HitPredict

Interactor 1: F8VWT9 (F8VWT9)
HECT domain E3 ubiquitin protein ligase 4
Gene: HECTD4

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4284 Hs			1 246
+	Hs
		107328 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		107318 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		107323 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		107331 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433F_HUMAN (4-244): 2.72e-107: 311: 75.51
+	Hs
		730391 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433B_HUMAN (1-246): 3.49e-144: 404: 100.00
+	Hs
		990911 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		691575 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		967063 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		1049943 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433F_HUMAN (4-244): 2.72e-107: 311: 75.51
+	Hs
		131896 WWP2_HUMAN (3639-4279): 6.99e-146: 481: 16.52		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		131929 WWP2_HUMAN (3639-4279): 6.99e-146: 481: 16.52		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		131746 WWP2_HUMAN (3639-4279): 6.99e-146: 481: 16.52		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		691419 WWP1_HUMAN (3745-4279): 2.34e-141: 470: 17.98		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		691335 ITCH_HUMAN (3745-4279): 7.92e-141: 467: 18.22		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Mm
		999114 UBE3C_MOUSE (3700-4276): 9.97e-147: 491: 21.21		1433F_MOUSE (4-244): 8.71e-108: 312: 75.51
+	Hs
		966745 ITCH_HUMAN (3745-4279): 7.92e-141: 467: 18.22		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Mm
		97730 E9PXB7_MOUSE (3770-4279): 5.61e-140: 463: 17.97		1433G_MOUSE (3-246): 1.92e-109: 317: 75.40
+	Hs
		131760 WWP2_HUMAN (3639-4279): 6.99e-146: 481: 16.52		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	Hs
		730826 ITCH_HUMAN (3745-4279): 7.92e-141: 467: 18.22		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	Mm
		97726 E9PXB7_MOUSE (3770-4279): 5.61e-140: 463: 17.97		1433S_MOUSE (3-234): 1.39e-97: 286: 68.38