HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: DVL3 (Q61062)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36417873
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~PDZ_6, PDZ~SAM_1, PDZ~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 716
+	Mm
		844417 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DVL1_MOUSE (1-716): 1.12e-144: 440: 62.69
+	Mm
		1115995 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DLG1_MOUSE (22-656): 1.2e-53: 201: 14.12
+	Mm
		1115938 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DLG4_MOUSE (81-627): 5.07e-49: 185: 13.50
+	Mm
		1116062 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DLG2_MOUSE (54-387): 5.43e-17: 87.3: 14.33
+	Hs
		942399 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		DLG4_HUMAN (81-627): 2.86e-48: 183: 13.14
+	Hs
		150927 RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21		DVL2_HUMAN (3-716): 1.72e-120: 379: 65.03
+	Mm
		1143381 SHAN2_MOUSE (352-1727): 1.03e-90: 328: 35.55		DLG4_MOUSE (81-627): 5.07e-49: 185: 13.50
+	Mm
		103602 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		DLG4_MOUSE (81-627): 5.07e-49: 185: 13.50
+	Mm
		1143380 DAPK1_MOUSE (103-578): 1.89e-68: 257: 13.99		DLG4_MOUSE (81-627): 5.07e-49: 185: 13.50
+	Hs
		862082 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		LNX1_HUMAN (2-331): 9.08e-20: 96.1: 14.75
+	Hs
		280069 TNKS2_HUMAN (1-544): 1.02e-87: 315: 15.16		MPDZ_HUMAN (250-428): 1.91e-12: 73.1: 18.28
+	Hs
		280009 TNKS1_HUMAN (12-400): 2.92e-79: 291: 16.63		MPDZ_HUMAN (250-428): 1.91e-12: 73.1: 18.28
+	Ce
		103468 TTN1_CAEEL (848-1687): 4.79e-55: 215: 13.34		DLG1_CAEEL (105-634): 1.42e-25: 114: 13.82
+	Mm
		88371 SHAN1_MOUSE (367-1725): 5.86e-28: 126: 14.36		DLG4_MOUSE (81-627): 5.07e-49: 185: 13.50
+	Rn
		677807 SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14		DLG4_RAT (81-627): 1.84e-48: 184: 13.14
+	Hs
		1050092 ANR50_HUMAN (197-1044): 5.47e-49: 194: 10.39		SCRIB_HUMAN (240-454): 4.24e-17: 88.3: 17.27
+	Hs
		1256920 KDIS_HUMAN (258-430): 1.28e-21: 105: 16.19		PARD3_HUMAN (44-645): 3.07e-43: 170: 14.22
+	Hs
		1020190 MIB1_HUMAN (187-625): 7.14e-50: 195: 10.66		PTN13_HUMAN (74-379): 3.46e-09: 62.6: 13.23
+	Hs
		942404 SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37		DLG4_HUMAN (81-627): 2.86e-48: 183: 13.14
+	Rn
		1144361 SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14		DLG2_RAT (54-387): 1.44e-16: 86.2: 14.33