Protein: TRI18
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)

Gene: TRI18, MID1
Organism: Homo sapiens
Interactions: 122
UniProt ID: O15344

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005819 - spindle
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186488

TRI18
E3 ubiquitin-protein ligase Midline-1

13

19

Small-scale

0.981

High

186519

UB2D1
Ubiquitin-conjugating enzyme E2 D1

10

20

Small-scale

0.981

High

186524

UB2D3
Ubiquitin-conjugating enzyme E2 D3

10

20

Small-scale

0.978

High

186596

TRIM1
Probable E3 ubiquitin-protein ligase MID2

9

20

Small-scale

0.978

High

186530

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.967

High

186570

UB2E3
Ubiquitin-conjugating enzyme E2 E3

6

20

Small-scale

0.951

High

186520

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

20

Small-scale

0.870

High

186577

UB2E2
Ubiquitin-conjugating enzyme E2 E2

7

20

Small-scale

0.865

High

186534

UB2L3
Ubiquitin-conjugating enzyme E2 L3

3

20

High-throughput

0.861

High

186525

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

High-throughput

0.845

High

186526

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.821

High

186498

IL6RA
Interleukin-6 receptor subunit alpha

2

17

High-throughput

0.811

High

186584

ZFYV1
Zinc finger FYVE domain-containing protein 1

2

20

High-throughput

0.811

High

186599

UB2D4
Ubiquitin-conjugating enzyme E2 D4

4

20

Small-scale

0.801

High

168470

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

2

20

High-throughput

0.783

High

186582

UBTD1
Ubiquitin domain-containing protein 1

3

5

High-throughput

0.779

High

186538

IGBP1
Immunoglobulin-binding protein 1

14

2

Small-scale

0.761

High

186531

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

10

High-throughput

0.754

High

186593

TBA8
Tubulin alpha-8 chain

2

20

High-throughput

0.754

High

186550

PKN1
Serine/threonine-protein kinase N1

1

15

High-throughput

0.740

High

186588

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

12

High-throughput

0.740

High

186590

STK36
Serine/threonine-protein kinase 36

1

9

Small-scale

0.724

High

186541

Q0VDC6
peptidylprolyl isomerase

2

11

High-throughput

0.706

High

186543

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

186571

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

186517

MEOX1
Homeobox protein MOX-1

3

20

High-throughput

0.683

High

186575

GMCL1
Germ cell-less protein-like 1

5

20

High-throughput

0.655

High

186540

ECHP
Peroxisomal bifunctional enzyme

3

16

High-throughput

0.654

High

186533

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

12

Small-scale

0.651

High

186549

PTPA
Serine/threonine-protein phosphatase 2A activator

3

1

Small-scale

0.647

High

186493

STBD1
Starch-binding domain-containing protein 1

3

0

High-throughput

0.638

High

186581

EPN3
Epsin-3

4

16

High-throughput

0.634

High

74318

ZBT42
Zinc finger and BTB domain-containing protein 42

2

20

High-throughput

0.628

High

186491

GEMI
Geminin

2

2

High-throughput

0.628

High

186513

GSTT1
Glutathione S-transferase theta-1

2

2

High-throughput

0.628

High

186521

AF17
Protein AF-17

2

5

High-throughput

0.628

High

186545

BYST
Bystin

2

7

High-throughput

0.628

High

51378

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

20

High-throughput

0.618

High

186585

LRRC4
Leucine-rich repeat-containing protein 4

1

7

High-throughput

0.618

High

181762

EPHB6
Ephrin type-B receptor 6

1

17

High-throughput

0.618

High

186496

TBB5
Tubulin beta chain

1

20

Small-scale

0.618

High

186499

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

18

Small-scale

0.618

High

186503

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

17

Small-scale

0.618

High

186532

RACK1
Small ribosomal subunit protein RACK1

1

12

Small-scale

0.618

High

186536

TBA1B
Tubulin alpha-1B chain

1

20

Small-scale

0.618

High

186537

TBB4B
Tubulin beta-4B chain

1

20

Small-scale

0.618

High

186558

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

186565

LNX1
E3 ubiquitin-protein ligase LNX

1

18

Small-scale

0.618

High

186569

ESR2
Estrogen receptor beta

1

18

High-throughput

0.618

High

186573

PDLI5
PDZ and LIM domain protein 5

1

20

Small-scale

0.618

High

186580

TRI55
Tripartite motif-containing protein 55

1

18

High-throughput

0.618

High

186586

M1IP1
Mid1-interacting protein 1

2

2

Small-scale

0.611

High

186490

N4BP1
NEDD4-binding protein 1

2

5

High-throughput

0.606

High

186492

EPN2
Epsin-2

2

11

High-throughput

0.606

High

186551

CDC37
Hsp90 co-chaperone Cdc37

2

3

High-throughput

0.606

High

186557

ZN618
Zinc finger protein 618

2

11

High-throughput

0.606

High

186583

KIF9
Kinesin-like protein KIF9

2

20

High-throughput

0.606

High

186500

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.590

