HitPredict

Interactor 1: ZACN (Q401N2)
Ligand-gated cation channel ZACN (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) (Zinc-activated channel)
Gene: ZACN

Interactor 2: LRC8C (Q8TDW0)
Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C)
Gene: LRRC8C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 803
+	Hs
		798497 ACHA4_HUMAN (29-364): 6.43e-129: 386: 18.10		LRC8E_HUMAN (491-803): 1.09e-30: 131: 19.94
+	Hs
		802362 5HT3A_HUMAN (24-332): 3.32e-125: 372: 24.23		LRC8C_HUMAN (474-803): 2.36e-34: 142: 19.54
+	Hs
		802335 5HT3A_HUMAN (24-332): 3.32e-125: 372: 24.23		LRC8E_HUMAN (491-803): 1.09e-30: 131: 19.94
+	Hs
		798510 ACHA4_HUMAN (29-364): 6.43e-129: 386: 18.10		LRC8D_HUMAN (503-803): 3.02e-19: 95.1: 18.47
+	Hs
		798521 ACHA4_HUMAN (29-364): 6.43e-129: 386: 18.10		LRC8A_HUMAN (571-802): 2.53e-17: 88.9: 18.40
+	Hs
		802342 5HT3A_HUMAN (24-332): 3.32e-125: 372: 24.23		LRC8D_HUMAN (503-803): 3.02e-19: 95.1: 18.47
+	Hs
		1114497 ZACN_HUMAN (1-412): 2.25e-127: 375: 100.00		LRC8A_HUMAN (571-802): 2.53e-17: 88.9: 18.40
+	Hs
		802352 5HT3A_HUMAN (24-332): 3.32e-125: 372: 24.23		LRC8A_HUMAN (571-802): 2.53e-17: 88.9: 18.40
+	Hs
		1219407 5HT3C_HUMAN (20-357): 1.11e-119: 357: 24.01		LRC8A_HUMAN (571-802): 2.53e-17: 88.9: 18.40