HitPredict

Interactor 1: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Interactor 2: UB2E3 (Q969T4)
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
Gene: UBE2E3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 207
+	Hs
		718419 PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03		UB2E2_HUMAN (1-207): 5.59e-89: 261: 85.02
+	Hs
		895802 PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		717650 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		717615 BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		718384 PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		584923 RO52_HUMAN (2-241): 3.02e-47: 164: 15.56		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		584907 RO52_HUMAN (2-241): 3.02e-47: 164: 15.56		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		584916 RO52_HUMAN (2-241): 3.02e-47: 164: 15.56		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		584910 RO52_HUMAN (2-241): 3.02e-47: 164: 15.56		UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36
+	Hs
		849366 TRI22_HUMAN (2-237): 1.71e-43: 155: 16.15		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895893 PCGF1_HUMAN (3-238): 1.66e-45: 154: 38.33		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		1318719 TRIM5_HUMAN (2-238): 5.65e-41: 148: 16.60		UB2D4_HUMAN (61-206): 1.19e-82: 243: 63.01
+	Hs
		919853 TRIM5_HUMAN (2-238): 5.65e-41: 148: 16.60		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		849439 TRIM5_HUMAN (2-238): 5.65e-41: 148: 16.60		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895898 PCGF6_HUMAN (3-235): 4.63e-43: 150: 33.62		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		895905 TRIM5_HUMAN (2-238): 5.65e-41: 148: 16.60		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		849399 TRI43_HUMAN (11-242): 4.59e-39: 142: 15.98		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895870 TRI43_HUMAN (11-242): 4.59e-39: 142: 15.98		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		584918 RO52_HUMAN (2-241): 3.02e-47: 164: 15.56		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27
+	Hs
		896538 TRIM5_HUMAN (2-238): 5.65e-41: 148: 16.60		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27