HitPredict

Interactor 1: Q3ZB59 (Q3ZB59)
Growth factor receptor bound protein 2-associated protein 2
Gene: Gab2

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	10995764, 20697350
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Mm			1 217
+	Mm
		1141175 GAB2_MOUSE (1-665): 2.53e-180: 529: 99.85		GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00
+	Hs
		924959 GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		69824 GAB2_MOUSE (1-665): 2.53e-180: 529: 99.85		B1AT92_MOUSE (1-217): 1.31e-67: 208: 89.86
+	Mm
		639464 GAB2_MOUSE (1-665): 2.53e-180: 529: 99.85		LYN_MOUSE (3-202): 3.06e-38: 140: 27.49
+	Hs
		557834 GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		924547 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		292691 GAB2_MOUSE (1-665): 2.53e-180: 529: 99.85		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74
+	Hs
		1040322 GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82		GRAP_HUMAN (3-57): 2.36e-13: 68: 36.36
+	Hs
		275242 GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82		GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62
+	Hs
		523213 GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		434086 GAB2_HUMAN (4-665): 1.34e-176: 520: 90.82		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		411709 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Hs
		557681 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		548703 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10
+	Hs
		433345 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		442825 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61
+	Hs
		855792 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18
+	Hs
		275195 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62
+	Hs
		522965 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433750 GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39