HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 0.60 0.667

The method score is based on:

Property Details
Experiments 18334649, 17463226
Identification Methods affinity chromatography technology, pull down, far western blotting, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, solid phase assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0043066 - negative regulation of apoptotic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1308
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024