HitPredict

Interactor 1: LIN41 (Q2Q1W2)
E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
Gene: TRIM71

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31732746, 24602972
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0035196 - miRNA processing GO:0035198 - miRNA binding GO:0035278 - miRNA-mediated gene silencing by inhibition of translation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 868 Hs			1 859
+	Mm
		1093411 LIN41_MOUSE (1-868): 0: 694: 89.52		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Ce
		108593 LIN41_CAEEL (112-868): 7.35e-135: 432: 31.82		G5EGR6_CAEEL (19-859): 0: 1102: 67.09
+	Hs
		1290902 TRI11_HUMAN (185-610): 8.84e-89: 291: 16.51		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		170508 TIF1A_HUMAN (71-606): 4.56e-80: 281: 17.15		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		164503 TRI66_HUMAN (190-482): 9.43e-77: 274: 19.80		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		585070 RO52_HUMAN (185-608): 5.17e-97: 313: 14.45		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Mm
		1208468 TRI32_MOUSE (186-868): 3.21e-86: 290: 16.76		AGO1_MOUSE (17-859): 0: 1182: 83.16
+	Hs
		170510 TIF1A_HUMAN (71-606): 4.56e-80: 281: 17.15		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1172215 TRI67_HUMAN (50-571): 1.02e-71: 253: 16.47		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		585074 RO52_HUMAN (185-608): 5.17e-97: 313: 14.45		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		170478 TIF1A_HUMAN (71-606): 4.56e-80: 281: 17.15		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1172222 TRI67_HUMAN (50-571): 1.02e-71: 253: 16.47		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		170484 TIF1A_HUMAN (71-606): 4.56e-80: 281: 17.15		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		1171758 TRI67_HUMAN (50-571): 1.02e-71: 253: 16.47		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1282069 TRI63_HUMAN (190-477): 2.85e-61: 213: 18.65		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Dm
		1103819 BRAT_DROME (689-868): 5.87e-30: 130: 34.07		Q32KD4_DROME (6-859): 0: 1136: 73.10
+	Dm
		1100037 BRAT_DROME (689-868): 5.87e-30: 130: 34.07		Q27IR0_DROME (6-813): 0: 1085: 73.67
+	Dm
		1100038 WECH_DROME (737-868): 1.53e-27: 122: 40.15		Q27IR0_DROME (6-813): 0: 1085: 73.67
+	Ce
		247863 LIN41_CAEEL (112-868): 7.35e-135: 432: 31.82		ERGO1_CAEEL (304-817): 7.03e-56: 211: 28.69
+	Ce
		1094449 LIN41_CAEEL (112-868): 7.35e-135: 432: 31.82		WAGO1_CAEEL (192-814): 8.66e-36: 148: 25.54