Protein: TBL3
Transducin beta-like protein 3 (WD repeat-containing protein SAZD)

Gene: TBL3
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q12788

Gene Ontology (top 5):
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085682

WDR36
WD repeat-containing protein 36

2

18

High-throughput

0.789

High

1085725

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

2

8

High-throughput

0.789

High

1085730

WDR3
WD repeat-containing protein 3

2

17

High-throughput

0.789

High

838930

RHG25
Rho GTPase-activating protein 25

3

4

High-throughput

0.770

High

1085716

ANLN
Anillin

2

5

High-throughput

0.754

High

969818

RS16
Small ribosomal subunit protein uS9

1

9

High-throughput

0.691

High

1085660

PWP2
Periodic tryptophan protein 2 homolog

1

16

High-throughput

0.691

High

446952

NPM
Nucleophosmin

3

8

High-throughput

0.667

High

1085663

IF16
Gamma-interferon-inducible protein 16

3

11

High-throughput

0.656

High

1085687

APBP2
Amyloid protein-binding protein 2

2

4

High-throughput

0.646

High

686683

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

3

High-throughput

0.628

High

1085703

RBM4
RNA-binding protein 4

2

17

High-throughput

0.628

High

657230

KALM
Anosmin-1

1

1

High-throughput

0.618

High

285239

EED
Polycomb protein EED

1

19

High-throughput

0.618

High

883228

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

18

High-throughput

0.618

High

929922

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

11

High-throughput

0.618

High

979562

H4
Histone H4

1

7

High-throughput

0.618

High

1085649

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

11

High-throughput

0.618

High

1085655

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.618

High

1085662

DDB1
DNA damage-binding protein 1

1

13

Small-scale

0.618

High

1085681

NUP43
Nucleoporin Nup43

1

18

High-throughput

0.618

High

1085692

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

17

High-throughput

0.618

High

1085702

DDA1
DET1- and DDB1-associated protein 1

1

3

High-throughput

0.618

High

1085713

RC3H2
Roquin-2

1

9

High-throughput

0.618

High

1085718

DCA13
DDB1- and CUL4-associated factor 13

1

16

Small-scale

0.618

High

140893

NOP56
Nucleolar protein 56

2

11

High-throughput

0.611

High

290546

SURF6
Surfeit locus protein 6

2

3

High-throughput

0.601

High

1085697

MPH6
M-phase phosphoprotein 6

2

1

High-throughput

0.601

High

907401

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

9

High-throughput

0.590

High

259860

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

345722

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

18

High-throughput

0.584

High

371880

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

643806

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

9

High-throughput

0.584

High

978895

RS6
Small ribosomal subunit protein eS6

2

5

High-throughput

0.584

High

395995

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

777269

AHR
Aryl hydrocarbon receptor

1

5

Small-scale

0.561

High

1085651

CUL4B
Cullin-4B

1

20

Small-scale

0.561

High

457392

TBB5
Tubulin beta chain

2

12

High-throughput

0.558

High

157294

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.553

High

970409

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.553

High

1085673

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

1085678

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.553

High

1085704

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.553

High

1085710

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

208245

RRP8
Ribosomal RNA-processing protein 8

1

5

High-throughput

0.536

High

785122

RL4
Large ribosomal subunit protein uL4

1

8

High-throughput

0.536

High

833098

MNDA
Myeloid cell nuclear differentiation antigen

1

11

High-throughput

0.536

High

854017

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

1027409

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

16

High-throughput

0.536

High

1041744

PPARD
Peroxisome proliferator-activated receptor delta

1

15

High-throughput

0.536

High

1085684

PSPC1
Paraspeckle component 1

1

20

High-throughput

0.536

High

1085698

RBM4B
RNA-binding protein 4B

1

18

High-throughput

0.536

High

1085714

EXOS4
Exosome complex component RRP41

1

13

High-throughput

0.536

High

1085715

EXOS5
Exosome complex component RRP46

1

15

High-throughput

0.536

High

1085729

G3BP2
Ras GTPase-activating protein-binding protein 2

1

12

High-throughput

0.536

High

1085735

EXOS1
Exosome complex component CSL4

1

8

High-throughput

0.536

High

272120

OBSL1
Obscurin-like protein 1

2

5

High-throughput

0.533

High

1085656

CUL7
Cullin-7

2

5

High-throughput

0.533

High

889974

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

730548

1433S
14-3-3 protein sigma

1

18

High-throughput

0.494

High

1085723

ITSN2
Intersectin-2

1

7

High-throughput

0.494

High

191624

MAGB2
Melanoma-associated antigen B2

1

6

High-throughput

0.489

High

258851

DNJA2
DnaJ homolog subfamily A member 2

1

13

High-throughput

0.489

High

295575

CIB2
Calcium and integrin-binding family member 2

1

4

High-throughput

0.489

High

334176

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.489

High

346983

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

1085664

RTN1
Reticulon-1

1

4

High-throughput

0.489

High

1085676

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

1085696

TECTB
Beta-tectorin

1

2

High-throughput

0.489

High

1085701

AFG2B
ATPase family gene 2 protein homolog B

1

13

High-throughput

0.489

High

1085731

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.489

High

1085734

KLH20
Kelch-like protein 20

1

5

High-throughput

0.489

High

129018

MEN1
Menin

1

3

High-throughput

0.479

High

132721

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

9

Small-scale

0.479

High

190889

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

218121

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

222983

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

227521

SPOP
Speckle-type POZ protein

1

10

High-throughput

0.479

High

247862

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

274551

DNJB6
DnaJ homolog subfamily B member 6

1

11

High-throughput

0.479

High

298370

DNJC8
DnaJ homolog subfamily C member 8

1

11

High-throughput

0.479

High

330912

KI20A
Kinesin-like protein KIF20A

1

18

