Protein: RL1
Large ribosomal subunit protein uL1 (50S ribosomal protein L1)

Gene: RL1, rplA
Organism: Escherichia coli K-12
Interactions: 165
UniProt ID: P0A7L0

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000049 - tRNA binding
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

492687

RHLB
ATP-dependent RNA helicase RhlB

2

4

High-throughput

0.759

High

492750

SRMB
ATP-dependent RNA helicase SrmB

2

5

High-throughput

0.759

High

492760

RECG
ATP-dependent DNA helicase RecG

1

1

High-throughput

0.691

High

492761

RHLE
ATP-dependent RNA helicase RhlE

1

2

High-throughput

0.691

High

492694

CSPE
Cold shock-like protein CspE

3

15

High-throughput

0.662

High

492702

CSPC
Cold shock-like protein CspC

3

15

High-throughput

0.657

High

492795

RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase

3

1

High-throughput

0.657

High

492695

CSPG
Cold shock-like protein CspG

2

15

High-throughput

0.628

High

492699

DEAD
ATP-dependent RNA helicase DeaD

1

2

High-throughput

0.625

High

492706

YBCJ
Putative RNA-binding protein YbcJ

3

0

High-throughput

0.616

High

492701

CSPA
Cold shock protein CspA

2

15

High-throughput

0.612

High

492704

RLUC
Ribosomal large subunit pseudouridine synthase C

2

3

High-throughput

0.612

High

492688

SYT
Threonine--tRNA ligase

2

2

High-throughput

0.611

High

492753

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

2

2

High-throughput

0.611

High

492751

RNE
Ribonuclease E

3

0

Small-scale

0.607

High

395103

DPO3E
DNA polymerase III subunit epsilon

2

2

High-throughput

0.601

High

492806

SUFC
Probable ATP-dependent transporter SufC

1

0

High-throughput

0.593

High

365805

RPOD
RNA polymerase sigma factor RpoD

2

1

High-throughput

0.588

High

421093

PNP
Polyribonucleotide nucleotidyltransferase

2

7

High-throughput

0.588

High

492700

ULAR
HTH-type transcriptional regulator UlaR

2

1

High-throughput

0.588

High

492739

SRP54
Signal recognition particle protein

2

2

High-throughput

0.588

High

492742

RLME
Ribosomal RNA large subunit methyltransferase E

2

3

High-throughput

0.588

High

492745

SELB
Selenocysteine-specific elongation factor

2

3

High-throughput

0.588

High

492747

ICLR
Transcriptional repressor IclR

2

1

High-throughput

0.588

High

492749

RNR
Ribonuclease R

2

3

High-throughput

0.588

High

492768

AIDB
Putative acyl-CoA dehydrogenase AidB

2

2

High-throughput

0.588

High

492770

CBPA
Curved DNA-binding protein

2

2

High-throughput

0.588

High

492788

RL4
Large ribosomal subunit protein uL4

2

2

High-throughput

0.588

High

492712

DNAB
Replicative DNA helicase DnaB

2

0

High-throughput

0.585

High

492772

RLMN
Dual-specificity RNA methyltransferase RlmN

2

0

High-throughput

0.585

High

492796

RLMI
Ribosomal RNA large subunit methyltransferase I

2

1

High-throughput

0.584

High

492776

DPPF
Dipeptide transport ATP-binding protein DppF

1

0

High-throughput

0.578

High

492686

UVRC
UvrABC system protein C

2

0

High-throughput

0.576

High

492724

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.576

High

492743

DPO3A
DNA polymerase III subunit alpha

2

0

High-throughput

0.576

High

492804

DCYD
D-cysteine desulfhydrase

2

0

High-throughput

0.576

High

361738

PHSM
Maltodextrin phosphorylase

2

0

High-throughput

0.563

High

490625

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

2

0

High-throughput

0.563

High

491525

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

2

0

High-throughput

0.563

High

492217

PYRH
Uridylate kinase

2

0

High-throughput

0.563

High

492721

YIBL
Uncharacterized protein YibL

2

0

High-throughput

0.563

High

492771

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

1

High-throughput

0.553

High

492784

HRPA
ATP-dependent RNA helicase HrpA

1

3

High-throughput

0.553

High

492727

DCM
DNA-cytosine methyltransferase

2

1

High-throughput

0.549

High

492762

HOLB
DNA polymerase III subunit delta'

