Protein: DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)

Gene: DYRK4
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q9NR20

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461961

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.847

High

468834

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

1366134

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

17

High-throughput

0.780

High

186588

TRI18
E3 ubiquitin-protein ligase Midline-1

1

12

High-throughput

0.740

High

274772

DNJB6
DnaJ homolog subfamily B member 6

1

7

High-throughput

0.691

High

679266

DNJB1
DnaJ homolog subfamily B member 1

1

8

High-throughput

0.691

High

1038707

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

16

High-throughput

0.691

High

1106086

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

16

High-throughput

0.691

High

1125681

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

16

High-throughput

0.691

High

1158561

CDC37
Hsp90 co-chaperone Cdc37

1

7

High-throughput

0.691

High

1447748

CALL5
Calmodulin-like protein 5

1

4

High-throughput

0.665

High

1145690

RCN1
Reticulocalbin-1

1

8

High-throughput

0.618

High

124508

HAX1
HCLS1-associated protein X-1

2

1

High-throughput

0.558

High

1114394

CUL3
Cullin-3

1

10

High-throughput

0.541

High

124843

AIP
AH receptor-interacting protein

1

12

High-throughput

0.536

High

420712

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

5

High-throughput

0.536

High

731634

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.536

High

895967

F10A1
Hsc70-interacting protein

1

17

High-throughput

0.536

High

907592

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

11

High-throughput

0.536

High

916709

PPP5
Serine/threonine-protein phosphatase 5

1

15

High-throughput

0.536

High

1144179

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.536

High

1421319

WDR33
pre-mRNA 3' end processing protein WDR33

1

12

High-throughput

0.536

High

1447747

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.536

High

1447749

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.536

High

483649

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

813228

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

1403737

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.513

High

1437955

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.513

High

786870

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

14

Small-scale

0.508

High

861796

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

1349771

FBX25
F-box only protein 25

1

2

Small-scale

0.501

High

730910

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

972038

1433E
14-3-3 protein epsilon

1

15

High-throughput

0.479

High

1066511

RBBP4
Histone-binding protein RBBP4

1

7

High-throughput

0.479

High

391479

FRIL
Ferritin light chain

1

3

High-throughput

0.445

High

162283

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025