Protein: GEMI5
Gem-associated protein 5 (Gemin5)

Gene: GEMI5, GEMIN5
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q8TEQ6

Gene Ontology (top 5):
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003730 - mRNA 3'-UTR binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1353062

DDX20
Probable ATP-dependent RNA helicase DDX20

8

11

Small-scale

0.970

High

1353069

STRAP
Serine-threonine kinase receptor-associated protein

3

20

High-throughput

0.871

High

1099738

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

4

High-throughput

0.776

High

1160524

SMN
Survival motor neuron protein

6

1

Small-scale

0.739

High

973990

RUXF
Small nuclear ribonucleoprotein F

5

6

Small-scale

0.718

High

472917

RU17
U1 small nuclear ribonucleoprotein 70 kDa

5

6

High-throughput

0.716

High

973773

RUXE
Small nuclear ribonucleoprotein E

4

1

Small-scale

0.700

High

1353056

GAR1
H/ACA ribonucleoprotein complex subunit 1

4

1

High-throughput

0.699

High

141582

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

High-throughput

0.691

High

969995

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.691

High

1232702

H2A2A
Histone H2A type 2-A

1

7

High-throughput

0.691

High

1353045

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

5

High-throughput

0.691

High

1353051

DDX21
Nucleolar RNA helicase 2

1

8

High-throughput

0.691

High

485693

RU2A
U2 small nuclear ribonucleoprotein A'

4

4

High-throughput

0.691

High

974795

SMD3
Small nuclear ribonucleoprotein Sm D3

3

7

Small-scale

0.674

High

974619

SMD2
Small nuclear ribonucleoprotein Sm D2

3

2

Small-scale

0.670

High

471889

RU2B
U2 small nuclear ribonucleoprotein B''

