Protein: IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappaB kinase subunit beta) (EC 2.7.11.10) (Cactus kinase IKK) (IKK-like protein) (Immune response deficient protein 5) (Lipopolysaccharide-activated kinase) (DLAK)

Gene: IKKB, IKKbeta
Organism: Drosophila melanogaster
Interactions: 174
UniProt ID: Q9VEZ5

Gene Ontology (top 5):
GO:0002230 - positive regulation of defense response to virus by host
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1374931

NFKB1
Nuclear factor NF-kappa-B p110 subunit

4

20

Small-scale

0.886

High

1040530

CACT
NF-kappa-B inhibitor cactus

2

20

Small-scale

0.825

High

1473370

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

3

20

Small-scale

0.805

High

1473389

Q9VPY3
Charon

2

0

High-throughput

0.699

High

1428057

NEMO
NF-kappa-B essential modulator

5

0

Small-scale

0.683

High

834825

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

1

High-throughput

0.618

High

1465875

ANLN
Anillin

1

2

High-throughput

0.618

High

1470149

ANKHM
Ankyrin repeat and KH domain-containing protein mask

1

2

High-throughput

0.618

High

1473420

RHGF
Rho GTPase-activating protein Graf

1

5

High-throughput

0.618

High

561593

SPTCA
Spectrin alpha chain

1

7

High-throughput

0.553

High

1044932

NONA
Protein no-on-transient A

1

6

High-throughput

0.553

High

1463379

Q9V3E7
LD24793p

1

3

High-throughput

0.553

High

1473381

Q9VJJ9
FI20237p1

1

2

High-throughput

0.553

High

1473421

X2JFU3
Uncharacterized protein, isoform E

1

4

High-throughput

0.553

High

121571

M9PFI0
CCR4-NOT transcription complex subunit 4

1

0

High-throughput

0.517

High

1473373

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.517

High

57843

A1ZB77
Uncharacterized protein, isoform J

1

2

High-throughput

0.479

High

119967

M9PBW9
Rhea, isoform G

1

17

High-throughput

0.479

High

121931

M9PGZ8
Smrter, isoform G

1

20

High-throughput

0.479

High

146142

CH60A
Heat shock protein 60A

1

13

High-throughput

0.479

High

234493

CTBP
C-terminal-binding protein

1

3

High-throughput

0.479

High

264616

KPYK
Pyruvate kinase

1

2

High-throughput

0.479

High

356070

EF1B
Probable elongation factor 1-beta

1

3

High-throughput

0.479

High

356621

HSP68
Heat shock protein 68

1

16

High-throughput

0.479

High

391847

HSP71
Major heat shock 70 kDa protein Ab

1

16

High-throughput

0.479

High

415066

CYC1
Cytochrome c-1

1

1

High-throughput

0.479

High

444098

TBA1
Tubulin alpha-1 chain

1

17

High-throughput

0.479

High

444127

TBA2
Tubulin alpha-2 chain

1

17

High-throughput

0.479

High

444152

TBA3
Tubulin alpha-3 chain

1

19

High-throughput

0.479

High

475825

EF1A1
Elongation factor 1-alpha 1

1

8

High-throughput

0.479

High

476483

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.479

High

538267

HSP7D
Heat shock 70 kDa protein cognate 4

1

14

High-throughput

0.479

High

554097

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.479

High

559822

EF2
Eukaryotic translation elongation factor 2

1

2

High-throughput

0.479

High

565026

ATNA
Sodium/potassium-transporting ATPase subunit alpha

1

2

High-throughput

0.479

High

583391

DORS
Embryonic polarity protein dorsal

1

20

High-throughput

0.479

High

604354

CATA
Catalase

1

1

High-throughput

0.479

High

633077

NCD
Protein claret segregational

1

7

High-throughput

0.479

High

638762

FOSLA
Transcription factor kayak, isoforms A/B/F

1

6

High-throughput

0.479

High

652090

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

1

3

High-throughput

0.479

High

654889

MA205
205 kDa microtubule-associated protein

1

1

High-throughput

0.479

High

663992

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

715345

HSP7A
Heat shock 70 kDa protein cognate 1

1

13

High-throughput

0.479

High

715373

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

715407

HSP7E
Heat shock 70 kDa protein cognate 5

1

20

High-throughput

0.479

High

723845

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

770972

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

852512

CADF
Cofilin/actin-depolymerizing factor homolog

1

6

High-throughput

0.479

High

856451

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

875278

TCPG
T-complex protein 1 subunit gamma

1

16

High-throughput

0.479

High

963929

TBB2
Tubulin beta-2 chain

1

20

High-throughput

0.479

High

1019555

MIC60
MICOS complex subunit Mic60

1

19

High-throughput

0.479

High

1050777

EYA
Protein phosphatase eya

1

3

Small-scale

0.479

High

1052461

