Protein: IFIT3
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)

Gene: IFIT3
Organism: Homo sapiens
Interactions: 88
UniProt ID: O14879

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation
GO:0009615 - response to virus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

166749

IFIT1
Antiviral innate immune response effector IFIT1

7

14

High-throughput

0.977

High

166748

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

6

14

High-throughput

0.947

High

166789

IFT1B
Protein IFIT1 homolog B

3

14

High-throughput

0.858

High

166724

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

2

13

High-throughput

0.815

High

166782

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

2

13

High-throughput

0.793

High

166795

Q8IZ03
Interferon-induced protein with tetratricopeptide repeats 2

2

14

High-throughput

0.688

High

166740

TPM3
Tropomyosin alpha-3 chain

3

3

High-throughput

0.678

High

166730

IFNA2
Interferon alpha-2

3

11

High-throughput

0.667

High

166734

IFN14
Interferon alpha-14

3

11

High-throughput

0.667

High

166760

IFNA8
Interferon alpha-8

3

11

High-throughput

0.667

High

166728

RIGI
Antiviral innate immune response receptor RIG-I

1

5

Small-scale

0.665

High

166776

DEUP1
Deuterosome assembly protein 1

2

5

High-throughput

0.646

High

166732

IFN21
Interferon alpha-21

2

11

High-throughput

0.628

High

166796

PHAR4
Phosphatase and actin regulator 4

2

7

High-throughput

0.628

High

166787

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.599

High

166737

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.590

High

166745

TPM1
Tropomyosin alpha-1 chain

1

2

High-throughput

0.582

High

166799

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.573

High

166800

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.549

High

166735

APOE
Apolipoprotein E

1

1

High-throughput

0.541

High

166761

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.541

High

166766

RD23A
UV excision repair protein RAD23 homolog A

1

4

High-throughput

0.541

High

166808

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.541

High

166725

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

20

High-throughput

0.536

High

166731

IFNA7
Interferon alpha-7

1

11

High-throughput

0.536

High

166739

LA
Lupus La protein

1

16

High-throughput

0.536

High

166746

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

High-throughput

0.536

High

166750

THIO
Thioredoxin

1

3

High-throughput

0.536

High

166752

PABP1
Polyadenylate-binding protein 1

1

13

High-throughput

0.536

High

166753

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

166754

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

18

High-throughput

0.536

High

166755

DESP
Desmoplakin

1

2

High-throughput

0.536

High

166756

YBOX3
Y-box-binding protein 3

1

7

High-throughput

0.536

High

166758

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

20

High-throughput

0.536

High

166759

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.536

High

166768

RUXE
Small nuclear ribonucleoprotein E

1

2

High-throughput

0.536

High

166769

RUXF
Small nuclear ribonucleoprotein F

1

6

High-throughput

0.536

High

166771

SMD2
Small nuclear ribonucleoprotein Sm D2

1

3

High-throughput

0.536

High

166772

SMD3
Small nuclear ribonucleoprotein Sm D3

1

9

High-throughput

0.536

High

166773

YBOX1
Y-box-binding protein 1

1

7

High-throughput

0.536

High

166775

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.536

High

166778

ILF3
Interleukin enhancer-binding factor 3

1

7

High-throughput

0.536

High

166781

PABP4
Polyadenylate-binding protein 4

1

13

High-throughput

0.536

High

166783

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.536

High

166801

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

20

High-throughput

0.536

High

166805

MOV10
Helicase MOV-10

1

1

High-throughput

0.536

High

166807

MYH2
Myosin-2

1

1

High-throughput

0.536

High

166779

TRAF2
TNF receptor-associated factor 2

1

8

Small-scale

0.515

High

166780

TRAF3
TNF receptor-associated factor 3

1

10

Small-scale

0.515

High

166784

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

Small-scale

0.515

High

166793

MAVS
Mitochondrial antiviral-signaling protein

1

8

Small-scale

0.515

High

166806

TBK1
Serine/threonine-protein kinase TBK1

1

7

Small-scale

0.515

High

166809

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.515

High

3008

A0A0G2JIW1
Heat shock protein family A

1

3

High-throughput

0.514

High

166729

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.494

High

166764

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

0

High-throughput

0.493

High

166741

RU2B
U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.489

High

166742

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

15

High-throughput

0.489

High

166743

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.489

High

166744

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.489

High

166747

RU2A
U2 small nuclear ribonucleoprotein A'

1

7

High-throughput

0.489

High

166757

NUCL
Nucleolin

1

13

High-throughput

0.489

High

166762

RBMX
RNA-binding motif protein, X chromosome

1

11

High-throughput

0.489

High

166765

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

High-throughput

0.489

High

166791

AMPQ
Aminopeptidase Q

1

3

High-throughput

0.481

High

166802

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

2

High-throughput

0.481

High

166804

RNF32
RING finger protein 32

1

1

High-throughput

0.481

High

166727

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

166733

IFNA5
Interferon alpha-5

1

11

High-throughput

0.479

High

166738

ISG15
Ubiquitin-like protein ISG15

1

10

High-throughput

0.479

High

166767

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

4

High-throughput

0.479

High

166770

SMD1
Small nuclear ribonucleoprotein Sm D1

1

9

High-throughput

0.479

High

166792

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

166797

CGAS
Cyclic GMP-AMP synthase

1

3

High-throughput

0.479

High

166798

SAP25
Histone deacetylase complex subunit SAP25

1

2

Small-scale

0.479

High

166803

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

166777

Q0P5U8
Aminopeptidase

1

3

High-throughput

0.470

High

166790

Q5VU62
TPM3 protein

1

2

High-throughput

0.470

High

166726

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

166751

CP2C8
Cytochrome P450 2C8

1

0

High-throughput

0.460

High

166786

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.458

High

166774

SRSF3
Serine/arginine-rich splicing factor 3

1

15

High-throughput

0.445

High

166788

SRSF7
Serine/arginine-rich splicing factor 7

1

16

High-throughput

0.445

High

166763

PSN2
Presenilin-2

1

1

High-throughput

0.439

High

166785

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.437

High

166736

ANXA1
Annexin A1

1

5

Small-scale

0.408

High

166794

T183A
Transmembrane protein 183A

4

0

High-throughput

0.363

High


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Last updated: 11Aug2025