HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	16949367, 25499913, 30166453, 31155351, 33854235, 33854239, 35271311, 37689310, 20562859
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 1298
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (5-294): 1.05e-85: 284: 17.38
+	Mm
		1112258 DDB1_MOUSE (1-1140): 0: 1422: 99.65		DCAF5_MOUSE (13-787): 2.25e-79: 284: 14.78
+	Hs
		1082337 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DCAF5_HUMAN (13-774): 2.83e-71: 260: 14.74
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75
+	Hs
		245605 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1X_HUMAN (28-159): 4.53e-15: 82.1: 20.14
+	Hs
		1082480 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WSB1_HUMAN (57-256): 4.52e-15: 81.3: 13.51
+	Hs
		1082374 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1R_HUMAN (28-201): 1.6e-14: 80.1: 17.98
+	Hs
		1082427 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WSB2_HUMAN (41-201): 1.66e-13: 75.9: 23.67
+	At
		95049 DDB1A_ARATH (2-1140): 0: 1255: 52.09		KTN82_ARATH (126-797): 3.69e-37: 154: 11.79
+	At
		95047 DDB1B_ARATH (3-1140): 0: 1248: 50.92		KTN82_ARATH (126-797): 3.69e-37: 154: 11.79
+	Hs
		267761 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		TAF5L_HUMAN (57-304): 3.13e-36: 148: 15.14
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58
+	Sc
		744701 CFT1_YEAST (11-1125): 0: 678: 14.79		TAF5_YEAST (9-127): 1.2e-32: 139: 22.22
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (57-314): 6.17e-40: 162: 14.14