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.479

High

1173948

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

2

High-throughput

0.479

High

1174374

CP190
Centrosome-associated zinc finger protein Cp190

1

6

High-throughput

0.479

High

1174609

TBB1
Tubulin beta-1 chain

1

20

High-throughput

0.479

High

1176585

NLP
Nucleoplasmin-like protein

1

3

High-throughput

0.479

High

1264038

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.479

High

1265825

Q7K3J0
T-complex protein 1 subunit theta

1

20

High-throughput

0.479

High

1266888

Q7K581
SD01637p

1

3

High-throughput

0.479

High

1267259

Q7KKI0
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.479

High

1267717

Q7KMQ0
26S proteasome regulatory subunit 7

1

5

High-throughput

0.479

High

1269478

Q7KTW5
Inositol-1-monophosphatase

1

2

High-throughput

0.479

High

1285545

Q86BB4
Transforming acidic coiled-coil protein, isoform E

1

1

High-throughput

0.479

High

1285704

Q86BM5
A kinase anchor protein 200, isoform D

1

3

High-throughput

0.479

High

1286186

LIG
Protein lingerer

1

7

High-throughput

0.479

High

1303867

HSP72
Major heat shock 70 kDa protein Ba

1

16

High-throughput

0.479

High

1321345

LVA
Protein lava lamp

1

20

High-throughput

0.479

High

1463932

RUVB2
RuvB-like helicase 2

1

8

High-throughput

0.479

High

1464043

PRDX2
Peroxiredoxin 2

1

2

High-throughput

0.479

High

1473016

Q9VEN9
Protein associated with topo II related - 1, isoform A

1

3

High-throughput

0.479

High

1473374

HSP74
Major heat shock 70 kDa protein Bbb

1

16

High-throughput

0.479

High

1473376

RUVB1
RuvB-like helicase 1

1

8

High-throughput

0.479

High

1473378

Q9VHL2
T-complex protein 1 subunit eta

1

20

High-throughput

0.479

High

1473383

SOYB
Putative ATP-dependent RNA helicase SoYb

1

7

High-throughput

0.479

High

1473385

CH60C
60 kDa heat shock protein homolog 2, mitochondrial

1

13

High-throughput

0.479

High

1473387

Q9VP57
LD15904p

1

2

High-throughput

0.479

High

1473388

Q9VPU7
Arouser, isoform C

1

19

High-throughput

0.479

High

1473390

Q9VRL8
Blanks

1

3

High-throughput

0.479

High

1473393

FRL
Formin-like protein

1

1

High-throughput

0.479

High

1473394

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1473395

Q9VUU7
Zinc finger protein 706

1

1

High-throughput

0.479

High

1473396

Q9VUU8
Zinc finger protein 706

1

1

High-throughput

0.479

High

1473400

CREBB
Cyclic AMP response element-binding protein B

1

2

High-throughput

0.479

High

1473401

NU153
Nuclear pore complex protein Nup153

1

15

High-throughput

0.479

High

1473402

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

14

High-throughput

0.479

High

1473403

Q9VY76
AMP deaminase

1

1

High-throughput

0.479

High

1473409

Q9W1H5
Decapping protein 1, isoform A

1

1

High-throughput

0.479

High

1473414

Q9W2U7
LP18708p

1

8

High-throughput

0.479

High

1473416

Q9W392
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

95307

E1JIM0
Non-specific lethal 1, isoform E

1

0

High-throughput

0.458

High

628962

OTE
Otefin

1

0

High-throughput

0.458

High

963872

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

1262301

Q7JVK8
GEO08987p1

1

0

High-throughput

0.458

High

1265663

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.458

High

1266341

DGT5
Augmin complex subunit dgt5

1

0

High-throughput

0.458

High

1304436

Q8IP79
ethanolamine-phosphate cytidylyltransferase

1

0

High-throughput

0.458

High

1346195

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

1379315

BCL9
Protein BCL9 homolog

1

0

High-throughput

0.458

High

1440050

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.458

High

1469770

MOC2B
Molybdopterin synthase catalytic subunit

1

0

High-throughput

0.458

High

1470762

VRET
Protein vreteno

1

0

High-throughput

0.458

High

1473384

CUP
Protein cup

1

0

High-throughput

0.458

High

1473399

Q9VWP5
Hat-trick, isoform D

1

0

High-throughput

0.458

High

1473410

Q9W1Q8
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.458

High

263005

TENM
Teneurin-m

1

4

High-throughput

0.445

High

1473419

4EBP
Eukaryotic translation initiation factor 4E-binding protein

1

1

High-throughput

0.445

High

53069

A1Z7K2
FI03455p

1

12

High-throughput

0.437

High

56378

ZASP
PDZ and LIM domain protein Zasp

1

10

High-throughput

0.437

High

69256

A8JUU3
Secretory 16, isoform D

1

8

High-throughput

0.437

High

119805

M9PBC6
Bub3 interacting GLEBS and zinc finger domain protein, isoform F

1

3

High-throughput

