HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: LRC14 (Q15048)
Leucine-rich repeat-containing protein 14
Gene: LRRC14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	33961781, 21145461, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 493
+	Hs
		821 CUL2_HUMAN (1-745): 0: 839: 100.00		A0A096LNW4_HUMAN (3-488): 1.08e-155: 452: 27.93
+	Hs
		339032 CUL2_HUMAN (1-745): 0: 839: 100.00		PRA12_HUMAN (3-488): 1.52e-151: 442: 25.87
+	Hs
		1112874 CUL2_HUMAN (1-745): 0: 839: 100.00		PRA17_HUMAN (3-488): 2.08e-147: 431: 21.97
+	Hs
		256548 CUL2_HUMAN (1-745): 0: 839: 100.00		PRAM2_HUMAN (3-488): 4.66e-137: 405: 23.82
+	Hs
		1007559 CUL2_HUMAN (1-745): 0: 839: 100.00		PRAME_HUMAN (2-488): 5.5e-135: 401: 29.38
+	Hs
		1113345 CUL3_HUMAN (1-745): 0: 763: 26.38		PRA20_HUMAN (3-493): 7.03e-151: 440: 27.24
+	Hs
		1112663 CUL1_HUMAN (6-745): 0: 770: 36.24		NLRP3_HUMAN (316-462): 9.37e-24: 107: 20.95
+	Hs
		1115007 CUL4A_HUMAN (4-745): 0: 770: 26.86		NLRP3_HUMAN (316-462): 9.37e-24: 107: 20.95
+	Hs
		1115367 CUL4B_HUMAN (4-745): 0: 767: 27.79		NLRP3_HUMAN (316-462): 9.37e-24: 107: 20.95
+	Hs
		562596 CUL3_HUMAN (1-745): 0: 763: 26.38		RINI_HUMAN (286-447): 4.17e-25: 109: 21.47
+	Hs
		1114048 CUL3_HUMAN (1-745): 0: 763: 26.38		NLRP3_HUMAN (316-462): 9.37e-24: 107: 20.95
+	Hs
		1115042 CUL4A_HUMAN (4-745): 0: 770: 26.86		NLRP1_HUMAN (168-329): 7.12e-19: 92.4: 18.45
+	Hs
		1115407 CUL4B_HUMAN (4-745): 0: 767: 27.79		NLRP1_HUMAN (168-329): 7.12e-19: 92.4: 18.45
+	Hs
		1114226 CUL3_HUMAN (1-745): 0: 763: 26.38		NLRP1_HUMAN (168-329): 7.12e-19: 92.4: 18.45