HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: SN (Q9BZZ2)
Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169)
Gene: SIGLEC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37788672
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0016020 - membrane GO:0032480 - negative regulation of type I interferon production
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1709
+	Hs
		1114076 CUL3_HUMAN (1-768): 0: 943: 100.00		HMCN1_HUMAN (14-709): 1.02e-86: 318: 16.53
+	Hs
		1113628 CUL3_HUMAN (1-768): 0: 943: 100.00		CNTN4_HUMAN (12-786): 8.19e-49: 192: 13.18
+	Hs
		1113861 CUL3_HUMAN (1-768): 0: 943: 100.00		TITIN_HUMAN (1622-1706): 3.08e-09: 64.7: 13.95
+	Hs
		1022536 CUL3_HUMAN (1-768): 0: 943: 100.00		PGBM_HUMAN (572-733): 3.34e-09: 64.3: 14.29
+	Hs
		1114881 CUL4A_HUMAN (10-768): 0: 801: 38.32		OBSCN_HUMAN (599-805): 7.25e-12: 73.2: 13.95
+	Hs
		1114963 CUL4A_HUMAN (10-768): 0: 801: 38.32		TITIN_HUMAN (1622-1706): 3.08e-09: 64.7: 13.95
+	Hs
		1022537 CUL4A_HUMAN (10-768): 0: 801: 38.32		PGBM_HUMAN (572-733): 3.34e-09: 64.3: 14.29
+	Hs
		1115326 CUL4B_HUMAN (5-768): 0: 796: 36.77		TITIN_HUMAN (1622-1706): 3.08e-09: 64.7: 13.95
+	Hs
		1112933 CUL2_HUMAN (30-768): 0: 673: 26.17		TITIN_HUMAN (1622-1706): 3.08e-09: 64.7: 13.95