HitPredict

Interactor 1: FBW1A (Q3ULA2)
F-box/WD repeat-containing protein 1A (Beta-TrCP protein E3RS-IkappaB) (Beta-transducin repeat-containing protein) (Beta-TrCP) (E3RSIkappaB) (mE3RS-IkappaB) (F-box and WD repeats protein beta-TrCP) (HOS) (Ubiquitin ligase FWD1) (pIkappaB-E3 receptor subunit)
Gene: Btrc

Interactor 2: HDAC5 (Q9Z2V6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Histone deacetylase mHDA1)
Gene: HDAC5

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	31040226
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 605 Mm			1 1113
+	Mm
		1112754 FBW1A_MOUSE (1-605): 0: 582: 100.00		Q3UJF1_MOUSE (1-1113): 0: 711: 99.28
+	Mm
		1131319 FBW1B_MOUSE (110-605): 4.45e-147: 437: 87.50		HDAC5_MOUSE (1-1113): 0: 721: 100.00
+	Mm
		1112755 FBW1B_MOUSE (110-605): 4.45e-147: 437: 87.50		Q3UJF1_MOUSE (1-1113): 0: 711: 99.28
+	Hs
		903610 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		HDAC5_HUMAN (1-1113): 0: 686: 92.79
+	Hs
		245649 TBL1X_HUMAN (501-605): 1.66e-14: 78.5: 19.13		HDAC5_HUMAN (1-1113): 0: 686: 92.79
+	Hs
		245584 TBL1X_HUMAN (501-605): 1.66e-14: 78.5: 19.13		HDAC4_HUMAN (1-1093): 0: 639: 55.65
+	Hs
		880817 TBL1R_HUMAN (501-605): 2.18e-14: 78.1: 16.67		HDAC4_HUMAN (1-1093): 0: 639: 55.65
+	Hs
		1260173 FBXW7_HUMAN (409-603): 5.92e-53: 194: 31.63		HDAC7_HUMAN (111-1113): 3.75e-162: 506: 41.19
+	Hs
		1270358 FBXW7_HUMAN (409-603): 5.92e-53: 194: 31.63		HDAC2_HUMAN (675-1112): 3.29e-156: 475: 21.59
+	Hs
		903202 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		HDAC1_HUMAN (664-1070): 8.93e-160: 484: 21.85
+	Hs
		903404 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		HDAC2_HUMAN (675-1112): 3.29e-156: 475: 21.59
+	Hs
		177249 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		HDAC3_HUMAN (670-1110): 9e-150: 456: 21.13
+	Hs
		245622 TBL1X_HUMAN (501-605): 1.66e-14: 78.5: 19.13		HDAC7_HUMAN (111-1113): 3.75e-162: 506: 41.19
+	Hs
		1260185 TBL1R_HUMAN (501-605): 2.18e-14: 78.1: 16.67		HDAC7_HUMAN (111-1113): 3.75e-162: 506: 41.19
+	Hs
		245600 TBL1X_HUMAN (501-605): 1.66e-14: 78.5: 19.13		HDAC1_HUMAN (664-1070): 8.93e-160: 484: 21.85
+	Hs
		1038686 TBL1R_HUMAN (501-605): 2.18e-14: 78.1: 16.67		HDAC1_HUMAN (664-1070): 8.93e-160: 484: 21.85
+	Hs
		245623 TBL1X_HUMAN (501-605): 1.66e-14: 78.5: 19.13		HDAC2_HUMAN (675-1112): 3.29e-156: 475: 21.59
+	Hs
		1270423 TBL1R_HUMAN (501-605): 2.18e-14: 78.1: 16.67		HDAC2_HUMAN (675-1112): 3.29e-156: 475: 21.59
+	Hs
		177148 TBL1X_HUMAN (501-605): 1.66e-14: 78.5: 19.13		HDAC3_HUMAN (670-1110): 9e-150: 456: 21.13
+	Hs
		177377 TBL1R_HUMAN (501-605): 2.18e-14: 78.1: 16.67		HDAC3_HUMAN (670-1110): 9e-150: 456: 21.13