HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: ARHG7 (Q9ES28)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)
Gene: Arhgef7

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27507650
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ_6~betaPIX_CC, SH3_2~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 862
+	Hs
		1049728 SHAN3_HUMAN (1-1730): 0: 601: 95.21		ARHG7_HUMAN (1-772): 0: 606: 91.68
+	Rn
		223053 SHAN3_RAT (1-1730): 0: 618: 98.39		ARHG7_RAT (158-862): 4.97e-150: 457: 86.81
+	Hs
		1049744 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		ARHG7_HUMAN (1-772): 0: 606: 91.68
+	Mm
		1115909 SHAN3_MOUSE (1-1730): 0: 626: 100.00		SPT13_MOUSE (95-638): 1.48e-96: 318: 20.35
+	Hs
		1078902 SHAN3_HUMAN (1-1730): 0: 601: 95.21		ITSN1_HUMAN (100-583): 2.53e-78: 280: 17.54
+	Mm
		57847 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KALRN_MOUSE (113-643): 2.08e-66: 244: 14.23
+	Rn
		223054 SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92		ARHG7_RAT (158-862): 4.97e-150: 457: 86.81
+	Hs
		1049748 SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37		ARHG7_HUMAN (1-772): 0: 606: 91.68
+	Hs
		1239491 ANR52_HUMAN (14-494): 3.38e-78: 284: 16.60		ARHG2_HUMAN (96-860): 1.16e-91: 312: 13.17
+	Rn
		223055 SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14		ARHG7_RAT (158-862): 4.97e-150: 457: 86.81
+	Hs
		1021479 ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01		FARP1_HUMAN (204-604): 1.29e-90: 311: 22.07
+	Hs
		1330900 Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21		FARP1_HUMAN (204-604): 1.29e-90: 311: 22.07
+	Hs
		883686 RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21		FARP1_HUMAN (204-604): 1.29e-90: 311: 22.07
+	Hs
		166988 ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60		ARHG2_HUMAN (96-860): 1.16e-91: 312: 13.17
+	Hs
		1078859 MIB1_HUMAN (187-625): 7.14e-50: 195: 10.66		ITSN1_HUMAN (100-583): 2.53e-78: 280: 17.54
+	Hs
		167038 ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60		PKHG1_HUMAN (214-811): 3.41e-85: 299: 19.94
+	Hs
		965179 ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64		FARP1_HUMAN (204-604): 1.29e-90: 311: 22.07
+	Hs
		1021392 ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01		TIAM1_HUMAN (217-435): 6.56e-12: 71.6: 26.16
+	Mm
		57869 ANK2_MOUSE (134-335): 6.85e-09: 63.5: 31.19		KALRN_MOUSE (113-643): 2.08e-66: 244: 14.23
+	Hs
		556699 ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35		TIAM1_HUMAN (217-435): 6.56e-12: 71.6: 26.16