HitPredict

Interactor 1: KLH22 (Q53GT1)
Kelch-like protein 22
Gene: KLHL22

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	19615732, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 634 Hs			1 327
+	Hs
		1120774 KLH12_HUMAN (30-594): 7.74e-153: 454: 25.18		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184943 KLH15_HUMAN (29-603): 8.9e-82: 271: 30.54		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1185018 KLH20_HUMAN (380-633): 2.47e-67: 232: 21.09		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184998 KLHL8_HUMAN (446-633): 3.96e-39: 154: 19.05		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1153783 KLH10_HUMAN (448-633): 1.27e-38: 153: 18.18		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		299521 KLH18_HUMAN (474-634): 1.53e-31: 131: 16.67		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1121474 KLH26_HUMAN (378-633): 3.87e-23: 106: 16.30		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184911 KLH23_HUMAN (494-631): 3.21e-23: 106: 23.74		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1164611 KLH24_HUMAN (269-446): 1.01e-16: 85.7: 20.11		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184999 KLHL9_HUMAN (546-633): 4.32e-10: 64.9: 12.50		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1185001 KLH13_HUMAN (546-633): 8.97e-10: 63.7: 12.50		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00