Protein: DOCK7
Dedicator of cytokinesis protein 7

Gene: DOCK7
Organism: Homo sapiens
Interactions: 237
UniProt ID: Q96N67

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005925 - focal adhesion
GO:0007409 - axonogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1338511

DOCK8
Dedicator of cytokinesis protein 8

7

11

High-throughput

0.965

High

1393341

DOCK6
Dedicator of cytokinesis protein 6

3

11

High-throughput

0.861

High

955485

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.806

High

988617

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.806

High

1394185

LRCH3
DISP complex protein LRCH3

8

12

High-throughput

0.687

High

1398868

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

7

12

High-throughput

0.682

High

966758

1433G
14-3-3 protein gamma

3

20

High-throughput

0.675

High

179554

ARPC3
Actin-related protein 2/3 complex subunit 3

3

1

High-throughput

0.667

High

990616

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.667

High

730155

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.650

High

1398863

MYO6
Unconventional myosin-VI

4

3

Small-scale

0.644

High

346209

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

1

High-throughput

0.640

High

1273123

MOB1B
MOB kinase activator 1B

4

11

High-throughput

0.638

High

1049675

1433F
14-3-3 protein eta

4

20

High-throughput

0.638

High

971890

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.635

High

1218309

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

4

12

High-throughput

0.633

High

281538

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

4

12

High-throughput

0.626

High

126747

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

375847

RASK
GTPase KRas

1

14

High-throughput

0.618

High

978229

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1145061

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.618

High

1398843

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

277468

AVIL
Advillin

2

0

High-throughput

0.602

High

242630

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

1398853

TMOD3
Tropomodulin-3

2

1

High-throughput

0.574

High

372875

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.571

High

1280010

RHG30
Rho GTPase-activating protein 30

2

4

High-throughput

0.571

High

1398859

FBW1B
F-box/WD repeat-containing protein 11

2

3

High-throughput

0.571

High

1398841

MOB1A
MOB kinase activator 1A

2

11

High-throughput

0.558

High

374143

RASN
GTPase NRas

1

13

High-throughput

0.553

High

123806

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.536

High

328981

RTN3
Reticulon-3

1

2

High-throughput

0.536

High

347261

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

606025

CAN2
Calpain-2 catalytic subunit

1

4

High-throughput

0.536

High

772965

MYH9
Myosin-9

1

1

High-throughput

0.536

High

783644

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

High-throughput

0.536

High

1384107

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

1396674

MARK4
MAP/microtubule affinity-regulating kinase 4

1

1

High-throughput

0.536

High

1398846

RTN4
Reticulon-4

1

2

High-throughput

0.536

High

872645

SOX2
Transcription factor SOX-2

2

1

High-throughput

0.533

High

411008

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

Small-scale

0.528

High

553264

KCRB
Creatine kinase B-type

2

1

High-throughput

0.521

High

566806

PDIA4
Protein disulfide-isomerase A4

2

2

High-throughput

0.521

High

571501

GLU2B
Glucosidase 2 subunit beta

2

1

High-throughput

0.521

High

647628

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

1

High-throughput

0.521

High

1126637

GRB7
Growth factor receptor-bound protein 7

1

13

High-throughput

0.508

High

1253158

NBEL2
Neurobeachin-like protein 2

1

2

High-throughput

0.506

High

564232

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.504

High

1380823

TRI63
E3 ubiquitin-protein ligase TRIM63

1

9

High-throughput

0.494

High

1398830

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.494

High

69819

ZN785
Zinc finger protein 785

1

2

High-throughput

0.489

High

220101

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.489

High

295621

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.489

High

322984

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

High-throughput

0.489

High

625571

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.489

High

682580

S100P
Protein S100-P

1

5

High-throughput

0.489

High

765808

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.489

High

854235

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.489

High

868758

LEG7
Galectin-7

1

1

High-throughput

0.489

High

920494

DAPK1
Death-associated protein kinase 1

1

3

High-throughput

0.489

High

964711

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.489

High

1233177

ISM2
Isthmin-2

1

1

High-throughput

0.489

High

1254137

CAN12
Calpain-12

1

2

High-throughput

0.489

High

1307701

CRLF3
Cytokine receptor-like factor 3

1

2

High-throughput

0.489

High

1371611

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.489

High

1383813

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.489

High

1392652

MYO19
Unconventional myosin-XIX

1

4

High-throughput

0.489

High

1397626

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1398822

TCPQM
T-complex protein 1 subunit theta-like 2

1

5

High-throughput

0.489

High

1398823

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1398837

TXNIP
Thioredoxin-interacting protein

1

2

High-throughput

0.489

High

1398842

PKHA1
Pleckstrin homology domain-containing family A member 1

1

3

High-throughput

0.489

High

1398845

CAN10
Calpain-10

1

2

High-throughput

0.489

High

1398866

AKT3
RAC-gamma serine/threonine-protein kinase

1

3

High-throughput

0.489

High

791638

SYUA
Alpha-synuclein

1

0

High-throughput

0.486

High

1160552

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

173244

XPO1
Exportin-1

1

4

High-throughput

0.479

High

252477

DIAP1
Protein diaphanous homolog 1

1

1

High-throughput

0.479

High

401320

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

412452

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

459721

PROF1
Profilin-1

1

3

High-throughput

0.479

High

463710

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.479

High

643031

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

691341

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

845760

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.479

High

891289

GSK3A
Glycogen synthase kinase-3 alpha

1

5

High-throughput

0.479

High

891744

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.479

High

1035850

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1091446

ANK3
Ankyrin-3

1

2

High-throughput

0.479

High

1115920

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.479

High

1253229

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

5

High-throughput

0.479

High

1398821

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

1398856

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.479

High

1258370

MOB3C
MOB kinase activator 3C

1

11

High-throughput

0.470

High

1364971

TSC1
Hamartin

1

6

Small-scale

0.470

High

628008

ANXA7
Annexin A7

1

4

High-throughput

0.464

High

977568

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

1

High-throughput

0.464

High

319988

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

582926

EZRI
Ezrin

1

0

High-throughput

0.458

High

612741

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

898519

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

975181

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

995773

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1398825

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.458

High

1398828

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

1398836

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1398867

RP3A
Rabphilin-3A

1

0

High-throughput

0.458

High

175166

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.457

High

255171

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

516574

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

537731

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.445

High

1227285

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

106489

APRIO
Alternative prion protein

1

1

Small-scale

0.439

High

1398849

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

136122

PLK4
Serine/threonine-protein kinase PLK4

1

7

High-throughput

0.437

High