3

7

High-throughput

0.662

High

574385

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

3

3

Small-scale

0.662

High

974166

RUXG
Small nuclear ribonucleoprotein G

3

6

Small-scale

0.660

High

869067

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.656

High

908342

AK1D1
Aldo-keto reductase family 1 member D1

3

0

High-throughput

0.638

High

944527

GEMI4
Gem-associated protein 4

3

0

Small-scale

0.638

High

1291638

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.638

High

239152

ZNRD2
Protein ZNRD2

2

2

High-throughput

0.628

High

991214

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

4

High-throughput

0.628

High

167108

GEMI2
Gem-associated protein 2

3

0

Small-scale

0.628

High

974428

SMD1
Small nuclear ribonucleoprotein Sm D1

2

7

Small-scale

0.624

High

1142112

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.618

High

247392

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

5

High-throughput

0.618

High

355566

NSD2
Histone-lysine N-methyltransferase NSD2

1

7

Small-scale

0.618

High

883290

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

9

High-throughput

0.618

High

970825

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.618

High

1094591

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.618

High

1131082

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

Small-scale

0.618

High

1138427

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.618

High

1227133

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.618

High

1241705

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.618

High

1254783

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1289478

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.618

High

1353030

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

10

Small-scale

0.618

High

1353044

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1353050

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.618

High

1353063

FBW1B
F-box/WD repeat-containing protein 11

1

18

High-throughput

0.618

High

1353065

INO80
Chromatin-remodeling ATPase INO80

1

9

High-throughput

0.618

High

775218

FUS
RNA-binding protein FUS

2

7

High-throughput

0.611

High

1113809

CUL3
Cullin-3

2

20

High-throughput

0.611

High

1333037

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

1353047

GEMI7
Gem-associated protein 7

2

0

High-throughput

0.602

High

1353055

GEMI8
Gem-associated protein 8

2

0

High-throughput

0.602

High

194281

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.586

High

1353020

GEMI6
Gem-associated protein 6

2

0

Small-scale

0.585

High

589240

RFA2
Replication protein A 32 kDa subunit

2

8

High-throughput

0.584

High

696025

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

7

High-throughput

0.584

High

768723

RFA3
Replication protein A 14 kDa subunit

2

7

High-throughput

0.584

High

853717

MK08
Mitogen-activated protein kinase 8

1

7

Small-scale

0.578

High

853898

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

11

Small-scale

0.578

High

1353038

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

6

Small-scale

0.578

High

1234876

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

396578

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

436706

KPCB
Protein kinase C beta type

2

7

High-throughput

0.571

High

1327769

SH2D3
SH2 domain-containing protein 3C

2

4

High-throughput

0.571

High

1353040

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.553

High

1353024

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.546

High

445582

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.536

High

259008

DNJA2
DnaJ homolog subfamily A member 2

1

15

High-throughput

0.536

High

325945

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

High-throughput

0.536

High

445225

S10A6
Protein S100-A6

1

2

High-throughput

0.536

High

447251

NPM
Nucleophosmin

1

8

High-throughput

0.536

High

478126

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

High-throughput

0.536

High

480236

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

528309

THIO
Thioredoxin

1

1

High-throughput

0.536

High

542126

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

683293

TNR5
Tumor necrosis factor receptor superfamily member 5

1

3

High-throughput

0.536

High

729367

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

14

High-throughput

0.536

High

755607

TTK
Dual specificity protein kinase TTK

1

6

High-throughput

0.536

High

767475

RADI
Radixin

1

3

High-throughput

0.536

High

881566

CDK8
Cyclin-dependent kinase 8

1

14

High-throughput

0.536

High

926208

ICLN
Methylosome subunit pICln

1

2

High-throughput

0.536

High

976756

ERF1
Eukaryotic peptide chain release factor subunit 1

1

2

High-throughput

0.536

High

1065316

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.536

High

1105640

GOGA4
Golgin subfamily A member 4

1

13

High-throughput

0.536

High

1127030

RBM39
RNA-binding protein 39

1

9

High-throughput

0.536

High

1144097

TEBP
Prostaglandin E synthase 3

1

5

High-throughput

0.536

High

1149140

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.536

High

1151162

OASL
2'-5'-oligoadenylate synthase-like protein

1

10

High-throughput

0.536

High

1160217

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

10

High-throughput

0.536

High

1162107

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

1

High-throughput

0.536

High

1180433

PRIC4
Prickle-like protein 4

1

2

High-throughput

0.536

High

1353019

PDC6I
Programmed cell death 6-interacting protein

1

10

High-throughput

0.536

High

1353021

PSPC1
Paraspeckle component 1

1

15

High-throughput

0.536

High

1353029

FGF14
Fibroblast growth factor 14

1

3

High-throughput

0.536

High

1353031

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1353032

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

1353034

ARMC5
Armadillo repeat-containing protein 5

1

6

High-throughput

0.536

High

1353037

RBM14
RNA-binding protein 14

1

14

High-throughput

0.536

High

1353046

SYNCI
Syncoilin

1

11

High-throughput

0.536

High

1353048

CPAP
Centrosomal P4.1-associated protein

1

9

High-throughput

0.536

High

1353060

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.536

High

764906

CTNB1
Catenin beta-1

1

6

Small-scale

0.515

High

365768

KAD1
Adenylate kinase isoenzyme 1

1

0

High-throughput

0.513

High

691801

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

1013493

LSM11
U7 snRNA-associated Sm-like protein LSm11

1

0

High-throughput

0.513

High

1131017

LPIN1
Phosphatidate phosphatase LPIN1

1

0

High-throughput

0.513

High

1142804

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.513

High

1353058

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.513

High

1353067

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

1353071

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

889472

CLK1
Dual specificity protein kinase CLK1

1

13

High-throughput

0.501

High

964381

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

1179011

S35G1
Solute carrier family 35 member G1

1

3

High-throughput

0.489

High

1353070

NPTN
Neuroplastin

1

3

High-throughput

0.489

High

176078

KDM6B
Lysine-specific demethylase 6B

1

5

Small-scale

0.479

High

231155

AIRE
Autoimmune regulator

1

12

Small-scale

0.479

High

242386

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.479

High

246806

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

260204

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

261843

PFD1
Prefoldin subunit 1

1

4

High-throughput

0.479

High

346103

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

352203

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.479

High

372662

MYC
Myc proto-oncogene protein

1

17

High-throughput

0.479

High

414281

P53
Cellular tumor antigen p53

1

10

High-throughput

0.479

High

543245

UBL4A
Ubiquitin-like protein 4A

1

12

High-throughput

0.479

High

731496

STIP1
Stress-induced-phosphoprotein 1

1

11

High-throughput

0.479

High

765734

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.479

High

785321

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.479

High

799325

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

831113

CCNF
Cyclin-F

1

20

High-throughput

0.479

High

862320

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

879297

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

11

High-throughput

0.479

High

884173

SRP09
Signal recognition particle 9 kDa protein

1

1

Small-scale

0.479

High

954203

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

956172

SRP54
Signal recognition particle subunit SRP54

1

2

Small-scale

0.479

High

1004880

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

1106016

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.479

High

1107048

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

High-throughput

0.479

High

1109929

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1145292

RNPS1
RNA-binding protein with serine-rich domain 1

1

9

High-throughput

0.479

High

1194239

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

1215729

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1229582

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1276529

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1294541

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

9

Small-scale

0.479

High

1295507

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.479

High

1329763

SIR6
NAD-dependent protein deacylase sirtuin-6

1

12

High-throughput

0.479

High

1351909

RBCC1
RB1-inducible coiled-coil protein 1

1

18

High-throughput

0.479

High

1353022

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

1353023

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1353025

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1353026

RBP56
TATA-binding protein-associated factor 2N

1

6

High-throughput

0.479

High

1353027

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

1353028

FGF11
Fibroblast growth factor 11

1

3

High-throughput

0.479

High

1353036

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

1353039

BARD1
BRCA1-associated RING domain protein 1

1

4

High-throughput

0.479

High

1353041

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

1353042

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

1353043

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

1353052

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

12

High-throughput

0.479

High

1353054

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1353057

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1353059

MBD2
Methyl-CpG-binding domain protein 2

1

1

High-throughput

0.479

High

1353061

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1353064

RCOR1
REST corepressor 1

1

12

High-throughput

0.479

High

337603

FMNL1
Formin-like protein 1

1

0

Small-scale

0.458

High

1193546

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

1353033

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1353053

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

71595

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

6

High-throughput

0.445

High

330251

VENTX
Homeobox protein VENTX

1

9

High-throughput

0.445

High

401193

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.445

High

430159

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

437747

HEPS
Serine protease hepsin

1

2

High-throughput

0.445

High

1066724

NCBP1
Nuclear cap-binding protein subunit 1

1

1

High-throughput

0.445

High

1130358

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.445

High

1199619

KLH22
Kelch-like protein 22

1

7

High-throughput

0.445

High

1209432

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1217001

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

7

Small-scale

0.445

High

1353066

AKP8L
A-kinase anchor protein 8-like

1

2

High-throughput

0.445

High

412308

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.437

High

939558

UCP3
Putative mitochondrial transporter UCP3

1

1

Small-scale

0.437

High

1250172

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1353068

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

166360

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

171525

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

95772

E5RGS4
Prefoldin subunit 1

1

4

High-throughput

0.407

High

1353049

CPNE5
Copine-5

2

0

High-throughput

0.328

High

1353035

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1352318

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.249

Low

1085

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1104027

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025