0.489

High

730294

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.489

High

773666

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.489

High

922060

COPA
Coatomer subunit alpha

1

3

High-throughput

0.489

High

972064

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.489

High

1116063

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.489

High

1383876

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.489

High

1407003

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

1340969

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.481

High

710522

EPHA2
Ephrin type-A receptor 2

1

5

High-throughput

0.479

High

988765

RAC1
Ras-related C3 botulinum toxin substrate 1

1

10

High-throughput

0.479

High

1438195

RHOF
Rho-related GTP-binding protein RhoF

1

14

High-throughput

0.479

High

508732

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.457

High

275570

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

329022

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

1446927

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

633396

MX1
Interferon-induced GTP-binding protein Mx1

1

1

Small-scale

0.439

High

791777

SYUA
Alpha-synuclein

1

5

High-throughput

0.439

High

106746

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

181738

CTDSL
CTD small phosphatase-like protein

1

3

High-throughput

0.437

High

299400

FLOT1
Flotillin-1

1

1

High-throughput

0.437

High

327479

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

341156

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.437

High

374241

RASN
GTPase NRas

1

17

High-throughput

0.437

High

376020

RASK
GTPase KRas

1

16

High-throughput

0.437

High

440229

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.437

High

463803

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.437

High

540713

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.437

High

581332

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.437

High

601470

RHOQ
Rho-related GTP-binding protein RhoQ

1

13

High-throughput

0.437

High

604239

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.437

High

613205

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

614738

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

2

High-throughput

0.437

High

648702

FGFR4
Fibroblast growth factor receptor 4

1

5

High-throughput

0.437

High

659062

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

2

High-throughput

0.437

High

827503

MLH1
DNA mismatch repair protein Mlh1

1

3

High-throughput

0.437

High

845830

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.437

High

928717

PMS2
Mismatch repair endonuclease PMS2

1

3

High-throughput

0.437

High

953708

RAC3
Ras-related C3 botulinum toxin substrate 3

1

10

High-throughput

0.437

High

955676

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.437

High

956518

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.437

High

976611

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.437

High

978354

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.437

High

1004218

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.437

High

1015848

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.437

High

1041328

CAV1
Caveolin-1

1

1

High-throughput

0.437

High

1130204

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.437

High

1145136

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.437

High

1156231

ZYX
Zyxin

1

2

High-throughput

0.437

High

1233529

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1255837

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1432984

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.437

High

1433544

RHOJ
Rho-related GTP-binding protein RhoJ

1

13

High-throughput

0.437

High

1439412

E41LA
Band 4.1-like protein 4A

1

7

High-throughput

0.437

High

1452615

XPO7
Exportin-7

1

3

High-throughput

0.437

High

1452616

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.437

High

1452617

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.437

High

1452618

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.437

High

1139404

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

48822

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.407

High

50715

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.407

High

104376

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.407

High

213660

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.407

High

296581

STAM2
Signal transducing adapter molecule 2

1

4

High-throughput

0.407

High

319032

MICA2
[F-actin]-monooxygenase MICAL2

1

2

High-throughput

0.407

High

333235

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.407

High

462682

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.407

High

535602

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.407

High

567101

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.407

High

698051

CALR
Calreticulin

1

1

High-throughput

0.407

High

699198

CALX
Calnexin

1

1

High-throughput

0.407

High

889024

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.407

High

904161

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.407

High

921809

COPB
Coatomer subunit beta

1

2

High-throughput

0.407

High

987244

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

6

High-throughput

0.407

High

1136392

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.407

High

1146650

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.407

High

1147864

DHC24
Delta(24)-sterol reductase

1

1

High-throughput

0.407

High

1152882

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

2

High-throughput

0.407

High

1199282

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.407

High

1248681

LCLT1
Lysocardiolipin acyltransferase 1

1

1

High-throughput

0.407

High

1258596

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1258823

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

1

High-throughput

0.407

High

1316308

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.407

High

1334036

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.407

High

1340111

ATLA2
Atlastin-2

1

2

High-throughput

0.407

High

1358380

SCFD1
Sec1 family domain-containing protein 1

1

3

High-throughput

0.407

High

1360582

ATLA1
Atlastin-1

1

2

High-throughput

0.407

High

1381540

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.407

High

1396058

SCYL1
N-terminal kinase-like protein

1

5

High-throughput

0.407

High

1412697

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.407

High

1419924

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.407

High

1430077

RGAP1
Rac GTPase-activating protein 1

1

3

High-throughput

0.407

High

1432763

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.407

High

1449575

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.407

High

1452613

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.407

High

1452614

COPG2
Coatomer subunit gamma-2

1

4

High-throughput

0.407

High

1452619

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.407

High

1452620

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.407

High

1452622

COPG1
Coatomer subunit gamma-1

1

4

High-throughput

0.407

High

643100

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

715813

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

791036

TALDO
Transaldolase

1

0

High-throughput

0.249

Low

1159873

OCLN
Occludin

1

0

High-throughput

0.249

Low

1279242

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.249

Low

1325402

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.249

Low

1365376

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.249

Low

1381979

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1446480

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.249

Low

60429

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.232

Low

158337

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.232

Low

211867

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.232

Low

215669

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.232

Low

283377

ERLN1
Erlin-1

1

0

High-throughput

0.232

Low

360137

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.232

Low

873336

COPD
Coatomer subunit delta

1

0

High-throughput

0.232

Low

877021

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.232

Low

883160

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

903811

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

964075

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.232

Low

1027214

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

1097068

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.232

Low

1131415

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.232

Low

1139289

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.232

Low

1327985

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.232

Low

1330417

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.232

Low

1337697

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.232

Low

1338231

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

1386221

ASTRA
Protein Aster-A

1

0

High-throughput

0.232

Low

1401887

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

1411999

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

1412159

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.232

Low

1413784

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

1421161

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.232

Low

1432067

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.232

Low

1439740

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1450851

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

1451096

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

1452612

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.232

Low

1452621

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025