HitPredict

Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Interactor 2: EGLN1 (Q9GZT9)
Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)
Gene: EGLN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 25361009, 26611735, 27563096, 16155211, 24681946, 17069766, 18063574, 29279301, 31763849, 19604478, 17353276, 23413029, 25974097, 22946054, 17442832, 33550096, 34007068, 34841716, 35169254, 36400971 and 8 others

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Identification Methods affinity chromatography technology, enzymatic study, two hybrid, pull down, x-ray crystallography, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, experimental interaction detection, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association, enzymatic reaction, hydroxylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains 2OG-FeII_Oxy_3~HIF-1
Common GO terms GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006879 - intracellular iron ion homeostasis
and 4 others

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Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 826
Hs

1 426
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Last updated: 15 Jul 2024