HitPredict

Interactor 1: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	33961781, 32203420, 35271311, 35914814, 37071682, 22558309, unassigned2213
Identification Methods	affinity chromatography technology, two hybrid, cross-linking study, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016197 - endosomal transport
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1721 Hs			1 864
+	Hs
		787920 ITSN1_HUMAN (1-1721): 0: 897: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		1141846 ITSN1_MOUSE (1-1721): 0: 864: 94.54		EP15R_MOUSE (1-862): 1.06e-124: 399: 92.11
+	Cl
		47357 F1PHV6_CANLF (1-1721): 0: 906: 97.21		A0A8I3PJA6_CANLF (1-862): 1.93e-105: 348: 41.45
+	Hs
		1349279 ITSN2_HUMAN (1-1720): 0: 723: 54.73		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Mm
		788010 ITSN1_MOUSE (1-1721): 0: 864: 94.54		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Hs
		61738 A6H8W8_HUMAN (1-1720): 0: 717: 56.45		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		787985 ITSN2_HUMAN (1-1720): 0: 723: 54.73		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		61732 A6H8W8_HUMAN (1-1720): 0: 717: 56.45		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		1078828 ITSN1_HUMAN (1-1721): 0: 897: 100.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1078919 ITSN1_HUMAN (1-1721): 0: 897: 100.00		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		1078872 ITSN1_HUMAN (1-1721): 0: 897: 100.00		REPS2_HUMAN (14-99): 3.33e-12: 72.3: 24.42
+	Rn
		92844 ITSN1_RAT (1-1721): 0: 853: 92.27		E9PSY8_RAT (9-312): 6.07e-16: 84.7: 15.41
+	Hs
		1349275 ITSN2_HUMAN (1-1720): 0: 723: 54.73		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		506537 BCR_HUMAN (732-1682): 1.5e-71: 266: 12.45		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		788002 EPS15_MOUSE (14-484): 1.37e-37: 156: 16.77		EP15R_MOUSE (1-862): 1.06e-124: 399: 92.11
+	Mm
		787998 EPS15_MOUSE (14-484): 1.37e-37: 156: 16.77		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Hs
		1078876 PREX1_HUMAN (1195-1621): 7.91e-70: 262: 19.10		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		222475 KALRN_RAT (132-1630): 1.93e-75: 281: 11.63		MRCKA_RAT (415-784): 1.14e-21: 103: 9.45
+	Hs
		279897 TRIO_HUMAN (154-1590): 1.54e-71: 269: 10.81		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86