Protein: KLC3
Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)

Gene: KLC3
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q6P597

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005871 - kinesin complex
GO:0005874 - microtubule
GO:0007018 - microtubule-based movement

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060529

KLC1
Kinesin light chain 1

5

15

High-throughput

0.919

High

1242697

KLC2
Kinesin light chain 2

3

18

High-throughput

0.871

High

1242701

KLC4
Kinesin light chain 4

2

18

High-throughput

0.811

High

1242664

KLC3
Kinesin light chain 3

2

17

High-throughput

0.806

High

50138

BICL2
BICD family-like cargo adapter 2

4

9

High-throughput

0.698

High

1049433

1433F
14-3-3 protein eta

4

20

Small-scale

0.694

High

971654

1433E
14-3-3 protein epsilon

4

8

High-throughput

0.694

High

990365

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.691

High

729956

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.687

High

966479

1433G
14-3-3 protein gamma

4

20

High-throughput

0.681

High

1242690

TSNAX
Translin-associated protein X

4

0

High-throughput

0.676

High

749935

KINH
Kinesin-1 heavy chain

3

20

High-throughput

0.675

High

930944

HSP72
Heat shock-related 70 kDa protein 2

1

7

High-throughput

0.665

High

1242676

BBS5
BBSome complex member BBS5

1

1

High-throughput

0.662

High

1242673

CE57L
Centrosomal protein CEP57L1

2

3

High-throughput

0.633

High

1112881

CUL2
Cullin-2

1

7

High-throughput

0.618

High

1242675

SYNE4
Nesprin-4

3

7

High-throughput

0.609

High

1242698

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

1

High-throughput

0.606

High

1242707

KLH21
Kelch-like protein 21

2

2

High-throughput

0.606

High

691137

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

1242677

USBP1
Harmonin-binding protein USHBP1

3

4

High-throughput

0.597

High

1242684

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.580

High

1242711

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

109557

G5E9S8
Kinesin light chain

1

16

High-throughput

0.575

High

553751

MYCL
Protein L-Myc

2

7

High-throughput

0.574

High

908703

CCNH
Cyclin-H

2

3

High-throughput

0.573

High

163978

NDC80
Kinetochore protein NDC80 homolog

1

3

High-throughput

0.573

High

868189

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.573

High

1217956

MYOME
Myomegalin

1

4

High-throughput

0.573

High

1242669

NECA2
N-terminal EF-hand calcium-binding protein 2

1

1

High-throughput

0.573

High

1242670

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.573

High

1242704

ABI3
ABI gene family member 3

1

5

High-throughput

0.573

High

1242672

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.549

High

451185

NFL
Neurofilament light polypeptide

1

8

High-throughput

0.541

High

161623

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

2

High-throughput

0.536

High

244165

KIF5C
Kinesin heavy chain isoform 5C

1

20

High-throughput

0.536

High

244853

TRAK2
Trafficking kinesin-binding protein 2

1

19

High-throughput

0.536

High

269777

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

6

High-throughput

0.536

High

271714

HIP1R
Huntingtin-interacting protein 1-related protein

1

3

High-throughput

0.536

High

336446

SVIL
Supervillin

1

1

High-throughput

0.536

High

573844

CCNB1
G2/mitotic-specific cyclin-B1

1

1

High-throughput

0.536

High

659515

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.536

High

682521

S100P
Protein S100-P

1

9

High-throughput

0.536

High

733701

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

2

High-throughput

0.536

High

856748

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.536

High

1025370

CDK6
Cyclin-dependent kinase 6

1

5

High-throughput

0.536

High

1026734

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

3

High-throughput

0.536

High

1087011

KIF5A
Kinesin heavy chain isoform 5A

1

20

High-throughput

0.536

High

1089218

TRI26
Tripartite motif-containing protein 26

1

3

High-throughput

0.536

High

1103051

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

2

High-throughput

0.536

High

1134469

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

High-throughput

0.536

High

1242680

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.536

High

1242681

NGDN
Neuroguidin

1

1

High-throughput

0.536

High

1242687

SH3K1
SH3 domain-containing kinase-binding protein 1

1

4

High-throughput

0.536

High

1242688

DTBP1
Dysbindin

1

2

High-throughput

0.536

High

1242691

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

2

High-throughput

0.536

High

1242692

LYST
Lysosomal-trafficking regulator

1

4

High-throughput

0.536

High

1242706

DAPK2
Death-associated protein kinase 2

1

8

High-throughput

0.536

High

587114

ITF2
Transcription factor 4

1

1

High-throughput

0.523

High

618051

K1C15
Keratin, type I cytoskeletal 15

1

12