2

1

High-throughput

0.537

High

382639

RS7
Small ribosomal subunit protein uS7

1

2

High-throughput

0.536

High

492416

RL11
Large ribosomal subunit protein uL11

1

2

High-throughput

0.536

High

492676

RS12
Small ribosomal subunit protein uS12

1

1

High-throughput

0.536

High

492678

RS19
Small ribosomal subunit protein uS19

1

2

High-throughput

0.536

High

492680

RS5
Small ribosomal subunit protein uS5

1

2

High-throughput

0.536

High

492696

CSPI
Cold shock-like protein CspI

1

15

High-throughput

0.536

High

492714

DBHB
DNA-binding protein HU-beta

1

2

High-throughput

0.536

High

492723

RL16
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

492732

PARC
DNA topoisomerase 4 subunit A

1

1

High-throughput

0.536

High

492736

RL17
Large ribosomal subunit protein bL17

1

3

High-throughput

0.536

High

492738

RS1
Small ribosomal subunit protein bS1

1

6

High-throughput

0.536

High

492741

TRML
tRNA

1

3

High-throughput

0.536

High

492773

CSPB
Cold shock-like protein CspB

1

15

High-throughput

0.536

High

492783

ARFB
Peptidyl-tRNA hydrolase ArfB

1

2

High-throughput

0.536

High

408519

3MG2
DNA-3-methyladenine glycosylase 2

1

0

High-throughput

0.513

High

492677

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.513

High

492679

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

492683

SSRP
SsrA-binding protein

1

0

High-throughput

0.513

High

492690

MATP
Macrodomain Ter protein

1

0

High-throughput

0.513

High

492703

GLNB
Nitrogen regulatory protein P-II 1

1

0

High-throughput

0.513

High

492705

YBAK
Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK

1

0

High-throughput

0.513

High

492707

COABC
Coenzyme A biosynthesis bifunctional protein CoaBC

1

0

High-throughput

0.513

High

492708

DNAG
DNA primase

1

0

High-throughput

0.513

High

492713

GLMU
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase

1

0

High-throughput

0.513

High

492715

HSLR
Heat shock protein 15

1

0

High-throughput

0.513

High

492725

RS15
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

492737

RS14
Small ribosomal subunit protein uS14

1

0

High-throughput

0.513

High

492755

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

0

High-throughput

0.513

High

492757

HEMH
Ferrochelatase

1

0

High-throughput

0.513

High

492758

FMT
Methionyl-tRNA formyltransferase

1

0

High-throughput

0.513

High

492778

WAAF
Lipopolysaccharide heptosyltransferase 2

1

0

High-throughput

0.513

High

492787

TILS
tRNA(Ile)-lysidine synthase

1

0

High-throughput

0.513

High

492809

THII
tRNA sulfurtransferase

1

0

High-throughput

0.513

High

492675

RL9
Large ribosomal subunit protein bL9

1

1

Small-scale

0.501

High

492764

PQQL
Probable zinc protease PqqL

1

3

High-throughput

0.500

High

469357

YCIH
Uncharacterized protein YciH

1

1

High-throughput

0.489

High

492752

PDEL
Cyclic di-GMP phosphodiesterase PdeL

1

1

High-throughput

0.489

High

492765

RLUF
Dual-specificity RNA pseudouridine synthase RluF

1

1

High-throughput

0.489

High

473249

DNAJ
Chaperone protein DnaJ

1

2

High-throughput

0.484

High

490472

HSCB
Co-chaperone protein HscB

1

1

High-throughput

0.484

High

490918

IHFA
Integration host factor subunit alpha

1

2

High-throughput

0.484

High

490948

IHFB
Integration host factor subunit beta

1

2

High-throughput

0.484

High

492682

RPOA
DNA-directed RNA polymerase subunit alpha

1

1

High-throughput

0.484

High

492684

TGT
Queuine tRNA-ribosyltransferase

1

1

High-throughput

0.484

High

492693

CSPD
Cold shock-like protein CspD

1

15

High-throughput

0.484

High

492716

ALLR
HTH-type transcriptional repressor AllR

1

1

High-throughput

0.484

High

492740

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

3

High-throughput

0.484

High

492744

RPOS
RNA polymerase sigma factor RpoS

1

1

High-throughput

0.484

High

492780

RLUB
Ribosomal large subunit pseudouridine synthase B

1

3

High-throughput

0.484

High

492759

MAK
Fructokinase

1

0

High-throughput

0.479

High

492786

YHHX
Uncharacterized oxidoreductase YhhX

1

0

High-throughput

0.479

High

492790

YQJI
Transcriptional regulator YqjI

1

0

High-throughput

0.479

High

492748

PARE
DNA topoisomerase 4 subunit B

1

1

High-throughput

0.479

High

490237

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

490660

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

490851

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

491913

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.464

High

492681

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.464

High

492697

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

492709

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.464

High

492730

NUSA
Transcription termination/antitermination protein NusA

1

0

High-throughput

0.464

High

432114

APAH
Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]

