HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: KLH22 (Q53GT1)
Kelch-like protein 22
Gene: KLHL22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.588

Property	Details
Experiments	32814053, 37788672
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 634
+	Hs
		1096171 TADBP_HUMAN (1-414): 1.68e-85: 268: 100.00		KLH32_HUMAN (28-595): 0: 528: 29.39
+	Hs
		1120185 HNRPD_HUMAN (81-238): 5.61e-21: 95.1: 35.93		KLH22_HUMAN (1-634): 2.13e-169: 499: 100.00
+	Hs
		1096281 TADBP_HUMAN (1-414): 1.68e-85: 268: 100.00		KLH20_HUMAN (380-632): 1.91e-67: 233: 21.57
+	Dm
		877798 RB27C_DROME (99-400): 4.25e-73: 236: 28.17		KELC_DROME (401-632): 2.33e-59: 217: 18.97
+	Hs
		1096032 TADBP_HUMAN (1-414): 1.68e-85: 268: 100.00		KLH26_HUMAN (378-633): 1.94e-23: 106: 16.30
+	Hs
		1096097 TADBP_HUMAN (1-414): 1.68e-85: 268: 100.00		KLH36_HUMAN (492-632): 9.46e-20: 95.3: 15.28
+	Hs
		1096056 TADBP_HUMAN (1-414): 1.68e-85: 268: 100.00		KLH17_HUMAN (532-632): 3e-12: 71.8: 9.90
+	Dm
		462182 ROA1_DROME (179-271): 1.98e-16: 82.1: 24.24		KELC_DROME (401-632): 2.33e-59: 217: 18.97