Protein: NLRP1
NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]

Gene: NLRP1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q9C000

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
GO:0003690 - double-stranded DNA binding
GO:0003725 - double-stranded RNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712889

CASP1
Caspase-1

4

20

Small-scale

0.881

High

522131

BCL2
Apoptosis regulator Bcl-2

2

2

Small-scale

0.812

High

1060220

B2CL1
Bcl-2-like protein 1

2

2

Small-scale

0.812

High

1420419

ASC
Apoptosis-associated speck-like protein containing a CARD

2

19

Small-scale

0.789

High

1420415

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

16

Small-scale

0.770

High

936968

CASP9
Caspase-9

2

20

Small-scale

0.754

High

1420416

NLRC4
NLR family CARD domain-containing protein 4

2

19

Small-scale

0.754

High

161749

APAF
Apoptotic protease-activating factor 1

1

1

Small-scale

0.691

High

909176

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.691

High

987467

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

High-throughput

0.665

High

1158178

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.647

High

194788

MEFV
Pyrin

1

14

Small-scale

0.618

High

528342

THIO
Thioredoxin

1

4

Small-scale

0.618

High

624139

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

9

Small-scale

0.618

High

840124

CASP2
Caspase-2

1

20

Small-scale

0.618

High

897965

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.618

High

908560

CASP5
Caspase-5

1

20

Small-scale

0.618

High

1250396

DPP8
Dipeptidyl peptidase 8

1

2

Small-scale

0.618

High

1287285

DPP9
Dipeptidyl peptidase 9

1

2

Small-scale

0.618

High

1416600

CARD6
Caspase recruitment domain-containing protein 6

1

8

Small-scale

0.618

High

1420414

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

18

Small-scale

0.618

High

1201302

PYDC2
Pyrin domain-containing protein 2

1

20

Small-scale

0.590

High

1328667

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.536

High

387323

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

132283

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

Small-scale

0.479

High

408155

TBB4A
Tubulin beta-4A chain

1

3

Small-scale

0.479

High

727952

DNJA1
DnaJ homolog subfamily A member 1

1

8

Small-scale

0.479

High

997113

TBA4A
Tubulin alpha-4A chain

1

5

Small-scale

0.479

High

997497

TBB4B
Tubulin beta-4B chain

1

3

Small-scale

0.479

High

1114226

CUL3
Cullin-3

1

13

Small-scale

0.479

High

1115042

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

1115407

CUL4B
Cullin-4B

1

13

High-throughput

0.479

High

1116295

PTC1
Protein patched homolog 1

1

2

Small-scale

0.479

High

1125219

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.479

High

1181012

TR16L
Tripartite motif-containing protein 16-like protein

1

20

Small-scale

0.479

High

1220531

MIC13
MICOS complex subunit MIC13

1

1

Small-scale

0.479

High

1231193

TRI68
E3 ubiquitin-protein ligase TRIM68

1

15

Small-scale

0.479

High

1245060

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

Small-scale

0.479

High

1259480

TBA1A
Tubulin alpha-1A chain

1

6

Small-scale

0.479

High

1325521

FBXW8
F-box/WD repeat-containing protein 8

1

2

Small-scale

0.479

High

1361479

IFT81
Intraflagellar transport protein 81 homolog

1

4

Small-scale

0.479

High

1366745

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

5

Small-scale

0.479

High

1380902

ARL11
ADP-ribosylation factor-like protein 11

1

4

Small-scale

0.479

High

1410577

TBA1C
Tubulin alpha-1C chain

1

6

Small-scale

0.479

High

1420417

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

Small-scale

0.479

High

1420418

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.479

High

245384

AT10A
Phospholipid-transporting ATPase VA

1

0

Small-scale

0.458

High

1029377

SET
Protein SET

1

0

Small-scale

0.458

High

1256672

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025