HitPredict

Interactor 1: TIGIT (Q495A1)
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
Gene: TIGIT

Interactor 2: NECT3 (Q9NQS3)
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Gene: NECTIN3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	21982860
Identification Methods	pull down, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 244 Hs			1 549
+	Hs
		1115376 TIGIT_HUMAN (1-244): 0: 527: 100.00		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		1078210 TIGIT_HUMAN (1-244): 0: 527: 100.00		CD226_HUMAN (37-208): 2.88e-42: 156: 27.01
+	Hs
		1115379 TIGIT_HUMAN (1-244): 0: 527: 100.00		NECT4_HUMAN (4-263): 2.81e-12: 71.1: 11.03
+	Hs
		545119 TIGIT_HUMAN (1-244): 0: 527: 100.00		PVR_HUMAN (2-269): 4.78e-10: 63.8: 13.33