170293

AURKA
Aurora kinase A

1

5

High-throughput

0.437

High

323536

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.437

High

437306

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.437

High

451052

LDHB
L-lactate dehydrogenase B chain

1

3

High-throughput

0.437

High

487645

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.437

High

641656

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

Small-scale

0.437

High

730832

1433S
14-3-3 protein sigma

1

20

High-throughput

0.437

High

828903

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

831261

CCNF
Cyclin-F

1

2

High-throughput

0.437

High

905047

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

920205

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.437

High

930018

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

941831

ARL4C
ADP-ribosylation factor-like protein 4C

1

3

High-throughput

0.437

High

970936

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1067612

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

1109997

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.437

High

1114041

CUL3
Cullin-3

1

5

High-throughput

0.437

High

1115006

CUL4A
Cullin-4A

1

5

High-throughput

0.437

High

1137953

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

1140709

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

1197543

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.437

High

1250189

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.437

High

1255122

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1276657

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1287072

MOB3B
MOB kinase activator 3B

1

11

High-throughput

0.437

High

1292799

SKAP1
Src kinase-associated phosphoprotein 1

1

11

High-throughput

0.437

High

1338473

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

1

High-throughput

0.437

High

1360801

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.437

High

1367053

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1380092

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.437

High

1381936

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1384411

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

1391710

AURKB
Aurora kinase B

1

5

High-throughput

0.437

High

1398826

DUS26
Dual specificity protein phosphatase 26

1

2

High-throughput

0.437

High

1398827

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.437

High

1398835

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.437

High

1398848

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.437

High

1398850

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.437

High

1398852

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.437

High

1398855

PD1L1
Programmed cell death 1 ligand 1

1

3

Small-scale

0.437

High

1398857

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

1398858

DS13B
Dual specificity protein phosphatase 13B

1

2

High-throughput

0.437

High

1398860

RCOR1
REST corepressor 1

1

1

High-throughput

0.437

High

1398861

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.437

High

1398864

ALK
ALK tyrosine kinase receptor

1

6

High-throughput

0.437

High

1398871

NEMO
NF-kappa-B essential modulator

1

5

Small-scale

0.437

High

422920

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.426

High

1110538

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.426

High

1209529

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

516445

CALM2
Calmodulin-2

1

1

High-throughput

0.407

High

839071

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.407

High

1066001

VAC14
Protein VAC14 homolog

1

3

High-throughput

0.407

High

1243516

CSAG1
Chondrosarcoma-associated gene 1 protein

1

3

High-throughput

0.407

High

1398824

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.407

High

1398838

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.407

High

1398870

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

3

High-throughput

0.407

High

845470

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

0

High-throughput

0.347

High

1398851

PIHD1
PIH1 domain-containing protein 1

3

0

High-throughput

0.347

High

1054631

PSME1
Proteasome activator complex subunit 1

2

0

High-throughput

0.313

High

808146

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

High-throughput

0.313

High

1398844

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

Small-scale

0.299

High

935022

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.298

High

1158964

RBBP7
Histone-binding protein RBBP7

2

0

High-throughput

0.298

High

1398834

API5
Apoptosis inhibitor 5

2

0

High-throughput

0.298

High

66516

RASFA
Ras association domain-containing protein 10

1

0

High-throughput

0.279

Low

216787

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.279

Low

240114

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

0

High-throughput

0.279

Low

277395

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.279

Low

296815

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

354031

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

570961

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.279

Low

573872

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.279

Low

667992

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.279

Low

866791

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

867354

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

983942

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.279

Low

1064591

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.279

Low

1092809

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1129178

IRF3
Interferon regulatory factor 3

1

0

High-throughput

0.279

Low

1207250

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1325825

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1337754

KLDC9
Kelch domain-containing protein 9

1

0

High-throughput

0.279

Low

1388081

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1398832

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

1398833

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1398839

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1398840

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.279

Low

1398862

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

1398869

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.279

Low

325445

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.265

Low

405530

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

1060208

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.265

Low

1398831

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.265

Low

1398829

RNF26
E3 ubiquitin-protein ligase RNF26

1

0

Small-scale

0.261

Low

246872

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

248046

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

291496

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

294198

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

414431

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

589446

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

827466

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.249

Low

884385

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.249

Low

913262

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.249

Low

1004990

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1024772

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1045656

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1161604

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.249

Low

1239731

PPR18
Phostensin

1

0

High-throughput

0.249

Low

1250898

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low

1339662

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1357519

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1364524

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

1386768

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.249

Low

1398820

TSNA1
t-SNARE domain-containing protein 1

1

0

High-throughput

0.249

Low

1398847

ANLN
Anillin

1

0

High-throughput

0.249

Low

1398854

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

1398865

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.249

Low

653513

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1094402

CSN1
COP9 signalosome complex subunit 1

1

0

High-throughput

0.232

Low

1103325

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low

1104061

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1370308

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025