Protein: CDK13
Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)

Gene: CDK13
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q14004

Gene Ontology (top 5):
GO:0000380 - alternative mRNA splicing, via spliceosome
GO:0002945 - cyclin K-CDK13 complex
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296988

CCNK
Cyclin-K

7

20

Small-scale

0.968

High

461465

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.903

High

468363

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.903

High

1105913

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

17

High-throughput

0.903

High

908884

NEK3
Serine/threonine-protein kinase Nek3

3

14

High-throughput

0.861

High

1119679

DUSTY
Dual serine/threonine and tyrosine protein kinase

3

13

High-throughput

0.861

High

1119696

RBM14
RNA-binding protein 14

3

13

High-throughput

0.861

High

1119711

CDK12
Cyclin-dependent kinase 12

3

18

High-throughput

0.861

High

1006389

SRPK2
SRSF protein kinase 2

3

19

High-throughput

0.853

High

1119669

CDC37
Hsp90 co-chaperone Cdc37

3

10

High-throughput

0.847

High

549150

CDK4
Cyclin-dependent kinase 4

2

17

High-throughput

0.811

High

667838

CDK2
Cyclin-dependent kinase 2

2

14

High-throughput

0.811

High

1060976

SRSF1
Serine/arginine-rich splicing factor 1

2

20

Small-scale

0.799

High

1119662

PLSI
Plastin-1

2

16

High-throughput

0.789

High

1119673

LARP7
La-related protein 7

2

18

High-throughput

0.789

High

1099071

SRSF5
Serine/arginine-rich splicing factor 5

2

20

High-throughput

0.776

High

1119674

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

1119676

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

1119677

HS904
Putative heat shock protein HSP 90-alpha A4

2

20

High-throughput

0.712

High

443356

CDK1
Cyclin-dependent kinase 1

1

14

High-throughput

0.691

High

854046

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.691

High

897802

CDK9
Cyclin-dependent kinase 9

1

16

High-throughput

0.691

High

1016436

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

1061987

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1099338

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

1119691

PSPC1
Paraspeckle component 1

1

17

High-throughput

0.691

High

1119700

ZNF2
Zinc finger protein 2

1

2

High-throughput

0.691

High

1119722

SRPK3
SRSF protein kinase 3

1

19

High-throughput

0.691

High

442707

RB
Retinoblastoma-associated protein

3

15

High-throughput

0.667

High

996947

TBA4A
Tubulin alpha-4A chain

3

12

High-throughput

0.667

High

1119659

KEAP1
Kelch-like ECH-associated protein 1

3

2

High-throughput

0.667

High

1119678

SPSB3
SPRY domain-containing SOCS box protein 3

3

12

High-throughput

0.667

High

1119705

FBX44
F-box only protein 44

3

3

High-throughput

0.667

High

1058012

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

3

2

Small-scale

0.660

High

1119683

FBX11
F-box only protein 11

3

0

High-throughput

0.638

High

363264

EGFR
Epidermal growth factor receptor

1

14

High-throughput

0.618

High

400813

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

411903

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

830708

CCNF
Cyclin-F

1

20

High-throughput

0.618

High

995583

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.618

High

1119661

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.618

High

1119688

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.618

High

1119698

BARD1
BRCA1-associated RING domain protein 1

1

12

High-throughput

0.618

High

1119721

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.618

High

457431

TBB5
Tubulin beta chain

2

14

High-throughput

0.611

High

997333

TBB4B
Tubulin beta-4B chain

2

14

High-throughput

0.611

High

1119681

TBA1A
Tubulin alpha-1A chain

2

15

High-throughput

0.611

High

1119671

EDRF1
Erythroid differentiation-related factor 1

2

0

High-throughput

0.585

High

1119719

PALD
Paladin

2

0

High-throughput

0.585

High

285656

BAF
Barrier-to-autointegration factor

2

1

High-throughput

0.584

High

1119665

RNPS1
RNA-binding protein with serine-rich domain 1

1

16

High-throughput

0.575

High

1119675

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

396082

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1119672

TBB8
Tubulin beta-8 chain

2

14

High-throughput

0.558

High

1119720

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.553

High

124776

AIP
AH receptor-interacting protein

1

14

High-throughput

0.536

High

191638

MAGB2
Melanoma-associated antigen B2

1

4

High-throughput

0.536

High

408062

TBB4A
Tubulin beta-4A chain

1

14

High-throughput

0.536

High

428758

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.536

High

521679

H14
Histone H1.4

1

20

High-throughput

0.536

High

565899

EF2
Elongation factor 2

1

8

High-throughput

0.536

High

595426

H15
Histone H1.5

1

20

High-throughput

0.536

High

658169

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.536

High

686150

RL13
Large ribosomal subunit protein eL13

1

4

High-throughput

0.536

High

732582

ARRB2
Beta-arrestin-2

1

5

High-throughput

0.536

High

785157

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

824137

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

881916

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

916656

PPP5
Serine/threonine-protein phosphatase 5

1

18

High-throughput

0.536

High

969852

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.536

High

