Protein: PTN4
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)

Gene: PTN4, PTPN4
Organism: Homo sapiens
Interactions: 69
UniProt ID: P29074

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

708835

CRK
Adapter molecule crk

2

18

Small-scale

0.850

High

708854

MPP7
MAGUK p55 subfamily member 7

2

20

High-throughput

0.811

High

708836

CRKL
Crk-like protein

2

20

High-throughput

0.754

High

690756

1433T
14-3-3 protein theta

4

20

High-throughput

0.694

High

708840

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

708844

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.694

High

708847

1433F
14-3-3 protein eta

4

20

High-throughput

0.694

High

708858

KCD17
BTB/POZ domain-containing protein KCTD17

3

20

High-throughput

0.667

High

708832

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.656

High

708838

MK12
Mitogen-activated protein kinase 12

2

8

Small-scale

0.621

High

708871

SCML1
Sex comb on midleg-like protein 1

1

3

High-throughput

0.618

High

362172

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

440390

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

593922

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

699594

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.618

High

708831

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

17

High-throughput

0.618

High

708843

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

708841

1433E
14-3-3 protein epsilon

2

7

High-throughput

0.611

High

708864

SIPA1
Signal-induced proliferation-associated protein 1

1

4

High-throughput

0.575

High

708865

NEB2
Neurabin-2

1

20

High-throughput

0.575

High

708869

NEB1
Neurabin-1

1

20

High-throughput

0.575

High

708867

CADM1
Cell adhesion molecule 1

2

6

High-throughput

0.574

High

708861

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.568

High

687893

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.541

High

708834

ATRX
Transcriptional regulator ATRX

1

4

High-throughput

0.541

High

708845

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.541

High

354554

PAK4
Serine/threonine-protein kinase PAK 4

1

8

High-throughput

0.536

High

552757

TPR
Nucleoprotein TPR

1

10

High-throughput

0.536

High

708842

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

High-throughput

0.536

High

708850

CAPR1
Caprin-1

1

1

High-throughput

0.536

High

708872

SRRM2
Serine/arginine repetitive matrix protein 2

1

15

High-throughput

0.536

High

708849

NMDE1
Glutamate receptor ionotropic, NMDA 2A

2

19

Small-scale

0.521

High

280520

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.515

High

708839

CASP6
Caspase-6

1

1

High-throughput

0.515

High

548852

ADHX
Alcohol dehydrogenase class-3

1

0

High-throughput

0.513

High

708833

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.513

High

708855

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

405402

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.508

High

215874

GRID2
Glutamate receptor ionotropic, delta-2

1

20

Small-scale

0.504

High

207797

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

2

High-throughput

0.494

High

449506

LIPL
Lipoprotein lipase

1

1

High-throughput

0.494

High

708873

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.493

High

136480

GOLI4
Golgi integral membrane protein 4

1

7

High-throughput

0.489

High

619527

VCAM1
Vascular cell adhesion protein 1

1

11

High-throughput

0.489

High

708851

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

7

High-throughput

0.489

High

708859

SHKB1
SH3KBP1-binding protein 1

1

20

High-throughput

0.489

High

708870

ICAM5
Intercellular adhesion molecule 5

1

14

High-throughput

0.489

High

164799

UN13B
Protein unc-13 homolog B

1

5

High-throughput

0.479

High

187012

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.479

High

625206

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.479

High

708846

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.479

High

708852

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

708863

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

High-throughput

0.479

High

708866

NP1L4
Nucleosome assembly protein 1-like 4

1

4

High-throughput

0.479

High

708868

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

561910

LAMP2
Lysosome-associated membrane glycoprotein 2

1

10

High-throughput

0.470

High

596855

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

51045

PKHG3
Pleckstrin homology domain-containing family G member 3

1

8

High-throughput

0.445

High

708837

NEST
Nestin

1

12

High-throughput

0.445

High

708853

PLEC
Plectin

1

5

High-throughput

0.445

High

708856

SYNPO
Synaptopodin

1

14

High-throughput

0.445

High

336355

SVIL
Supervillin

1

0

High-throughput

0.426

High

593637

BGAL
Beta-galactosidase

1

0

High-throughput

0.426

High

708848

NEXN
Nexilin

1

10

High-throughput

0.407

High

708857

CTL3
Choline transporter-like protein 3

1

4

High-throughput

0.407

High

708860

ZN418
Zinc finger protein 418

1

0

High-throughput

0.279

Low

441526

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

708862

ARK2N
Protein ARK2N

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025