HitPredict

Interactor 1: MPP3 (Q13368)
MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)
Gene: MPP3

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	26186194, 28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0030165 - PDZ domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 585 Hs			1 197
+	Hs
		1103523 MPP3_HUMAN (1-585): 3.06e-172: 502: 100.00		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167696 MPP3_HUMAN (1-585): 3.06e-172: 502: 100.00		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		1212215 MPP7_HUMAN (1-584): 5.42e-158: 465: 51.93		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Hs
		1212210 MPP7_HUMAN (1-584): 5.42e-158: 465: 51.93		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167705 MPP7_HUMAN (1-584): 5.42e-158: 465: 51.93		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		1103527 MPP3_HUMAN (1-585): 3.06e-172: 502: 100.00		SNTG2_HUMAN (26-188): 2.96e-32: 123: 25.46
+	Hs
		1122734 MPP2_HUMAN (1-584): 7.18e-146: 435: 30.03		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Hs
		1450016 PALS2_HUMAN (10-584): 2.03e-146: 435: 31.22		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Dm
		54269 A1Z8G0_DROME (3-585): 1.02e-150: 448: 36.98		Q9VBY7_DROME (1-195): 2.79e-52: 168: 80.00
+	Hs
		1122731 MPP2_HUMAN (1-584): 7.18e-146: 435: 30.03		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		1437597 PALS2_HUMAN (10-584): 2.03e-146: 435: 31.22		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167699 MPP2_HUMAN (1-584): 7.18e-146: 435: 30.03		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		167723 PALS2_HUMAN (10-584): 2.03e-146: 435: 31.22		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		708854 MPP7_HUMAN (1-584): 5.42e-158: 465: 51.93		PTN4_HUMAN (43-187): 5.78e-33: 126: 29.14
+	Hs
		1394859 MPP4_HUMAN (8-584): 1.42e-155: 462: 36.29		MPP4_HUMAN (12-174): 9.77e-31: 119: 26.99
+	Rn
		313210 MPP3_RAT (1-585): 6.77e-166: 486: 90.43		DLG1_RAT (94-178): 2.15e-21: 92.9: 37.78
+	Mm
		1223777 MPP2_MOUSE (1-584): 2.68e-146: 435: 31.43		DLG4_MOUSE (14-196): 1.66e-23: 99.1: 22.87
+	Hs
		1091491 MPP2_HUMAN (1-584): 7.18e-146: 435: 30.03		DLG1_HUMAN (50-178): 6.75e-23: 97.1: 30.60
+	Hs
		1212202 MPP7_HUMAN (1-584): 5.42e-158: 465: 51.93		SNX27_HUMAN (91-175): 2.6e-12: 66.6: 38.14
+	Dm
		54265 A1Z8G0_DROME (3-585): 1.02e-150: 448: 36.98		DLG1_DROME (59-176): 3.25e-14: 72.1: 28.46