High

186512

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

8

Small-scale

0.584

High

186554

CRY2
Cryptochrome-2

2

0

High-throughput

0.580

High

186556

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

16

High-throughput

0.575

High

186507

PAX6
Paired box protein Pax-6

1

4

Small-scale

0.561

High

186514

PPM1A
Protein phosphatase 1A

1

3

Small-scale

0.561

High

186578

SPAG5
Sperm-associated antigen 5

1

20

Small-scale

0.561

High

186587

RIC8A
Chaperone Ric-8A

1

1

Small-scale

0.561

High

186546

ELOA1
Elongin-A

2

13

High-throughput

0.553

High

186567

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

2

High-throughput

0.553

High

186598

FA50B
Protein FAM50B

2

5

High-throughput

0.553

High

186511

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.553

High

186535

EF1A1
Elongation factor 1-alpha 1

1

7

Small-scale

0.552

High

186501

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

3

High-throughput

0.536

High

186522

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

14

High-throughput

0.536

High

186539

IRF8
Interferon regulatory factor 8

1

15

High-throughput

0.536

High

186552

VATF
V-type proton ATPase subunit F

1

1

High-throughput

0.536

High

186563

EIF1A
Probable RNA-binding protein EIF1AD

1

1

High-throughput

0.536

High

186564

ZN784
Zinc finger protein 784

1

20

High-throughput

0.536

High

186591

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

4

High-throughput

0.536

High

186600

SAR1B
Small COPII coat GTPase SAR1B

1

17

High-throughput

0.536

High

75504

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

186594

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

15

Small-scale

0.528

High

186562

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

1

19

High-throughput

0.523

High

186572

OTUB2
Ubiquitin thioesterase OTUB2

1

14

High-throughput

0.523

High

116888

I6L9I8
EPN3 protein

1

9

High-throughput

0.515

High

49502

TLDC2
TLD domain-containing protein 2

1

4

High-throughput

0.489

High

186566

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

3

High-throughput

0.489

High

186592

CARF
CDKN2A-interacting protein

1

3

High-throughput

0.489

High

186597

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.489

High

137866

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

16

Small-scale

0.479

High

186489

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

6

Small-scale

0.479

High

186494

NPM
Nucleophosmin

1

5

Small-scale

0.479

High

186495

ANXA2
Annexin A2

1

14

Small-scale

0.479

High

186497

HS90A
Heat shock protein HSP 90-alpha

1

14

Small-scale

0.479

High

186502

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

186504

PSB1
Proteasome subunit beta type-1

1

20

Small-scale

0.479

High

186505

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.479

High

186506

PSA1
Proteasome subunit alpha type-1

1

18

Small-scale

0.479

High

186508

PSB4
Proteasome subunit beta type-4

1

20

Small-scale

0.479

High

186509

PSB6
Proteasome subunit beta type-6

1

20

Small-scale

0.479

High

186510

PSB5
Proteasome subunit beta type-5

1

17

Small-scale

0.479

High

186515

PRS7
26S proteasome regulatory subunit 7

1

17

Small-scale

0.479

High

186518

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

14

Small-scale

0.479

High

186523

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.479

High

186527

PRS4
26S proteasome regulatory subunit 4

1

16

Small-scale

0.479

High

186528

RS8
Small ribosomal subunit protein eS8

1

3

Small-scale

0.479

High

186529

PRS10
26S proteasome regulatory subunit 10B

1

20

Small-scale

0.479

High

186542

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

9

Small-scale

0.479

High

186544

CUL3
Cullin-3

1

20

High-throughput

0.479

High

186547

IRF3
Interferon regulatory factor 3

1

15

Small-scale

0.479

High

186548

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

186559

ZN598
E3 ubiquitin-protein ligase ZNF598

1

13

High-throughput

0.479

High

186560

GRP3
Ras guanyl-releasing protein 3

1

3

Small-scale

0.479

High

186568

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

18

High-throughput

0.479

High

186574

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

186595

XPO7
Exportin-7

1

16

High-throughput

0.479

High

186555

Q53SE7
Germ cell-less homolog 1

1

20

High-throughput

0.470

High

186579

ATGA1
Autophagy-related protein 101

1

0

Small-scale

0.458

High

186589

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

186516

INAR2
Interferon alpha/beta receptor 2

1

3

Small-scale

0.437

High

186553

MIC60
MICOS complex subunit MIC60

1

1

Small-scale

0.437

High

186576

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

186561

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025