1

0

High-throughput

0.458

High

483691

PUTA
Bifunctional protein PutA [Includes: Proline dehydrogenase

1

0

High-throughput

0.458

High

492175

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.458

High

492689

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

492691

DARP
Dual-action ribosomal maturation protein DarP

1

0

High-throughput

0.458

High

492698

LON
Lon protease

1

0

High-throughput

0.458

High

492710

KDSC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC

1

0

High-throughput

0.458

High

492720

KPYK1
Pyruvate kinase I

1

0

High-throughput

0.458

High

492729

NSRR
HTH-type transcriptional repressor NsrR

1

0

High-throughput

0.458

High

492734

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

492735

SPOT
Bifunctional

1

0

High-throughput

0.458

High

492754

ISPA
Farnesyl diphosphate synthase

1

0

High-throughput

0.458

High

492769

TKT2
Transketolase 2

1

0

High-throughput

0.458

High

492789

GMHBB
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

1

0

High-throughput

0.458

High

492791

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

492810

MENI
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1

0

High-throughput

0.458

High

492767

PDEC
Probable cyclic di-GMP phosphodiesterase PdeC

1

1

High-throughput

0.457

High

492746

SRLR
Glucitol operon repressor

1

1

High-throughput

0.442

High

492812

UACF
Putative oxidoreductase UacF

1

2

High-throughput

0.437

High

492685

TIG
Trigger factor

1

0

Small-scale

0.426

High

492813

YAJL
Protein/nucleic acid deglycase 3

1

0

Small-scale

0.426

High

492803

YEAO
Uncharacterized protein YeaO

2

0

High-throughput

0.318

High

492733

ATL
DNA base-flipping protein

2

0

High-throughput

0.307

High

492794

YBJX
Uncharacterized protein YbjX

2

0

High-throughput

0.307

High

492798

RLHA
23S rRNA 5-hydroxycytidine C2501 synthase

2

0

High-throughput

0.307

High

445394

DPO3X
DNA polymerase III subunit tau

1

0

High-throughput

0.279

Low

450106

PRIB
Replication restart protein PriB

1

0

High-throughput

0.279

Low

491779

MOAC
Cyclic pyranopterin monophosphate synthase

1

0

High-throughput

0.279

Low

492717

RUTR
HTH-type transcriptional regulator RutR

1

0

High-throughput

0.279

Low

492719

YDIE
Uncharacterized protein YdiE

1

0

High-throughput

0.279

Low

492728

DMA
DNA adenine methylase

1

0

High-throughput

0.279

Low

492756

PRIC
Replication restart protein PriC

1

0

High-throughput

0.279

Low

492763

RIBX
N-glycosidase YbiA

1

0

High-throughput

0.279

Low

492774

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

492785

YHBQ
UPF0213 protein YhbQ

1

0

High-throughput

0.279

Low

492792

WCAK
Colanic acid biosynthesis protein WcaK

1

0

High-throughput

0.279

Low

492793

RLMC
23S rRNA

1

0

High-throughput

0.279

Low

492797

YMGA
Probable two-component-system connector protein YmgA

1

0

High-throughput

0.279

Low

492800

YNEG
Uncharacterized protein YneG

1

0

High-throughput

0.279

Low

492802

NIMR
HTH-type transcriptional regulator NimR

1

0

High-throughput

0.279

Low

492805

YGAV
HTH-type transcriptional regulator YgaV

1

0

High-throughput

0.279

Low

492807

YDHQ
Protein YdhQ

1

0

High-throughput

0.279

Low

492811

MAA
Maltose O-acetyltransferase

1

0

High-throughput

0.279

Low

492718

LAPA
Lipopolysaccharide assembly protein A

1

0

High-throughput

0.261

Low

492722

YGGE
Uncharacterized protein YggE

1

0

High-throughput

0.261

Low

492711

KDTA
3-deoxy-D-manno-octulosonic acid transferase

1

0

High-throughput

0.253

Low

492775

DCTR
HTH-type transcriptional regulator DctR

1

0

High-throughput

0.253

Low

393852

PBPA
Penicillin-binding protein 1A

1

0

High-throughput

0.249

Low

492692

BLC
Outer membrane lipoprotein Blc

1

0

High-throughput

0.249

Low

492726

PAEA
Polyamine export protein

1

0

High-throughput

0.249

Low

492731

OPPB
Oligopeptide transport system permease protein OppB

1

0

High-throughput

0.249

Low

492766

YJBH
Uncharacterized lipoprotein YjbH

1

0

High-throughput

0.249

Low

492777

YHJG
AsmA family protein YhjG

1

0

High-throughput

0.249

Low

492779

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

492781

YJIE
HTH-type transcriptional regulator YjiE

1

0

High-throughput

0.249

Low

492782

YJJU
Uncharacterized protein YjjU

1

0

High-throughput

0.249

Low

492799

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.249

Low

492801

YNHG
Probable L,D-transpeptidase YnhG

1

0

High-throughput

0.249

Low

492808

YBAY
Uncharacterized lipoprotein YbaY

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025