HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: DDX23 (Q9BUQ8)
Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
Gene: DDX23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 820
+	Hs
		1084557 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DDX17_HUMAN (337-820): 5.87e-132: 412: 34.97
+	Hs
		571475 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DDX5_HUMAN (297-801): 3.08e-129: 401: 32.81
+	Hs
		571365 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		DDX5_HUMAN (297-801): 3.08e-129: 401: 32.81
+	Hs
		1084656 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DDX41_HUMAN (365-795): 7.12e-81: 273: 39.32
+	Hs
		134018 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		DDX3X_HUMAN (236-804): 2.78e-130: 405: 30.65
+	Hs
		133858 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		DDX3X_HUMAN (236-804): 2.78e-130: 405: 30.65
+	Mm
		1111932 SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30		DDX5_MOUSE (290-801): 5.71e-131: 405: 32.36
+	Sc
		376580 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		DED1_YEAST (348-797): 3.22e-126: 393: 33.55