Protein: EFHD2
EF-hand domain-containing protein D2 (Swiprosin-1)

Gene: EFHD2
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q96C19

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0045121 - membrane raft
GO:0045296 - cadherin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1385422

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

9

High-throughput

0.574

High

772947

MYH9
Myosin-9

1

20

High-throughput

0.536

High

1385435

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.536

High

396673

ESR1
Estrogen receptor

2

10

High-throughput

0.521

High

1143084

KPCD1
Serine/threonine-protein kinase D1

2

14

High-throughput

0.521

High

1227218

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.521

High

422833

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

329876

OR5F1
Olfactory receptor 5F1

1

1

High-throughput

0.489

High

553407

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

3

High-throughput

0.489

High

946440

MTPN
Myotrophin

1

4

High-throughput

0.489

High

1340018

OR2K2
Olfactory receptor 2K2

1

2

High-throughput

0.489

High

1365566

MY18A
Unconventional myosin-XVIIIa

1

20

High-throughput

0.489

High

1385418

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

6

High-throughput

0.489

High

1385419

RDH12
Retinol dehydrogenase 12

1

4

High-throughput

0.489

High

535392

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

971860

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.479

High

1334742

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1385423

EFHD1
EF-hand domain-containing protein D1

1

15

High-throughput

0.479

High

773244

MYH10
Myosin-10

1

20

High-throughput

0.470

High

556272

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

530194

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

126740

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.437

High

179239

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

4

Small-scale

0.437

High

247406

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

10

High-throughput

0.437

High

248032

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

260280

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

315859

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

346172

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.437

High

372790

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

589364

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

606987

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.437

High

629993

BTF3
Transcription factor BTF3

1

5

High-throughput

0.437

High

650895

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.437

High

696163

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

862358

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.437

High

907528

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

Small-scale

0.437

High

930009

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

3

High-throughput

0.437

High

934975

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.437

High

936963

CASP9
Caspase-9

1

1

Small-scale

0.437

High

945066

RAB25
Ras-related protein Rab-25

1

2

High-throughput

0.437

High

976476

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.437

High

980112

H4
Histone H4

1

1

High-throughput

0.437

High

1026501

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.437

High

1041687

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

Small-scale

0.437

High

1094607

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.437

High

1095217

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

1

Small-scale

0.437

High

1137923

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1138489

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

1139790

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

Small-scale

0.437

High

1156811

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1197537

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.437

High

1209491

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

17

Small-scale

0.437

High

1218623

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.437

High

1245114

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.437

High

1254980

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

1350404

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.437

High

1352333

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.437

High

1361630

SSH1
Protein phosphatase Slingshot homolog 1

1

3

High-throughput

0.437

High

1363816

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.437

High

1364506

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.437

High

1366980

ESR2
Estrogen receptor beta

1

10

High-throughput

0.437

High

1380071

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.437

High

1385417

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.437

High

1385421

OVOL2
Transcription factor Ovo-like 2

1

1

Small-scale

0.437

High

1385424

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.437

High

1385425

RNF38
E3 ubiquitin-protein ligase RNF38

1

7

Small-scale

0.437

High

1385426

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.437

High

1385429

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

1385431

RNF12
E3 ubiquitin-protein ligase RLIM

1

8

High-throughput

0.437

High

1385432

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

1385433

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.437

High

1385434

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

255157

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.407

High

765780

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.407

High

839066

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.407

High

1031839

LAT1
Large neutral amino acids transporter small subunit 1

1

4

High-throughput

0.407

High

1103311

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.407

High

1313787

S15A3
Solute carrier family 15 member 3

1

4

High-throughput

0.407

High

1385436

NAC2
Sodium/calcium exchanger 2

1

3

High-throughput

0.407

High

708998

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.328

High

608326

EGLN
Endoglin

1

0

High-throughput

0.279

Low

947886

T2R41
Taste receptor type 2 member 41

1

0

High-throughput

0.279

Low

1358172

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1385420

UIF
UAP56-interacting factor

1

0

High-throughput

0.279

Low

1385427

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

1385430

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

416761

TYSY
Thymidylate synthase

1

0

High-throughput

0.269

Low

106427

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

210595

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.249

Low

292385

RA51D
DNA repair protein RAD51 homolog 4

1

0

Small-scale

0.249

Low

768847

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

872615

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

1045620

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1127069

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

1226489

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1276613

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1331907

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.249

Low

1385428

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025