Protein: DOCK6
Dedicator of cytokinesis protein 6

Gene: DOCK6
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q96HP0

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007264 - small GTPase-mediated signal transduction
GO:0035023 - regulation of Rho protein signal transduction
GO:0048471 - perinuclear region of cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1338508

DOCK8
Dedicator of cytokinesis protein 8

3

11

High-throughput

0.871

High

1393341

DOCK7
Dedicator of cytokinesis protein 7

3

11

High-throughput

0.861

High

1393340

LRCH3
DISP complex protein LRCH3

6

12

High-throughput

0.730

High

1116379

RAB32
Ras-related protein Rab-32

1

5

High-throughput

0.691

High

956445

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.656

High

1273120

MOB1B
MOB kinase activator 1B

2

11

High-throughput

0.621

High

1393344

MOB1A
MOB kinase activator 1A

2

11

High-throughput

0.621

High

1393347

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

4

12

High-throughput

0.619

High

901483

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.618

High

988608

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

69816

ZN785
Zinc finger protein 785

2

2

High-throughput

0.574

High

128294

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

0

High-throughput

0.547

High

187774

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

0

High-throughput

0.547

High

1393349

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

2

0

High-throughput

0.547

High

281536

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

2

12

High-throughput

0.543

High

563028

MYH6
Myosin-6

1

1

High-throughput

0.536

High

1178618

KIF7
Kinesin-like protein KIF7

1

1

High-throughput

0.536

High

1307698

CRLF3
Cytokine receptor-like factor 3

1

2

High-throughput

0.536

High

1383808

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

292923

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.513

High

533735

CLUS
Clusterin

1

0

High-throughput

0.513

High

1218060

CBPC6
Cytosolic carboxypeptidase 6

1

0

High-throughput

0.513

High

1393342

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

508440

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

1125384

FLNC
Filamin-C

1

0

High-throughput

0.493

High

228739

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.489

High

1233176

ISM2
Isthmin-2

1

1

High-throughput

0.489

High

1393345

RTN4
Reticulon-4

1

2

High-throughput

0.489

High

173226

XPO1
Exportin-1

1

4

High-throughput

0.479

High

905030

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

1049662

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1106656

SMAD4
Mothers against decapentaplegic homolog 4

1

4

High-throughput

0.479

High

1115906

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.479

High

1135046

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1310778

CUL9
Cullin-9

1

3

High-throughput

0.479

High

1393348

HYOU1
Hypoxia up-regulated protein 1

1

2

High-throughput

0.470

High

655302

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.458

High

1352888

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

765794

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

471185

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.437

High

481361

HMGB1
High mobility group protein B1

1

2

High-throughput

0.437

High

1218305

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

12

High-throughput

0.437

High

1250186

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.437

High

1255064

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1258367

MOB3C
MOB kinase activator 3C

1

11

High-throughput

0.437

High

1393343

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.437

High

255164

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

1393346

ZN331
Zinc finger protein 331

2

0

High-throughput

0.328

High

522477

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

0

High-throughput

0.298

High

133563

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.279

Low

1027133

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1120577

LRP8
Low-density lipoprotein receptor-related protein 8

1

0

High-throughput

0.279

Low

1181529

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

0

High-throughput

0.269

Low

256355

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.249

Low

279458

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

283531

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025