Protein: HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (HMG-CoA reductase 1) (EC 1.1.1.34)

Gene: HMDH1, HMG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P12683

Gene Ontology (top 5):
GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005635 - nuclear envelope
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554300

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

4

2

High-throughput

0.882

High

554344

NSG1
Protein NSG1

2

1

High-throughput

0.793

High

554299

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

2

2

High-throughput

0.743

High

554329

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

554339

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.614

High

554352

ELO3
Fatty acid elongase 3

2

1

High-throughput

0.614

High

554353

SNL1
HSP70 co-chaperone SNL1

2

0

High-throughput

0.588

High

554337

NU170
Nucleoporin NUP170

2

1

High-throughput

0.584

High

554335

SRPB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.541

High

554382

YP264
Probable transport protein YPL264C

1

1

High-throughput

0.541

High

554376

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

1

Small-scale

0.536

High

554379

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

4

Small-scale

0.536

High

455620

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

1

0

High-throughput

0.518

High

554320

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.518

High

554340

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.518

High

554366

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.518

High

554369

TNA1
High-affinity nicotinic acid transporter

1

0

High-throughput

0.518

High

554367

VPS73
Vacuolar protein sorting-associated protein 73

1

1

High-throughput

0.494

High

554345

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

438597

SC160
Protein SCP160

1

1

High-throughput

0.479

High

554306

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.479

High

554307

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

554311

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

High-throughput

0.479

High

554313

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

554314

CWH43
Protein CWH43

1

1

High-throughput

0.479

High

554319

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

554321

ERG24
Delta(14)-sterol reductase ERG24

1

2

High-throughput

0.479

High

554324

EMP24
Endosomal protein P24B

1

1

High-throughput

0.479

High

554328

SEC66
Translocation protein SEC66

1

1

High-throughput

0.479

High

554330

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

554333

YET1
Endoplasmic reticulum transmembrane protein 1

1

3

High-throughput

0.479

High

554336

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

High-throughput

0.479

High

554347

PO152
Nucleoporin POM152

1

1

High-throughput

0.479

High

554348

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.479

High

554351

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.479

High

554357

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.479

High

554359

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

554361

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

554365

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

554370

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

1

High-throughput

0.479

High

554371

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

554372

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

1

High-throughput

0.479

High

554377

YET3
Endoplasmic reticulum transmembrane protein 3

1

3

High-throughput

0.479

High

554387

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

1

High-throughput

0.479

High

554302

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.458

High

554327

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.458

High

554331

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.458

High

554341

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.458

High

554346

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

554354

LCB2
Serine palmitoyltransferase 2

1

0

High-throughput

0.458

High

554358

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.458

High

554362

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

554363

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.458

High

554368

ERV14
ER-derived vesicles protein ERV14

1

0

High-throughput

0.458

High

554374

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

554375

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

509362

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.457

High

485995

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

452796

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

554303

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

554310

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

554315

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

554332

YKK0
Probable intramembrane protease YKL100C

1

1

High-throughput

0.437

High

554373

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

554383

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

554343

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.426

High

554360

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

High-throughput

0.426

High

554364

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.426

High

358100

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.407

High

394165

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

525764

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

543620

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

554304

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

554318

XPO1
Exportin-1

1

1

High-throughput

0.407

High

554326

PRS7
26S proteasome regulatory subunit 7 homolog

1

3

High-throughput

0.407

High

554338

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.407

High

554350

IMB4
Importin subunit beta-4

1

1

High-throughput

0.407

High

554355

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

554356

GCN20
Protein GCN20

1

1

High-throughput

0.407

High

554323

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.282

High

554378

SPO75
Sporulation-specific protein 75

1

0

High-throughput

0.282

High

554312

RAD51
DNA repair protein RAD51

1

0

High-throughput

0.279

Low

382812

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

503741

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

510129

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.249

Low

554301

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

554308

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

554316

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

554317

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

554322

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

554325

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

554334

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

554381

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

554386

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.249

Low

386539

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

531220

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.232

Low

554305

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.232

Low

554309

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

554342

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

554349

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.232

Low

554380

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.232

Low

554384

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low

554385

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025