971510

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.536

High

978519

RL23A
Large ribosomal subunit protein uL23

1

5

High-throughput

0.536

High

1112012

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

1119660

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.536

High

1119690

DDX54
ATP-dependent RNA helicase DDX54

1

10

High-throughput

0.536

High

1119716

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

1119718

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

1119723

SGT1
Protein SGT1 homolog

1

8

High-throughput

0.536

High

1119724

MYO5A
Unconventional myosin-Va

1

14

High-throughput

0.536

High

1119726

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.536

High

886843

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.527

High

1119670

H31T
Histone H3.1t

1

7

High-throughput

0.515

High

261951

RNH1
Ribonuclease H1

1

0

High-throughput

0.513

High

483573

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

1119712

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

1119725

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

280611

PR40A
Pre-mRNA-processing factor 40 homolog A

1

11

High-throughput

0.508

High

1119702

CHM4A
Charged multivesicular body protein 4a

1

4

High-throughput

0.508

High

137717

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.489

High

829384

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.489

High

1119666

K1H1
Keratin, type I cuticular Ha1

1

5

High-throughput

0.481

High

1119703

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

8

High-throughput

0.481

High

182292

WDR46
WD repeat-containing protein 46

1

13

High-throughput

0.479

High

259929

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

293673

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

324851

HEXI1
Protein HEXIM1

1

12

High-throughput

0.479

High

406163

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.479

High

487293

PARP1
Poly [ADP-ribose] polymerase 1

1

14

High-throughput

0.479

High

504893

H2AB2
Histone H2A-Bbd type 2/3

1

9

High-throughput

0.479

High

588661

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.479

High

606748

CEBPB
CCAAT/enhancer-binding protein beta

1

15

High-throughput

0.479

High

621640

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

646839

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

695422

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

768153

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

791377

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

928443

TERF1
Telomeric repeat-binding factor 1

1

15

High-throughput

0.479

High

968292

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

16

High-throughput

0.479

High

979633

H4
Histone H4

1

6

High-throughput

0.479

High

984109

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

8

High-throughput

0.479

High

992170

SKP1
S-phase kinase-associated protein 1

1

7

High-throughput

0.479

High

998301

H31
Histone H3.1

1

7

High-throughput

0.479

High

1096682

RFA4
Replication protein A 30 kDa subunit

1

10

High-throughput

0.479

High

1108530

TBB3
Tubulin beta-3 chain

1

14

High-throughput

0.479

High

1119663

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

1119664

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1119667

TERF2
Telomeric repeat-binding factor 2

1

17

High-throughput

0.479

High

1119668

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1119680

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

1119682

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1119687

SERB1
SERPINE1 mRNA-binding protein 1

1

8

High-throughput

0.479

High

1119692

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1119693

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

1

9

High-throughput

0.479

High

1119697

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1119699

TBA1C
Tubulin alpha-1C chain

1

15

High-throughput

0.479

High

1119701

DDX23
Probable ATP-dependent RNA helicase DDX23

1

11

High-throughput

0.479

High

1119704

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.479

High

1119707

RC3H2
Roquin-2

1

11

High-throughput

0.479

High

1119709

RNC
Ribonuclease 3

1

1

High-throughput

0.479

High

1119710

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1119714

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

1119715

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1119717

XPO7
Exportin-7

1

3

High-throughput

0.479

High

194183

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

390567

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

716382

BLVRB
Flavin reductase

1

0

High-throughput

0.458

High

1119694

CHMP6
Charged multivesicular body protein 6

1

4

High-throughput

0.457

High

1119713

CHMP5
Charged multivesicular body protein 5

1

4

High-throughput

0.457

High

1119706

LN28A
Protein lin-28 homolog A

1

9

High-throughput

0.445

High

1119708

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1119685

TTC9C
Tetratricopeptide repeat protein 9C

1

17

High-throughput

0.437

High

1119689

LNX1
E3 ubiquitin-protein ligase LNX

1

8

Small-scale

0.437

High

72771

B0UZZ8
WD repeat-containing protein 46

1

13

High-throughput

0.407

High

1119686

S35G3
Solute carrier family 35 member G3

1

2

High-throughput

0.407

High

1119695

JPH4
Junctophilin-4

2

0

High-throughput

0.328

High

1119684

TRM44
Probable tRNA

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025