0.437

High

356411

O97102
Small ubiquitin-related modifier

1

6

High-throughput

0.437

High

427001

EF1A2
Elongation factor 1-alpha 2

1

8

High-throughput

0.437

High

809495

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

832262

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.437

High

856474

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.437

High

867907

TAF4
Transcription initiation factor TFIID subunit 4

1

1

High-throughput

0.437

High

870613

RL23
Large ribosomal subunit protein uL14

1

3

High-throughput

0.437

High

896163

MSL3
Protein male-specific lethal-3

1

1

High-throughput

0.437

High

898299

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.437

High

898344

RL22
Large ribosomal subunit protein eL22

1

3

High-throughput

0.437

High

1055729

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

1069307

Q0E8J0
MOG interacting and ectopic P-granules protein 1

1

1

High-throughput

0.437

High

1304051

SLE
Protein slender lobes

1

7

High-throughput

0.437

High

1375317

VDAC
Voltage-dependent anion-selective channel

1

2

High-throughput

0.437

High

1457985

NH2L1
NHP2-like protein 1 homolog

1

4

High-throughput

0.437

High

1465786

HCF
Host cell factor

1

15

High-throughput

0.437

High

1467870

S39AD
Zinc transporter ZIP13 homolog

1

3

High-throughput

0.437

High

1468035

Q9VAJ2
Mitotic checkpoint protein BUB3

1

13

High-throughput

0.437

High

1468832

RING1
E3 ubiquitin-protein ligase RING1

1

10

High-throughput

0.437

High

1473371

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.437

High

1473375

SLEL
Slender lobes-like protein

1

1

High-throughput

0.437

High

1473380

Q9VJD1
Glucosidase 2 subunit beta

1

2

High-throughput

0.437

High

1473391

Q9VS86
Peptidase S1 domain-containing protein

1

4

High-throughput

0.437

High

1473392

Q9VUB5
UpSET, isoform A

1

1

High-throughput

0.437

High

1473398

RS10B
Small ribosomal subunit protein eS10B

1

1

High-throughput

0.437

High

1473405

Q9VZB5
MIP31077p

1

1

High-throughput

0.437

High

1473406

Q9VZF2
LD05244p

1

5

High-throughput

0.437

High

1473407

Q9W0A8
FI01658p

1

1

High-throughput

0.437

High

1473411

NU214
Nuclear pore complex protein Nup214

1

4

High-throughput

0.437

High

1473412

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.437

High

1473417

Q9W3V2
FI19713p1

1

20

High-throughput

0.437

High

1473418

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.437

High

1473372

Q9VFH2
Hexamethylene bisacetamide inducible, isoform A

1

0

High-throughput

0.426

High

1175165

NETB
Netrin-B

1

2

High-throughput

0.407

High

57133

A1ZAU6
FI05912p

1

0

High-throughput

0.249

Low

145767

PSN
Presenilin homolog

1

0

High-throughput

0.249

Low

197839

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.249

Low

465898

CO4A1
Collagen alpha-1(IV) chain

1

0

High-throughput

0.249

Low

607501

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.249

Low

782970

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

831925

PEP
Zinc finger protein on ecdysone puffs

1

0

High-throughput

0.249

Low

891987

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.249

Low

938930

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

1013241

STIM
Stromal interaction molecule homolog

1

0

High-throughput

0.249

Low

1264819

Q7K180
LD02709p

1

0

High-throughput

0.249

Low

1267399

Q7KLX3
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

1343652

Q8SX89
Kugelkern, isoform A

1

0

High-throughput

0.249

Low

1344639

Q8SYU0
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.249

Low

1376902

CATL1
Cathepsin L1

1

0

High-throughput

0.249

Low

1464910

Q9V406
Activator protein 4

1

0

High-throughput

0.249

Low

1467286

Q9VA35
CIN85 and CD2AP related, isoform A

1

0

High-throughput

0.249

Low

1469716

Q9VBU9
40S ribosomal protein S27

1

0

High-throughput

0.249

Low

1473377

Q9VHH8
Beag

1

0

High-throughput

0.249

Low

1473379

Q9VHT6
Uncharacterized protein, isoform A

1

0

High-throughput

0.249

Low

1473382

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.249

Low

1473386

Q9VNA3
GH21273p

1

0

High-throughput

0.249

Low

1473404

Q9VZ00
FI19420p1

1

0

High-throughput

0.249

Low

1473408

Q9W1B9
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

1473413

SGF29
SAGA-associated factor 29kDa

1

0

High-throughput

0.249

Low

1473415

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.249

Low

1473397

FRIZ2
Frizzled-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025