High-throughput

0.479

High

404011

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

413719

P53
Cellular tumor antigen p53

1

11

High-throughput

0.479

High

473949

NFIC
Nuclear factor 1 C-type

1

11

High-throughput

0.479

High

487237

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

588558

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

695313

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

731237

STIP1
Stress-induced-phosphoprotein 1

1

14

High-throughput

0.479

High

768054

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

799043

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.479

High

830634

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

872259

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.479

High

879017

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

937730

FOXA1
Hepatocyte nuclear factor 3-alpha

1

11

High-throughput

0.479

High

964894

WDR5
WD repeat-containing protein 5

1

17

High-throughput

0.479

High

982635

RS24
Small ribosomal subunit protein eS24

1

3

High-throughput

0.479

High

984731

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.479

High

1004496

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

1032154

EXOSX
Exosome complex component 10

1

6

High-throughput

0.479

High

1035572

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

1040782

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

1085648

GRSF1
G-rich sequence factor 1

1

20

High-throughput

0.479

High

1085650

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1085657

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

1085661

E2F4
Transcription factor E2F4

1

5

High-throughput

0.479

High

1085668

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1085669

IFIX
Pyrin and HIN domain-containing protein 1

1

11

High-throughput

0.479

High

1085670

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

1085675

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1085677

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1085680

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

1085683

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1085685

DNJC9
DnaJ homolog subfamily C member 9

1

15

High-throughput

0.479

High

1085688

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1085689

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1085690

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1085694

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1085705

YTHD1
YTH domain-containing family protein 1

1

8

High-throughput

0.479

High

1085707

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.479

High

1085711

ECT2
Protein ECT2

1

16

High-throughput

0.479

High

1085712

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1085717

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

1085719

DJC17
DnaJ homolog subfamily C member 17

1

16

High-throughput

0.479

High

1085721

AATF
Protein AATF

1

9

High-throughput

0.479

High

1085722

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

1085732

CE164
Centrosomal protein of 164 kDa

1

18

High-throughput

0.479

High

1085733

NUDC
Nuclear migration protein nudC

1

11

High-throughput

0.479

High

1085736

YTHD2
YTH domain-containing family protein 2

1

10

High-throughput

0.479

High

291644

XRP2
Protein XRP2

1

0

High-throughput

0.458

High

1085653

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1085666

MIDN
Midnolin

1

0

High-throughput

0.458

High

1085693

AURKB
Aurora kinase B

1

13

High-throughput

0.457

High

288642

NPM3
Nucleoplasmin-3

1

8

High-throughput

0.445

High

429790

JUN
Transcription factor Jun

1

14

High-throughput

0.445

High

584089

FOSL2
Fos-related antigen 2

1

6

High-throughput

0.445

High

686118

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.445

High

911565

NCBP2
Nuclear cap-binding protein subunit 2

1

15

High-throughput

0.445

High

972375

RS14
Small ribosomal subunit protein uS11

1

6

High-throughput

0.445

High

1085652

C1D
Nuclear nucleic acid-binding protein C1D

1

1

High-throughput

0.445

High

1085654

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

7

High-throughput

0.445

High

1085665

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

5

High-throughput

0.445

High

1085667

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1085671

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

1085724

NOP53
Ribosome biogenesis protein NOP53

1

3

High-throughput

0.445

High

131994

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.437

High

241521

PRKN
E3 ubiquitin-protein ligase parkin

1

19

High-throughput

0.437

High

318743

RHBT1
Rho-related BTB domain-containing protein 1

1

15

High-throughput

0.437

High

363195

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.437

High

411823

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

774321

BASI
Basigin

1

3

High-throughput

0.437

High

1085658

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.437

High

1085659

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.437

High

1085672

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1085679

FA43A
Protein FAM43A

1

4

High-throughput

0.437

High

1085691

CHM4C
Charged multivesicular body protein 4c

1

8

High-throughput

0.437

High

1085695

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1085706

RHBT2
Rho-related BTB domain-containing protein 2

1

15

High-throughput

0.437

High

1085708

ATG5
Autophagy protein 5

1

1

High-throughput

0.437

High

1085709

CHM4B
Charged multivesicular body protein 4b

1

8

High-throughput

0.437

High

1085726

KLK11
Kallikrein-11

1

4

High-throughput

0.437

High

1085728

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.437

High

1085699

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1085727

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

131553

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

0

High-throughput

0.282

High

1006242

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.279

Low

1064566

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.279

Low

1085674

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

1085720

FAIM1
Fas apoptotic inhibitory molecule 1

1

0

High-throughput

0.279

Low

1085737

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1085686

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.249

Low

1085700

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025