HitPredict

Interactor 1: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Interactor 2: M3K4 (Q9Y6R4)
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)
Gene: MAP3K4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 1608
+	Hs
		892148 ACTB_HUMAN (3-376): 0: 596: 91.71		M3K4_HUMAN (1-1608): 0: 2122: 100.00
+	Hs
		930075 ACTG_HUMAN (3-376): 0: 595: 91.44		M3K4_HUMAN (1-1608): 0: 2122: 100.00
+	Hs
		915545 ACTA_HUMAN (1-376): 0: 588: 87.80		M3K4_HUMAN (1-1608): 0: 2122: 100.00
+	Hs
		566342 ACTB_HUMAN (3-376): 0: 596: 91.71		KPCA_HUMAN (1072-1608): 1.61e-131: 426: 16.45
+	Hs
		566351 ACTG_HUMAN (3-376): 0: 595: 91.44		KPCA_HUMAN (1072-1608): 1.61e-131: 426: 16.45
+	Hs
		408595 ACTS_HUMAN (2-376): 0: 590: 87.47		KPCB_HUMAN (1072-1608): 5.02e-126: 411: 17.12
+	Dm
		862563 ACT3_DROME (1-376): 0: 596: 88.83		AKT1_DROME (1117-1608): 6.61e-118: 386: 18.13
+	Hs
		929982 ACTG_HUMAN (3-376): 0: 595: 91.44		M3K3_HUMAN (1127-1600): 1.93e-112: 372: 27.24
+	Sc
		863043 ACT_YEAST (1-376): 0: 585: 82.98		SSK2_YEAST (1299-1596): 2.09e-54: 212: 35.93