High-throughput

0.523

High

1242666

ZN572
Zinc finger protein 572

1

1

High-throughput

0.523

High

1242694

WAC
WW domain-containing adapter protein with coiled-coil

1

2

High-throughput

0.523

High

216720

HTRA2
Serine protease HTRA2, mitochondrial

1

3

High-throughput

0.515

High

274630

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.515

High

374688

RASH
GTPase HRas

1

6

High-throughput

0.515

High

833297

PERI
Peripherin

1

8

High-throughput

0.515

High

248891

GSDME
Gasdermin-E

1

0

High-throughput

0.513

High

320992

SUN1
SUN domain-containing protein 1

1

0

High-throughput

0.513

High

556860

MYH1
Myosin-1

1

0

High-throughput

0.513

High

643501

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.513

High

909441

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.513

High

1214507

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1242678

CB069
Mitochondrial protein C2orf69

1

0

High-throughput

0.513

High

1242685

SYMPK
Symplekin

1

0

High-throughput

0.513

High

1242693

ATP5S
ATP synthase subunit s, mitochondrial

1

0

High-throughput

0.513

High

702462

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

1242686

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

156295

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

1

High-throughput

0.489

High

231489

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.489

High

272691

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

High-throughput

0.489

High

592667

ITB4
Integrin beta-4

1

3

High-throughput

0.489

High

706173

S10A2
Protein S100-A2

1

9

High-throughput

0.489

High

1034686

MEF2A
Myocyte-specific enhancer factor 2A

1

1

High-throughput

0.489

High

1104910

XRCC4
DNA repair protein XRCC4

1

2

High-throughput

0.489

High

1226892

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.489

High

1242703

ARP10
Actin-related protein 10

1

3

High-throughput

0.489

High

1242708

EXO1
Exonuclease 1

1

1

High-throughput

0.489

High

156637

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

5

Small-scale

0.479

High

242028

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

730687

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

1106583

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

1242699

KI13B
Kinesin-like protein KIF13B

1

16

High-throughput

0.479

High

49898

A1A4E9
Keratin 13

1

15

High-throughput

0.470

High

167291

KLF11
Krueppel-like factor 11

1

6

High-throughput

0.470

High

650235

FGFR3
Fibroblast growth factor receptor 3

1

12

High-throughput

0.470

High

1081539

Q0VDC6
peptidylprolyl isomerase

1

3

High-throughput

0.470

High

1242695

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.470

High

1119169

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

246691

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.439

High

566278

K1C13
Keratin, type I cytoskeletal 13

1

15

High-throughput

0.439

High

933851

GEM
GTP-binding protein GEM

1

3

High-throughput

0.439

High

1053457

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

10

High-throughput

0.437

High

1150741

SF01
Splicing factor 1

1

3

High-throughput

0.437

High

1242668

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

4

High-throughput

0.437

High

1242671

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

10

High-throughput

0.437

High

1242709

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.437

High

1242710

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

116348

H3BSK8
RB binding protein 6, ubiquitin ligase

1

1

High-throughput

0.407

High

286672

STX11
Syntaxin-11

1

0

High-throughput

0.299

High

1210060

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.299

High

1234719

CENPP
Centromere protein P

1

0

High-throughput

0.299

High

1242674

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.299

High

1242679

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

1242682

ZN417
Zinc finger protein 417

1

0

High-throughput

0.299

High

1242700

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.299

High

1242702

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.299

High

1086614

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.282

High

133364

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.279

Low

1242665

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.279

Low

1242683

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.279

Low

1242696

BHE41
Class E basic helix-loop-helix protein 41

1

0

High-throughput

0.279

Low

1242705

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.279

Low

1242667

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.268

Low

69383

WASH1
WASH complex subunit 1

1

0

High-throughput

0.251

Low

1242689

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

116491

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low

261199

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025