HitPredict

Interactor 1: MPP2 (Q14168)
MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)
Gene: MPP2

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.940

Property	Details
Experiments	26186194, 28514442, 32296183, 33961781, unassigned1304, unassigned3799
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 576 Hs			1 197
+	Hs
		1122731 MPP2_HUMAN (1-576): 0: 590: 100.00		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167699 MPP2_HUMAN (1-576): 0: 590: 100.00		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		1450016 PALS2_HUMAN (12-576): 0: 524: 66.31		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Hs
		1437597 PALS2_HUMAN (12-576): 0: 524: 66.31		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167723 PALS2_HUMAN (12-576): 0: 524: 66.31		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		1091491 MPP2_HUMAN (1-576): 0: 590: 100.00		DLG1_HUMAN (50-178): 6.75e-23: 97.1: 30.60
+	Dm
		122386 M9PJD0_DROME (134-576): 2.61e-158: 498: 33.13		Q9VBY7_DROME (1-195): 2.79e-52: 168: 80.00
+	Mm
		1223777 MPP2_MOUSE (1-576): 0: 558: 93.40		DLG4_MOUSE (14-196): 1.66e-23: 99.1: 22.87
+	Hs
		1212215 MPP7_HUMAN (1-576): 1.46e-152: 452: 34.00		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Dm
		1172961 CSKP_DROME (1-576): 3.67e-152: 461: 37.31		Q9VBY7_DROME (1-195): 2.79e-52: 168: 80.00
+	Hs
		1212210 MPP7_HUMAN (1-576): 1.46e-152: 452: 34.00		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167670 CSKP_HUMAN (7-576): 2.86e-148: 452: 36.33		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		167705 MPP7_HUMAN (1-576): 1.46e-152: 452: 34.00		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		708854 MPP7_HUMAN (1-576): 1.46e-152: 452: 34.00		PTN4_HUMAN (43-187): 5.78e-33: 126: 29.14
+	Hs
		168683 CSKP_HUMAN (7-576): 2.86e-148: 452: 36.33		SNTB2_HUMAN (61-179): 3.01e-32: 123: 35.25
+	Hs
		168585 CSKP_HUMAN (7-576): 2.86e-148: 452: 36.33		CSKP_HUMAN (13-194): 7.06e-31: 120: 20.53
+	Hs
		168670 CSKP_HUMAN (7-576): 2.86e-148: 452: 36.33		DLG4_HUMAN (14-196): 4.48e-23: 97.9: 22.87
+	Hs
		168680 CSKP_HUMAN (7-576): 2.86e-148: 452: 36.33		DLG1_HUMAN (50-178): 6.75e-23: 97.1: 30.60
+	Hs
		168730 CSKP_HUMAN (7-576): 2.86e-148: 452: 36.33		DLG3_HUMAN (74-164): 8.63e-20: 88.3: 35.42
+	Hs
		1212202 MPP7_HUMAN (1-576): 1.46e-152: 452: 34.00		SNX27_HUMAN (91-175): 2.6e-12: 66.6: 38.14