HitPredict

Interactor 1: CKB12 (Q2V419)
Cyclin-dependent kinase B1-2 (CDKB1;2) (EC 2.7.11.22) (EC 2.7.11.23)
Gene: CDKB1-2

Interactor 2: CCB22 (Q39070)
Cyclin-B2-2 (Cyc2b-At) (Cyclin-2b) (G2/mitotic-specific cyclin-B2-2) (CycB2;2)
Gene: CYCB2-2

Species: Arabidopsis thaliana

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	20706207
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 311 At			1 429
+	At
		1103371 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCB23_ARATH (6-423): 2.75e-126: 374: 51.29
+	Hs
		625350 CDK2_HUMAN (1-309): 2.25e-149: 422: 56.77		CCNA1_HUMAN (34-426): 2.86e-123: 367: 27.16
+	Hs
		538471 CDK2_HUMAN (1-309): 2.25e-149: 422: 56.77		CCNB1_HUMAN (4-427): 2.39e-123: 366: 27.23
+	At
		1103349 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCA23_ARATH (7-423): 3.6e-119: 356: 26.76
+	Hs
		538521 CDK3_HUMAN (1-309): 9.3e-142: 403: 56.77		CCNB1_HUMAN (4-427): 2.39e-123: 366: 27.23
+	At
		1103350 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCB12_ARATH (37-424): 1.17e-117: 352: 36.05
+	Hs
		590125 CDK2_HUMAN (1-309): 2.25e-149: 422: 56.77		CCNA2_HUMAN (5-425): 1.23e-114: 344: 27.61
+	At
		1103366 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCA24_ARATH (2-419): 8.92e-116: 348: 27.53
+	Mm
		956329 CDK2_MOUSE (1-309): 2.79e-140: 401: 49.16		CCNA1_MOUSE (34-426): 9.64e-121: 359: 27.09
+	Hs
		303829 CDK2_HUMAN (1-309): 2.25e-149: 422: 56.77		CCNB2_HUMAN (34-427): 2.36e-112: 337: 30.05
+	At
		1103352 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCA21_ARATH (4-425): 9.73e-114: 342: 29.07
+	At
		672516 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCB11_ARATH (10-425): 9.73e-113: 339: 33.26
+	At
		1059417 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCA22_ARATH (8-421): 6.6e-111: 334: 28.50
+	Hs
		590162 CDK3_HUMAN (1-309): 9.3e-142: 403: 56.77		CCNA2_HUMAN (5-425): 1.23e-114: 344: 27.61
+	At
		1103369 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCA31_ARATH (85-426): 2.46e-110: 330: 28.65
+	Mm
		851183 CDK2_MOUSE (1-309): 2.79e-140: 401: 49.16		CCNA2_MOUSE (5-425): 3.62e-114: 342: 28.61
+	At
		639330 CKB11_ARATH (1-311): 3.89e-139: 397: 87.78		CCB11_ARATH (10-425): 9.73e-113: 339: 33.26
+	At
		1103376 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCB31_ARATH (31-425): 1.27e-104: 317: 33.17
+	At
		639335 CKB11_ARATH (1-311): 3.89e-139: 397: 87.78		CCA22_ARATH (8-421): 6.6e-111: 334: 28.50
+	At
		1103353 CKB12_ARATH (1-311): 1.9e-146: 415: 100.00		CCA34_ARATH (85-425): 4.5e-102: 309: 29.05